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Literature DB >> 3257824

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

H Riedel¹, S Massoglia, J Schlessinger, A Ullrich.

Abstract

The cell surface receptor for the mitogenic peptide epidermal growth factor (EGF) is involved in control of normal cell growth and may play a role in the genesis of human neoplasia such as squamous carcinoma and glioblastoma. Soft-agar growth and focus-formation experiments with NIH 3T3 mouse fibroblasts transfected with an expression plasmid demonstrated the ligand-dependent transforming potential of the human EGF receptor without structural alterations. Activation of overexpressed normal receptor alone appears to be sufficient for transformation of NIH 3T3 cells in vitro.

Entities: Disease Species

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Year: 1988 PMID： 3257824 PMCID： PMC279794 DOI： 10.1073/pnas.85.5.1477

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

41 in total

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Authors: H C Birnboim; J Doly
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2. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

3. Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells.

Authors: G N Gill; C S Lazar
Journal: Nature Date: 1981-09-24 Impact factor: 49.962

4. The erbB gene of avian erythroblastosis virus is a member of the src gene family.

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Authors: D J Slamon; G M Clark; S G Wong; W J Levin; A Ullrich; W L McGuire
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7. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

Authors: J Downward; Y Yarden; E Mayes; G Scrace; N Totty; P Stockwell; A Ullrich; J Schlessinger; M D Waterfield
Journal: Nature Date: 1984 Feb 9-15 Impact factor: 49.962

8. Plasmid-directed synthesis of hepatitis B surface antigen in monkey cells.

Authors: C W Crowley; C C Liu; A D Levinson
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9. A monoclonal antibody to the human epidermal growth factor receptor.

Authors: M D Waterfield; E L Mayes; P Stroobant; P L Bennet; S Young; P N Goodfellow; G S Banting; B Ozanne
Journal: J Cell Biochem Date: 1982 Impact factor: 4.429

10. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.

Authors: G T Merlino; Y H Xu; S Ishii; A J Clark; K Semba; K Toyoshima; T Yamamoto; I Pastan
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2. Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.

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Authors: R J Pelley; N J Maihle; C Boerkoel; H K Shu; T H Carter; C Moscovici; H J Kung
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6. Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.

Authors: T J Velu; W C Vass; D R Lowy; L Beguinot
Journal: Mol Cell Biol Date: 1989-04 Impact factor: 4.272

7. Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells.

Authors: M J McManus; D C Connolly; N J Maihle
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9. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

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Journal: Mol Cell Biol Date: 1992-11 Impact factor: 4.272

10. A 34-kd protein with strong homology to ras-like proteins inhibits epidermal growth factor activity.

Authors: D S Strayer; J Mathew
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