Vladimir Han1,2,3, Matej Skorvanek1,2, Marenka Smit4, Monika Turcanova Koprusakova5,6, Tialda Hoekstra7, Jitse P van Dijk3,7, Marina A J Tijssen4, Zuzana Gdovinova1,2, Sijmen A Reijneveld7. 1. Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia. 2. Department of Neurology, University Hospital L. Pasteur, Kosice, Slovakia. 3. Graduate School Kosice Institute for Society and Health, Faculty of Medicine, Safarik University, Kosice, Slovakia. 4. Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. 5. Department of Neurology, University Hospital in Martin, Martin, Slovakia. 6. Department of Neurology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. 7. Department of Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract
OBJECTIVES: Non-motor symptoms (NMS) are commonly present along with motor impairment in patients with cervical dystonia (CD) and have a significant impact on health-related quality of life (HRQoL). However, the prevalence of NMS and their association with dystonia are still unclear. The aim of our study was to assess the prevalence of depression, anxiety, fatigue, apathy, pain, sleep problems, and excessive daytime sleepiness (EDS) in CD using different evaluation approaches and to explore their association with HRQoL relative to that of motor symptoms. MATERIALS AND METHODS: We enrolled 102 Slovak patients with CD. The severity of both motor and non-motor symptoms was assessed using validated scales. HRQoL was determined by the 36-item Short Form Health Survey (SF-36). Association of NMS with poor HRQoL was assessed using multiple regressions. RESULTS: The most frequent NMS in our sample were sleep impairment (67.3%), anxiety (65.5%), general and physical fatigue (57.5% and 52.9%, respectively), depression (47.1%), mental fatigue (31.4%), apathy (30.4%), reduced activity (29.4%), EDS (20.2%), and reduced motivation (18.6%). Univariate analysis showed that NMS, but not motor symptoms, were significantly linked to poor HRQoL, with EDS being most commonly associated with poor HRQoL, followed by disrupted sleep, depression, and fatigue. CONCLUSIONS: The prevalence of NMS among patients with CD is high, and some NMS are strongly associated with poor HRQoL, while motor impairment was not associated with the severity of NMS or poor HRQoL. Actively diagnosing and treating NMS should therefore be a routine part of the clinical management of patients with CD.
OBJECTIVES: Non-motor symptoms (NMS) are commonly present along with motor impairment in patients with cervical dystonia (CD) and have a significant impact on health-related quality of life (HRQoL). However, the prevalence of NMS and their association with dystonia are still unclear. The aim of our study was to assess the prevalence of depression, anxiety, fatigue, apathy, pain, sleep problems, and excessive daytime sleepiness (EDS) in CD using different evaluation approaches and to explore their association with HRQoL relative to that of motor symptoms. MATERIALS AND METHODS: We enrolled 102 Slovak patients with CD. The severity of both motor and non-motor symptoms was assessed using validated scales. HRQoL was determined by the 36-item Short Form Health Survey (SF-36). Association of NMS with poor HRQoL was assessed using multiple regressions. RESULTS: The most frequent NMS in our sample were sleep impairment (67.3%), anxiety (65.5%), general and physical fatigue (57.5% and 52.9%, respectively), depression (47.1%), mental fatigue (31.4%), apathy (30.4%), reduced activity (29.4%), EDS (20.2%), and reduced motivation (18.6%). Univariate analysis showed that NMS, but not motor symptoms, were significantly linked to poor HRQoL, with EDS being most commonly associated with poor HRQoL, followed by disrupted sleep, depression, and fatigue. CONCLUSIONS: The prevalence of NMS among patients with CD is high, and some NMS are strongly associated with poor HRQoL, while motor impairment was not associated with the severity of NMS or poor HRQoL. Actively diagnosing and treating NMS should therefore be a routine part of the clinical management of patients with CD.
Authors: Johanna Junker; Brian D Berman; James Hall; Deena W Wahba; Valerie Brandt; Joel S Perlmutter; Joseph Jankovic; Irene A Malaty; Aparna Wagle Shukla; Stephen G Reich; Alberto J Espay; Kevin R Duque; Neepa Patel; Emmanuel Roze; Marie Vidailhet; H A Jinnah; Norbert Brüggemann Journal: J Neurol Neurosurg Psychiatry Date: 2021-02-09 Impact factor: 13.654
Authors: Francisco Pereira da Silva-Júnior; Camila Oliveira Dos Santos Alves; Sônia Maria Cesar Azevedo Silva; Vanderci Borges; Henrique Ballalai Ferraz; Maria Sheila Guimarães Rocha; João Carlos Papaterra Limongi; Egberto Reis Barbosa; Patrícia de Carvalho Aguiar Journal: Neurol Sci Date: 2021-07-23 Impact factor: 3.307