| Literature DB >> 3257519 |
D Giulian1, D G Young, J Woodward, D C Brown, L B Lachman.
Abstract
The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.Entities:
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Year: 1988 PMID： 3257519 PMCID： PMC6569312
Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167