Naoko Iwamoto1, Tomoyuki Aruga1, Hidekazu Asami2, Shin-Ichiro Horiguchi2. 1. Department of Breast Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan. 2. Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
Abstract
PURPOSE: The purpose of this study was to clarify the clinicopathological features of patients with false-negative FNAC and to determine the factors associatedwith negative fine-needle aspiration cytology (FNAC). METHODS: Patients with negative FNAC from January 2010 to December 2019 were included. The patients with positive sentinel nodes (SN) were divided into two groups: micrometastasis (≤ 2 mm) group, and macrometastasis (>2mm) group. The clinicopathological characteristics were compared between the two groups using the chi-squared test. RESULTS: A total of 165 patients with negative FNAC were included; 52 (31.5%) had positive SNs. Of the 52 patients, 13 (25%) had micrometastasis and the remaining 39 (75%) had macrometastasis. Of the 113 patients with negative SNs, none had found metastases in non-SNs. No significant differences were observed in age, cT stage, and subtype,and preoperativeultrasound findings between the two groups. CONCLUSIONS: The false-negative rate of FNAC was high (31.5%). Micrometastatic disease was seen in patients with negative FNAC, and this might be the cause of false-negative FNAC results. This article is protected by copyright. All rights reserved.
PURPOSE: The purpose of this study was to clarify the clinicopathological features of patients with false-negative FNAC and to determine the factors associatedwith negative fine-needle aspiration cytology (FNAC). METHODS:Patients with negative FNAC from January 2010 to December 2019 were included. The patients with positive sentinel nodes (SN) were divided into two groups: micrometastasis (≤ 2 mm) group, and macrometastasis (>2mm) group. The clinicopathological characteristics were compared between the two groups using the chi-squared test. RESULTS: A total of 165 patients with negative FNAC were included; 52 (31.5%) had positive SNs. Of the 52 patients, 13 (25%) had micrometastasis and the remaining 39 (75%) had macrometastasis. Of the 113 patients with negative SNs, none had found metastases in non-SNs. No significant differences were observed in age, cT stage, and subtype,and preoperativeultrasound findings between the two groups. CONCLUSIONS: The false-negative rate of FNAC was high (31.5%). Micrometastatic disease was seen in patients with negative FNAC, and this might be the cause of false-negative FNAC results. This article is protected by copyright. All rights reserved.
Authors: Anna Weiss; Claire King; Julie Vincuilla; Tonia Parker; Leah Portnow; Faina Nakhlis; Laura Dominici; Elizabeth A Mittendorf; Tari A King Journal: Breast Cancer Res Treat Date: 2022-07-28 Impact factor: 4.624