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Literature DB >> 3258248

Influence of age on epidermal growth factor receptor level in the rat brain.

M Hiramatsu¹, M Kashimata, A Sato, M Murayama, N Minami.

Abstract

The influence of age on 125I-epidermal growth factor (EGF) binding to rat brain plasma membranes was investigated. The specific binding of EGF to membranes decreased gradually with age in both male and female rats. There was no significant difference in the specific binding between males and females. Scatchard analysis of the binding data showed that the decrease in EGF binding with age was due to a decrease in the number of EGF receptors.

Entities: Gene Species

Mesh：

Substances：

Year: 1988 PMID： 3258248 DOI： 10.1007/bf01960230

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

14 in total

1. Isolation and structure of urogastrone and its relationship to epidermal growth factor.

Authors: H Gregory
Journal: Nature Date: 1975-09-25 Impact factor: 49.962

2. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.

Authors: S COHEN
Journal: J Biol Chem Date: 1962-05 Impact factor: 5.157

3. Levels of epidermal growth factor in mice: tissues measured by a specific radioreceptor assay.

Authors: L Frati; G Cenci; G Sbaraglia; D V Teti; I Covelli
Journal: Life Sci Date: 1976-05-01 Impact factor: 5.037

4. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

Review 5. Epidermal growth factor: chemical and biological characterization.

Authors: S Cohen; J M Taylor
Journal: Recent Prog Horm Res Date: 1974

6. Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.

Authors: C R Savage; S Cohen
Journal: J Biol Chem Date: 1972-12-10 Impact factor: 5.157

Review 7. Development of the blood-brain barrier.

Authors: N R Saunders; K Møllgård
Journal: J Dev Physiol Date: 1984-02

8. Epidermal growth factor is not detectable in developing and adult rodent brain by a sensitive double-site enzyme immunoassay.

Authors: R Probstmeier; M Schachner
Journal: Neurosci Lett Date: 1986-01-30 Impact factor: 3.046

Influence of age on epidermal growth factor receptor level in the rat brain.

1. Isolation and structure of urogastrone and its relationship to epidermal growth factor.

2. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.

3. Levels of epidermal growth factor in mice: tissues measured by a specific radioreceptor assay.

4. Protein measurement with the Folin phenol reagent.

Review 5. Epidermal growth factor: chemical and biological characterization.

6. Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.

Review 7. Development of the blood-brain barrier.

8. Epidermal growth factor is not detectable in developing and adult rodent brain by a sensitive double-site enzyme immunoassay.

9. Epidermal growth factor does not cross the blood-brain barrier.

10. Thyroid-dependent maturation of neonatal brain but not lung epidermal growth factor receptors.

1. Neurotrophic factors in neurodegenerative disorders: model of Parkinson's disease.

Review 2. Neurotrophic factors for the investigation and treatment of movement disorders.

3. Central role of the EGF receptor in neurometabolic aging.

4. Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice.

Review 5. Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.