| Literature DB >> 32572265 |
Farshad Nassiri1,2, Ankur Chakravarthy3, Shengrui Feng3,4, Shu Yi Shen3, Romina Nejad1, Jeffrey A Zuccato1,2, Mathew R Voisin1,2, Vikas Patil1, Craig Horbinski5,6, Kenneth Aldape1,7, Gelareh Zadeh8,9, Daniel D De Carvalho10,11.
Abstract
Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate common primary intracranial tumors that share cell-of-origin lineages and can be challenging to distinguish using standard-of-care imaging.Entities:
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Year: 2020 PMID： 32572265 PMCID： PMC8500275 DOI： 10.1038/s41591-020-0932-2
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440