Deniss Sõritsa1,2, Evelin Mäestu3, Margit Nuut4, Jarek Mäestu3, Jairo H Migueles5, Siret Läänelaid6,7, Aivar Ehrenberg4, Aire Sekavin4, Andrei Sõritsa2, Andres Salumets1,8,9, Francisco B Ortega5,10, Signe Altmäe11,12,13. 1. Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, 51014, Tartu, Estonia. 2. Elite Clinic, 50407, Tartu, Estonia. 3. Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, University of Tartu, 51014, Tartu, Estonia. 4. Tartu University Hospital's Women's Clinic, 51014, Tartu, Estonia. 5. PROFITH 'PROmoting FITness and Health through physical activity' Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, 18071, Granada, Spain. 6. Department of Family Medicine, Faculty of Medicine, University of Tartu, 50411, Tartu, Estonia. 7. Tartu Health Care College, 50411, Tartu, Estonia. 8. Competence Centre on Health Technologies, 50410, Tartu, Estonia. 9. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, FI-00029 HUS, Helsinki, Finland. 10. Department of Biosciences and Nutrition, NOVUM, Karolinska Institutet, 14183, Huddinge, Sweden. 11. Competence Centre on Health Technologies, 50410, Tartu, Estonia. signealtmae@ugr.es. 12. Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Avda. Fuente Nueva S/N, 18071, Granada, Spain. signealtmae@ugr.es. 13. Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. signealtmae@ugr.es.
Abstract
PURPOSE: To evaluate the association of objectively measured physical activity (PA) and sedentary behaviour before and during in vitro fertilization (IVF) with controlled ovarian stimulation (COS) and pregnancy outcomes. METHODS: This longitudinal study involved 107 infertile women undergoing IVF treatment. PA and sedentary behaviour were measured for 14 consecutive days using accelerometry as follows: (1) before IVF treatment, (2) during IVF at the implantation time, immediately after embryo transfer, and (3) after positive pregnancy test. Total screen time was assessed by questionnaires. COS results were measured as the number of oocytes and embryos obtained, and the study outcomes included positive hCG, clinical pregnancy, and live birth. RESULTS: Compared with baseline activity levels, women significantly reduced their PA and increased sedentary behaviour during IVF (p ≤ 0.001). Higher average PA, light PA, and ratio between breaks in every ≥ 30-min blocks of sedentary time showed positive associations, while sedentary time, number, and time accumulated in blocks of ≥ 30 min of sedentary time associated negatively with oocyte and embryo counts (all p < 0.05). Women with high total screen time during non-work days (≥ 7 h) obtained 4.7 oocytes (p = 0.005) and 2.8 embryos (p = 0.008) less in COS. PA and sedentary behaviour before and during IVF did not affect the positive hCG, clinical pregnancy, and live birth outcomes. CONCLUSION: Our study results suggest that higher time spent in PA and lower time spent in sedentary behaviour before entering assisted reproduction is associated with better COS outcomes, while activity levels before and during IVF do not affect the implantation, pregnancy, and live birth outcomes.
PURPOSE: To evaluate the association of objectively measured physical activity (PA) and sedentary behaviour before and during in vitro fertilization (IVF) with controlled ovarian stimulation (COS) and pregnancy outcomes. METHODS: This longitudinal study involved 107 infertile women undergoing IVF treatment. PA and sedentary behaviour were measured for 14 consecutive days using accelerometry as follows: (1) before IVF treatment, (2) during IVF at the implantation time, immediately after embryo transfer, and (3) after positive pregnancy test. Total screen time was assessed by questionnaires. COS results were measured as the number of oocytes and embryos obtained, and the study outcomes included positive hCG, clinical pregnancy, and live birth. RESULTS: Compared with baseline activity levels, women significantly reduced their PA and increased sedentary behaviour during IVF (p ≤ 0.001). Higher average PA, light PA, and ratio between breaks in every ≥ 30-min blocks of sedentary time showed positive associations, while sedentary time, number, and time accumulated in blocks of ≥ 30 min of sedentary time associated negatively with oocyte and embryo counts (all p < 0.05). Women with high total screen time during non-work days (≥ 7 h) obtained 4.7 oocytes (p = 0.005) and 2.8 embryos (p = 0.008) less in COS. PA and sedentary behaviour before and during IVF did not affect the positive hCG, clinical pregnancy, and live birth outcomes. CONCLUSION: Our study results suggest that higher time spent in PA and lower time spent in sedentary behaviour before entering assisted reproduction is associated with better COS outcomes, while activity levels before and during IVF do not affect the implantation, pregnancy, and live birth outcomes.
Authors: Kelly R Evenson; Kathryn C Calhoun; Amy H Herring; David Pritchard; Fang Wen; Anne Z Steiner Journal: Fertil Steril Date: 2014-02-10 Impact factor: 7.329
Authors: Siret Läänelaid; Francisco B Ortega; Theodora Kunovac Kallak; Lana Joelsson; Jonatan R Ruiz; Julius Hreinsson; Kjell Wånggren; Anneli Stavreus-Evers; Ruth Kalda; Andres Salumets; Signe Altmäe Journal: Int J Environ Res Public Health Date: 2021-03-08 Impact factor: 3.390