Literature DB >> 32575608

EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis.

Anthony Genna1, Aline M Vanwynsberghe1, Amélie V Villard1, Charles Pottier1,2, Julien Ancel3,4, Myriam Polette4,5, Christine Gilles1.   

Abstract

Epithelial-mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology of circulating tumor cells (CTCs) and contribute to their heterogeneity. Here, we review major EMT-driven properties that may help hybrid Epithelial/Mesenchymal CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, further supporting the relevance of CTCs in personalized medicine.

Entities:  

Keywords:  CTC; EMT; coagulation; early metastasis; heterogeneity

Year:  2020        PMID： 32575608     DOI： 10.3390/cancers12061632

Source DB:  PubMed          Journal:  Cancers (Basel)        ISSN： 2072-6694            Impact factor:   6.639


  28 in total

1.  A data-assimilation approach to predict population dynamics during epithelial-mesenchymal transition.

Authors:  Mario J Mendez; Matthew J Hoffman; Elizabeth M Cherry; Christopher A Lemmon; Seth H Weinberg
Journal:  Biophys J       Date:  2022-07-14       Impact factor: 3.699

2.  Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer case.

Authors:  Shoujie Chai; Carmen Ruiz-Velasco; Amin Naghdloo; Milind Pore; Mohan Singh; Nicholas Matsumoto; Anand Kolatkar; Liya Xu; Stephanie Shishido; Ana Aparicio; Amado J Zurita; James Hicks; Peter Kuhn
Journal:  NPJ Precis Oncol       Date:  2022-06-21

3.  Regulation of Tissue Factor by CD44 Supports Coagulant Activity in Breast Tumor Cells.

Authors:  Amélie V Villard; Anthony Genna; Justine Lambert; Marianna Volpert; Agnès Noël; Brett Hollier; Myriam Polette; Aline M Vanwynsberghe; Christine Gilles
Journal:  Cancers (Basel)       Date:  2022-07-05       Impact factor: 6.575

4.  In Vivo Lymphatic Circulating Tumor Cells and Progression of Metastatic Disease.

Authors:  Mikyung Han; Julia Alex Watts; Azemat Jamshidi-Parsian; Urooba Nadeem; Mustafa Sarimollaoglu; Eric R Siegel; Vladimir P Zharov; Ekaterina I Galanzha
Journal:  Cancers (Basel)       Date:  2020-10-05       Impact factor: 6.575

Review 5.  Current Status and Future Perspectives of Liquid Biopsy in Small Cell Lung Cancer.

Authors:  Patricia Mondelo-Macía; Jorge García-González; Luis León-Mateos; Adrián Castillo-García; Rafael López-López; Laura Muinelo-Romay; Roberto Díaz-Peña
Journal:  Biomedicines       Date:  2021-01-07

Review 6.  Cancer Stem Cells-Key Players in Tumor Relapse.

Authors:  Monica Marzagalli; Fabrizio Fontana; Michela Raimondi; Patrizia Limonta
Journal:  Cancers (Basel)       Date:  2021-01-20       Impact factor: 6.639

7.  Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice.

Authors:  Janusz Blasiak; Ali Koskela; Elzbieta Pawlowska; Mikko Liukkonen; Johanna Ruuth; Elisa Toropainen; Juha M T Hyttinen; Johanna Viiri; John E Eriksson; Heping Xu; Mei Chen; Szabolcs Felszeghy; Kai Kaarniranta
Journal:  Int J Mol Sci       Date:  2021-02-08       Impact factor: 5.923

Review 8.  The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition.

Authors:  Fernán Gómez-Valenzuela; Enrico Escobar; Ricardo Pérez-Tomás; Viviana P Montecinos
Journal:  Front Oncol       Date:  2021-06-10       Impact factor: 6.244

Review 9.  Emerging Concepts of Hybrid Epithelial-to-Mesenchymal Transition in Cancer Progression.

Authors:  Dona Sinha; Priyanka Saha; Anurima Samanta; Anupam Bishayee
Journal:  Biomolecules       Date:  2020-11-16

Review 10.  Multifaceted Roles of DNA Methylation in Neoplastic Transformation, from Tumor Suppressors to EMT and Metastasis.

Authors:  Laura Casalino; Pasquale Verde
Journal:  Genes (Basel)       Date:  2020-08-12       Impact factor: 4.096
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