Alison Coombs1, Hannah Schilperoort2, Barbara Sargent3. 1. Children's Hospital Los Angeles, Division of Pediatric Rehabilitation Medicine, 4650 Sunset Blvd., Los Angeles, CA, 90027, United States; University of Southern California, Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, Los Angeles, CA, United States. Electronic address: acoombs@chla.usc.edu. 2. University of Southern California, Norris Medical Library, Los Angeles, CA, United States. 3. University of Southern California, Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, Los Angeles, CA, United States.
Abstract
BACKGROUND: Children with acute lymphoblastic leukemia (ALL) experience detrimental effects on motor function during and after chemotherapy. The objective of this systematic review was to evaluate the effect of exercise and motor interventions on physical activity and motor outcomes of children with ALL during and after chemotherapy. METHODS: Ten databases were searched. Nineteen studies were included: 11 randomized clinical trials (RCT), 2 controlled clinical trials (CCT), and 6 cohort studies. RESULTS: Participants included 508 children with ALL. Between-group results from RCTs and CCTs supported that exercise and motor intervention improved: fatigue during acute chemotherapy; physical activity, range of motion (ROM), strength, bone mineral density, aerobic capacity, and fatigue during maintenance chemotherapy; functional mobility, ROM, strength, and aerobic capacity during post-treatment survivorship; and participation, physical activity, ROM, strength, and coordination during multiple-phase interventions. CONCLUSION: Low quality evidence supports the efficacy of motor and exercise interventions for children and adolescents with ALL.
BACKGROUND:Children with acute lymphoblastic leukemia (ALL) experience detrimental effects on motor function during and after chemotherapy. The objective of this systematic review was to evaluate the effect of exercise and motor interventions on physical activity and motor outcomes of children with ALL during and after chemotherapy. METHODS: Ten databases were searched. Nineteen studies were included: 11 randomized clinical trials (RCT), 2 controlled clinical trials (CCT), and 6 cohort studies. RESULTS:Participants included 508 children with ALL. Between-group results from RCTs and CCTs supported that exercise and motor intervention improved: fatigue during acute chemotherapy; physical activity, range of motion (ROM), strength, bone mineral density, aerobic capacity, and fatigue during maintenance chemotherapy; functional mobility, ROM, strength, and aerobic capacity during post-treatment survivorship; and participation, physical activity, ROM, strength, and coordination during multiple-phase interventions. CONCLUSION: Low quality evidence supports the efficacy of motor and exercise interventions for children and adolescents with ALL.
Authors: Priscilla Vasquez; Johanna Escalante; Kimberly P Raghubar; Lisa S Kahalley; Olga A Taylor; Ida Ki Moore; Marilyn J Hockenberry; Michael E Scheurer; Austin L Brown Journal: Pediatr Blood Cancer Date: 2021-12-10 Impact factor: 3.167
Authors: Javier S Morales; Pedro L Valenzuela; Daniel Velázquez-Díaz; Adrián Castillo-García; David Jiménez-Pavón; Alejandro Lucia; Carmen Fiuza-Luces Journal: Cancers (Basel) Date: 2021-12-24 Impact factor: 6.639
Authors: Regine Söntgerath; Julia Däggelmann; Sabine V Kesting; Corina S Rueegg; Torge-Christian Wittke; Simon Reich; Katharina G Eckert; Sandra Stoessel; Carolina Chamorro-Viña; Joachim Wiskemann; Peter Wright; Anna Senn-Malashonak; Vanessa Oschwald; Anne-Marie Till; Miriam Götte Journal: Pediatr Res Date: 2021-04-15 Impact factor: 3.953
Authors: Winsome Lam; Doris Y P Leung; Su-Fang Li; Yan-Zhi Yi; Hai-Xia Wang; Li Zhou; Yan Yin; Stephen C W Chan; Kitty Y Y Chan; Jacqueline M C Ho; Frances K Y Wong Journal: Cancer Nurs Date: 2021-11-01 Impact factor: 2.760