Background: Coronavirus disease 2019 (COVID-19) has spread to almost every region and country in the world, leading to widespread travel restrictions and national lockdowns. Currently, there are limited epidemiological and clinical data on COVID-19 patients from low and middle-income countries. We conducted a retrospective single-center study of the first 100 individuals with suspected COVID-19 (between Jan. 25 and Mar. 29, 2020) admitted to San Lazaro Hospital (SLH), the national infectious diseases referral hospital in Manila, Philippines. Results: Demographic data, travel history, clinical features, and outcomes were summarized and compared between COVID-19 confirmed and non-confirmed cases. The first two confirmed cases were Chinese nationals, admitted on Jan. 25. The third confirmed case was a Filipino, admitted on Mar. 8. Trends toward confirmed COVID-19 cases not reporting international travel and being admitted to SLH from the densely populated area of Manila city were observed during Mar. 8-29. All 42 of the 100 confirmed COVID-19 cases were adults, 40% were aged 60 years and above and 55% were male. Three were health workers. Among individuals with suspected COVID-19, confirmed cases were more likely to be older, Filipino, not report international travel history and have at least one underlying disease, particularly diabetes, report difficulty in breathing, and a longer duration of symptoms. In over 90% of non-COVID-19 cases, the alternative diagnosis was respiratory. Nine (21%) confirmed cases died. The median duration from symptoms onset to death was 11.5 (range: 8-18) days. Conclusions: Imported COVID-19 cases have reduced but local transmission persists and there is a trend toward cases being admitted to SLH from densely populated areas. This study highlights the difficulty in diagnosing COVID-19 on clinical grounds and the importance of diagnostic capacity in all settings. Difficulty of breathing was the only symptom associated with COVID-19 infection and should alert clinicians to the possibility of COVID-19. Clinical characteristics of confirmed COVID-19 cases and a hospital case fatality rate of 21% are comparable with other settings.
Background: Coronavirus disease 2019 (COVID-19) has spread to almost every region and country in the world, leading to widespread travel restrictions and national lockdowns. Currently, there are limited epidemiological and clinical data on COVID-19patients from low and middle-income countries. We conducted a retrospective single-center study of the first 100 individuals with suspected COVID-19 (between Jan. 25 and Mar. 29, 2020) admitted to San Lazaro Hospital (SLH), the national infectious diseases referral hospital in Manila, Philippines. Results: Demographic data, travel history, clinical features, and outcomes were summarized and compared between COVID-19 confirmed and non-confirmed cases. The first two confirmed cases were Chinese nationals, admitted on Jan. 25. The third confirmed case was a Filipino, admitted on Mar. 8. Trends toward confirmed COVID-19 cases not reporting international travel and being admitted to SLH from the densely populated area of Manila city were observed during Mar. 8-29. All 42 of the 100 confirmed COVID-19 cases were adults, 40% were aged 60 years and above and 55% were male. Three were health workers. Among individuals with suspected COVID-19, confirmed cases were more likely to be older, Filipino, not report international travel history and have at least one underlying disease, particularly diabetes, report difficulty in breathing, and a longer duration of symptoms. In over 90% of non-COVID-19 cases, the alternative diagnosis was respiratory. Nine (21%) confirmed cases died. The median duration from symptoms onset to death was 11.5 (range: 8-18) days. Conclusions: Imported COVID-19 cases have reduced but local transmission persists and there is a trend toward cases being admitted to SLH from densely populated areas. This study highlights the difficulty in diagnosing COVID-19 on clinical grounds and the importance of diagnostic capacity in all settings. Difficulty of breathing was the only symptom associated with COVID-19infection and should alert clinicians to the possibility of COVID-19. Clinical characteristics of confirmed COVID-19 cases and a hospital case fatality rate of 21% are comparable with other settings.
Authors: Matt Arentz; Eric Yim; Lindy Klaff; Sharukh Lokhandwala; Francis X Riedo; Maria Chong; Melissa Lee Journal: JAMA Date: 2020-04-28 Impact factor: 56.272
Authors: Alberto Zangrillo; Luigi Beretta; Anna Mara Scandroglio; Giacomo Monti; Evgeny Fominskiy; Sergio Colombo; Federica Morselli; Alessandro Belletti; Paolo Silvani; Martina Crivellari; Fabrizio Monaco; Maria Luisa Azzolini; Raffaella Reineke; Pasquale Nardelli; Marianna Sartorelli; Carmine D Votta; Annalisa Ruggeri; Fabio Ciceri; Francesco De Cobelli; Moreno Tresoldi; Lorenzo Dagna; Patrizia Rovere-Querini; Ary Serpa Neto; Rinaldo Bellomo; Giovanni Landoni Journal: Crit Care Resusc Date: 2020-04-23 Impact factor: 2.159
Authors: Edna M Edrada; Edmundo B Lopez; Jose Benito Villarama; Eumelia P Salva Villarama; Bren F Dagoc; Chris Smith; Ana Ria Sayo; Jeffrey A Verona; Jamie Trifalgar-Arches; Jezreel Lazaro; Ellen Grace M Balinas; Elizabeth Freda O Telan; Lynsil Roy; Myvie Galon; Carl Hill N Florida; Tatsuya Ukawa; Annavi Marie G Villaneuva; Nobuo Saito; Jean Raphael Nepomuceno; Koya Ariyoshi; Celia Carlos; Amalea Dulcene Nicolasora; Rontgene M Solante Journal: Trop Med Health Date: 2020-04-14
Authors: Marta Colaneri; Paolo Sacchi; Valentina Zuccaro; Simona Biscarini; Michele Sachs; Silvia Roda; Teresa Chiara Pieri; Pietro Valsecchi; Antonio Piralla; Elena Seminari; Angela Di Matteo; Stefano Novati; Laura Maiocchi; Layla Pagnucco; Marcello Tirani; Fausto Baldanti; Francesco Mojoli; Stefano Perlini; Raffaele Bruno Journal: Euro Surveill Date: 2020-04