Zuanfang Li1,2,3, Minguang Yang3,4,5, Yunjiao Lin5,6, Shengxiang Liang3,4,5, Weilin Liu7, Bin Chen8, Sheng Huang4,5, Jianhong Li4,5, Jing Tao7, Lidian Chen7. 1. Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China. 2. Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fuzhou, China. 3. Rehabilitation Medical Technology Joint National Local Engineering Research Center, Fuzhou, China. 4. Fujian Collaborative Innovation Center for Rehabilitation Technology, Fuzhou, China. 5. TCM Rehabilitation Research Center of SATCM, Fuzhou, China. 6. Xiamen Humanity Rehabilitation Hospital, Xiamen, China. 7. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China. 8. Department of Rehabilitation, The Affiliated People's Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Abstract
BACKGROUND: To evaluate whether electroacupuncture (EA) treatment at LI11 and ST36 could reduce motor impairments and enhance brain functional recovery in a rat model of ischemic stroke. METHODS: A rat model of middle cerebral artery occlusion (MCAO) was established. EA at LI11 and ST36 was started at 24 h (MCAO + EA group) after ischemic stroke modeling. Untreated model (MCAO) and sham-operated (Sham) groups were included as controls. The neurological deficits of all groups were assessed using modified neurologic severity scores (mNSS) at 24 h and 14 days after MCAO. To further investigate the effect of EA on infarct volume and brain function, functional magnetic resonance imaging was used to estimate the size of the brain lesions and neural activities of each group at 14 days after ischemic stroke. RESULTS: EA treatment of MCAO rats led to a significant reduction in the infarct volumes accompanied by functional recovery, reflected in improved mNSS outcomes and motor functional performances. Furthermore, functional connectivity between the left motor cortex and left cerebellum posterior lobe, right motor cortex, left striatum and bilateral sensory cortex were decreased in MCAO group but increased after EA treatment. CONCLUSION: EA at LI11 and ST36 could enhance the functional connectivity between the left motor cortex and the motor function-related brain regions, including the motor cortex, sensory cortex and striatum, in rats. EA exhibits potential as a treatment for ischemic stroke.
BACKGROUND: To evaluate whether electroacupuncture (EA) treatment at LI11 and ST36 could reduce motor impairments and enhance brain functional recovery in a rat model of ischemic stroke. METHODS: A rat model of middle cerebral artery occlusion (MCAO) was established. EA at LI11 and ST36 was started at 24 h (MCAO + EA group) after ischemic stroke modeling. Untreated model (MCAO) and sham-operated (Sham) groups were included as controls. The neurological deficits of all groups were assessed using modified neurologic severity scores (mNSS) at 24 h and 14 days after MCAO. To further investigate the effect of EA on infarct volume and brain function, functional magnetic resonance imaging was used to estimate the size of the brain lesions and neural activities of each group at 14 days after ischemic stroke. RESULTS: EA treatment of MCAOrats led to a significant reduction in the infarct volumes accompanied by functional recovery, reflected in improved mNSS outcomes and motor functional performances. Furthermore, functional connectivity between the left motor cortex and left cerebellum posterior lobe, right motor cortex, left striatum and bilateral sensory cortex were decreased in MCAO group but increased after EA treatment. CONCLUSION: EA at LI11 and ST36 could enhance the functional connectivity between the left motor cortex and the motor function-related brain regions, including the motor cortex, sensory cortex and striatum, in rats. EA exhibits potential as a treatment for ischemic stroke.
Entities:
Keywords:
acupuncture; electroacupuncture; magnetic resonance imaging; neurology; stroke