Mojtaba Abrishami1, Fariba Tohidinezhad2, Ramin Daneshvar1, Arash Omidtabrizi1, Mahnaz Amini3,4, Alireza Sedaghat3, Shahram Amini4, Hamidreza Reihani5, Abolghasem Allahyari6, Mohsen Seddigh-Shamsi6, Mohammad Tayyebi7, Hamidreza Naderi8, Amin Bojdy8, Rozita Khodashahi8, Saeid Eslami2,9,10. 1. Eye Research Center, Mashhad University of Medical Sciences , Mashhad, Iran. 2. Department of Medical Informatics, Mashhad University of Medical Sciences , Mashhad, Iran. 3. Lung Diseases Research Center, Mashhad University of Medical Sciences , Mashhad, Iran. 4. Division of Sleep Medicine, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences , Mashhad, Iran. 5. Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran. 6. Department of Hematology Oncology, Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran. 7. Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran. 8. Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran. 9. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences , Mashhad, Iran. 10. Department of Medical Informatics, Amsterdam UMC, University of Amsterdam , Amsterdam, The Netherlands.
Abstract
PURPOSE: To evaluate ocular findings in patients with Coronavirus Disease 2019 (COVID-19) in the Northeast of Iran. METHODS: In a cross-sectional, observational study all consecutive patients with confirmed COVID-19 diagnosis at the central referral center of these patients in northeast of Iran were included. Ocular examinations (external and slit) were randomly performed for the patients who were admitted to the Intensive Care Unit (ICU) and six COVID wards of the hospital. Moreover, Chart records and serum chemistry results were collected. RESULTS: A total of 142 patients with the mean age of 62.6 ± 15 years (range: 23-96 years) and almost equal gender distribution (male: N = 77, 54.2%) were included in the study. During the initial external examination by the ophthalmologist, 44 (31%) patients were found to have conjunctival hyperemia and 22 (15.5%) patients had chemosis. Consecutive slit examination showed 41 (28.9%) conjunctival hyperemia, 22 (15.5%) chemosis, 11 (7.7%) cataract, and 9 (6.3%) diabetic retinopathy. The patients with at least one ocular manifestation had significantly higher blood urea levels at the time of admission compared to those with no obvious ocular involvement (median: 41.5, IQR: 28-66.3 vs. median: 33, IQR: 23.8-51.8, P = .023). Moreover, a significant difference was observed in the total white blood cell count, lymphocyte percent, neutrophil count, Erythrocyte Sedimentation Rate (ESR), and blood urea level between patients with positive and negative Polymerase Chain Reaction (PCR) for SARS-CoV-2 virus. None of the patients reported ocular symptoms prior to systemic involvement. The proportion of patients with at least one ocular manifestation was significantly higher in those admitted in the ICU compared to the non-ICU wards. wards. While conjunctival hyperemia was the most prevalent ocular finding in all patients, chemosis was the most common ocular manifestation in ICU admitted patients. CONCLUSION: Ocular manifestation was observed in more than half of our COVID-19 patients. Hence, it seems important to involve ophthalmologist in the diagnosis and management of these patients.
PURPOSE: To evaluate ocular findings in patients with Coronavirus Disease 2019 (COVID-19) in the Northeast of Iran. METHODS: In a cross-sectional, observational study all consecutive patients with confirmed COVID-19 diagnosis at the central referral center of these patients in northeast of Iran were included. Ocular examinations (external and slit) were randomly performed for the patients who were admitted to the Intensive Care Unit (ICU) and six COVID wards of the hospital. Moreover, Chart records and serum chemistry results were collected. RESULTS: A total of 142 patients with the mean age of 62.6 ± 15 years (range: 23-96 years) and almost equal gender distribution (male: N = 77, 54.2%) were included in the study. During the initial external examination by the ophthalmologist, 44 (31%) patients were found to have conjunctival hyperemia and 22 (15.5%) patients had chemosis. Consecutive slit examination showed 41 (28.9%) conjunctival hyperemia, 22 (15.5%) chemosis, 11 (7.7%) cataract, and 9 (6.3%) diabetic retinopathy. The patients with at least one ocular manifestation had significantly higher blood urea levels at the time of admission compared to those with no obvious ocular involvement (median: 41.5, IQR: 28-66.3 vs. median: 33, IQR: 23.8-51.8, P = .023). Moreover, a significant difference was observed in the total white blood cell count, lymphocyte percent, neutrophil count, Erythrocyte Sedimentation Rate (ESR), and blood urea level between patients with positive and negative Polymerase Chain Reaction (PCR) for SARS-CoV-2 virus. None of the patients reported ocular symptoms prior to systemic involvement. The proportion of patients with at least one ocular manifestation was significantly higher in those admitted in the ICU compared to the non-ICU wards. wards. While conjunctival hyperemia was the most prevalent ocular finding in all patients, chemosis was the most common ocular manifestation in ICU admitted patients. CONCLUSION: Ocular manifestation was observed in more than half of our COVID-19patients. Hence, it seems important to involve ophthalmologist in the diagnosis and management of these patients.
Authors: Reema Bansal; Ashish Markan; Nitin Gautam; Rashmi Ranjan Guru; P V M Lakshmi; Deeksha Katoch; Aniruddha Agarwal; Mini P Singh; Vikas Suri; Ritin Mohindra; Neeru Sahni; Ashish Bhalla; Pankaj Malhotra; Vishali Gupta; G D Puri Journal: Front Med (Lausanne) Date: 2021-06-24
Authors: Alexander C Rokohl; Niklas Loreck; Philomena A Wawer Matos; Sarah Zwingelberg; Max Augustin; Felix Dewald; Rafael S Grajewski; Florian Klein; Clara Lehmann; Ludwig M Heindl Journal: Clin Microbiol Infect Date: 2020-08-21 Impact factor: 13.310