Shanshan Li1, Baibing Mi1, Pengfei Qu2, Danmeng Liu1, Fangliang Lei1, Duolao Wang3, Lingxia Zeng1, Yijun Kang1, Yuan Shen1, Leilei Pei1, Zhonghai Zhu1, Hong Yan1,4, Xin Liu5, Shaonong Dang6. 1. Department of Epidemiology and Health Statistics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China. 2. Translational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, People's Republic of China. 3. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. 4. Nutrition and Food Safety Engineering Research Center of Shaanxi Province, Xi'an, Shaanxi, 710061, People's Republic of China. 5. Department of Epidemiology and Health Statistics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China. xinliu@xjtu.edu.cn. 6. Department of Epidemiology and Health Statistics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China. tjdshn@xjtu.edu.cn.
Abstract
PURPOSE: Evidence about the effect of maternal vitamin B12 supplementation on offspring's vitaminB12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status. METHODS: In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B12, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates. RESULTS: Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitaminB12 (P = 0.001) and lower homocysteine concentrations (P = 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B12 concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (Pinteraction = 0.060). CONCLUSIONS:Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B12 status in rural northwest China.
RCT Entities:
PURPOSE: Evidence about the effect of maternal vitamin B12 supplementation on offspring's vitamin B12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status. METHODS: In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B12, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates. RESULTS: Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B12 (P = 0.001) and lower homocysteine concentrations (P = 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B12 concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (Pinteraction = 0.060). CONCLUSIONS: Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B12 status in rural northwest China.
Entities:
Keywords:
Antenatal vitamin B complex supplementation; Cluster randomized controlled trial; Newborns; Rural northwest china; Vitamin B12 status
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