Literature DB >> 32571818

Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada.

Nidhi R Parmar1,2, Reema Singh1,2, Irene Martin3, Sumudu R Perera1,2, Walter Demczuk3, Anthony Kusalik4, Jessica Minion5, Jo-Anne R Dillon6,2.   

Abstract

Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of Neisseria gonorrhoeae Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogenomic analysis revealed three distinctive clades and putative gonococcal transmission linkages involving a tetracycline-resistant N. gonorrhoeae outbreak and the clonal spread of susceptible isolates in men.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Neisseria gonorrhoeae; antimicrobial resistance prediction; single-nucleotide polymorphisms; strain types; transmission linkages; whole-genome sequencing

Mesh：

Substances：

Year:  2020        PMID： 32571818      PMCID： PMC7449210          DOI： 10.1128/AAC.02514-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  38 in total

1.  Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae.

Authors:  Sho Takahata; Nami Senju; Yumi Osaki; Takuji Yoshida; Takashi Ida
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

Review 2.  Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

3.  Genetic characterisation of Neisseria gonorrhoeae resistant to both ceftriaxone and azithromycin.

Authors:  David M Whiley; Amy Jennison; Julie Pearson; Monica M Lahra
Journal:  Lancet Infect Dis       Date:  2018-07       Impact factor: 25.071

4.  Evaluation of the ResistancePlus GC (beta) assay: a commercial diagnostic test for the direct detection of ciprofloxacin susceptibility or resistance in Neisseria gonorrhoeae.

Authors:  Samantha Ebeyan; Madeline Windsor; Amanda Bordin; Lebogang Mhango; Simon Erskine; Ella Trembizki; Elisa Mokany; Lit Yeen Tan; David Whiley
Journal:  J Antimicrob Chemother       Date:  2019-07-01       Impact factor: 5.790

5.  High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants.

Authors:  Mei Hu; Sobhan Nandi; Christopher Davies; Robert A Nicholas
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

6.  High prevalence of Neisseria gonorrhoeae with high-level resistance to azithromycin in Hangzhou, China.

Authors:  Chunshan Ni; Juan Xue; Chuanling Zhang; Haiyong Zhou; Stijn van der Veen
Journal:  J Antimicrob Chemother       Date:  2016-04-18       Impact factor: 5.790

7.  Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance, a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains.

Authors:  W Demczuk; S Sidhu; M Unemo; D M Whiley; V G Allen; J R Dillon; M Cole; C Seah; E Trembizki; D L Trees; E N Kersh; A J Abrams; H J C de Vries; A P van Dam; I Medina; A Bharat; M R Mulvey; G Van Domselaar; I Martin
Journal:  J Clin Microbiol       Date:  2017-02-22       Impact factor: 5.948

8.  Non-culture Neisseria gonorrhoeae molecular penicillinase production surveillance demonstrates the long-term success of empirical dual therapy and informs gonorrhoea management guidelines in a highly endemic setting.

Authors:  David J Speers; Rachel E Fisk; Namraj Goire; Donna B Mak
Journal:  J Antimicrob Chemother       Date:  2013-12-29       Impact factor: 5.790

9.  Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.

Authors:  Ivica Letunic; Peer Bork
Journal:  Nucleic Acids Res       Date:  2016-04-19       Impact factor: 16.971

10.  Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action.

Authors:  Teodora Wi; Monica M Lahra; Francis Ndowa; Manju Bala; Jo-Anne R Dillon; Pilar Ramon-Pardo; Sergey R Eremin; Gail Bolan; Magnus Unemo
Journal:  PLoS Med       Date:  2017-07-07       Impact factor: 11.069
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  1 in total

Review 1.  Bioinformatics tools used for whole-genome sequencing analysis of Neisseria gonorrhoeae: a literature review.

Authors:  Reema Singh; Anthony Kusalik; Jo-Anne R Dillon
Journal:  Brief Funct Genomics       Date:  2022-04-11       Impact factor: 4.840
  1 in total

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