Lei Wang1,1, Yehui Zhou1,1, Suhua Xia2, Linlin Lu1, Tiantian Dai1, Aoshuang Li1, Yan Chen1, Erli Gao1. 1. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. 2. Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Abstract
BACKGROUND: The new systemic inflammation response index (SIRI) constructed based on neutrophil, monocyte and lymphocyte counts in peripheral blood is considered to be related to the prognosis of a variety of tumours. OBJECTIVE: To evaluate the prognostic value of the SIRI in operable breast cancer patients and establish a nomogram to predict the survival of breast cancer patients. METHODS: A total of 949 patients with operable breast cancer were enrolled in the present study. RESULTS: The overall survival (OS) of breast cancer patients with SIRI ⩽ 0.65 was significantly higher than that of breast cancer patients with SIRI > 0.65 (P< 0.001). A nomogram generated based on SIRI, grade and TNM stage and SIRI predicted the 5- and 10-year survival rates of breast cancer patients more accurately than TNM stage alone. In addition, the change in SIRI relative to baseline at 4 weeks after surgery was closely related to the survival of breast cancer patients. Compared with those with no SIRI changes (absolute value of variation < 25%), breast cancer patients with an increase in SIRI > 75% or 25-75% had worse OS (P< 0.001). CONCLUSIONS: The SIRI before and after surgery is closely related to the prognosis of breast cancer patients.
BACKGROUND: The new systemic inflammation response index (SIRI) constructed based on neutrophil, monocyte and lymphocyte counts in peripheral blood is considered to be related to the prognosis of a variety of tumours. OBJECTIVE: To evaluate the prognostic value of the SIRI in operable breast cancerpatients and establish a nomogram to predict the survival of breast cancerpatients. METHODS: A total of 949 patients with operable breast cancer were enrolled in the present study. RESULTS: The overall survival (OS) of breast cancerpatients with SIRI ⩽ 0.65 was significantly higher than that of breast cancerpatients with SIRI > 0.65 (P< 0.001). A nomogram generated based on SIRI, grade and TNM stage and SIRI predicted the 5- and 10-year survival rates of breast cancerpatients more accurately than TNM stage alone. In addition, the change in SIRI relative to baseline at 4 weeks after surgery was closely related to the survival of breast cancerpatients. Compared with those with no SIRI changes (absolute value of variation < 25%), breast cancerpatients with an increase in SIRI > 75% or 25-75% had worse OS (P< 0.001). CONCLUSIONS: The SIRI before and after surgery is closely related to the prognosis of breast cancerpatients.
Authors: Tomasz Urbanowicz; Michał Michalak; Anna Olasińska-Wiśniewska; Michał Rodzki; Anna Witkowska; Aleksandra Gąsecka; Piotr Buczkowski; Bartłomiej Perek; Marek Jemielity Journal: Cells Date: 2022-03-26 Impact factor: 6.600