| Literature DB >> 3257399 |
P J Maddison1, D A Isenberg, N J Goulding, J Leddy, R P Skinner.
Abstract
The relevance of antibodies for La(SSB) as a marker of a distinctive systemic lupus erythematosus (SLE) subset was studied in 185 lupus patients. Anti La was detected in 39 (21%) and was accompanied invariably by anti Ro. Clinically, anti La-positive patients were distinguished by a later age of disease onset, and a low frequency of lupus nephritis. In common with other anti Ro-positive patients they showed a high frequency of keratoconjunctivitis sicca. Anti La identified patients with higher titres of anti Ro antibodies and was significantly associated with HLA-DR3. Serological markers such as these are useful for identifying more homogeneous populations of SLE patients for studies of aetiology and pathogenesis.Entities:
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Year: 1988 PMID： 3257399 DOI： 10.1093/rheumatology/27.1.27
Source DB: PubMed Journal: Br J Rheumatol ISSN： 0263-7103