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Literature DB >> 3256814

Portal hypertension secondary to azathioprine in myasthenia gravis.

Abstract

A 52 year old man with myasthenia gravis and normal liver function was treated with neostigmine, prednisolone and azathioprine. Three years after starting azathioprine he developed clinical evidence of portal hypertension. A liver biopsy showed nodular regenerative hyperplasia (NRH). The development of NRH following azathioprine treatment in a patient with myasthenia gravis strengthens the case for a causal role of azathioprine in producing NRH and portal hypertension.

Entities: Chemical Disease Species

Mesh：

Substances：
Azathioprine

Year: 1988 PMID： 3256814 PMCID： PMC2429092 DOI： 10.1136/pgmj.64.758.950

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

6 in total

1. Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine.

Authors: A T Marubbio; B Danielson
Journal: Gastroenterology Date: 1975-09 Impact factor: 22.682

2. Idiopathic portal hypertension (perisinusoidal fibrosis) after renal transplantation.

Authors: C Nataf; G Feldmann; D Lebrec; C Degott; J M Descamps; B Rueff; J P Benhamou
Journal: Gut Date: 1979-06 Impact factor: 23.059

3. Azathioprine hypersensitivity manifesting as acute focal hepatocellular necrosis.

Authors: C Cooper; D W Cotton; N Minihane; M I Cawley
Journal: J R Soc Med Date: 1986-03 Impact factor: 5.344

4. Nodular transformation (nodular "regenerative" hyperplasia) of the liver. A clinicopathologic study of 30 cases.

Authors: F W Stromeyer; K G Ishak
Journal: Hum Pathol Date: 1981-01 Impact factor: 3.466

5. Intrahepatic cholestasis due to azathioprine.

Authors: M Sparberg; N Simon; F del Greco
Journal: Gastroenterology Date: 1969-10 Impact factor: 22.682

6. Nodular regenerative hyperplasia with portal hypertension in a patient with myasthenia gravis.

Authors: R Eliakim; M Ligumsky; O Jurim; D Shouval
Journal: Am J Gastroenterol Date: 1987-07 Impact factor: 10.864

6 in total

5 in total

5. Structural integrity and identification of causes of liver allograft dysfunction occurring more than 5 years after transplantation.

Authors: O Pappo; H Ramos; T E Starzl; J J Fung; A J Demetris
Journal: Am J Surg Pathol Date: 1995-02 Impact factor: 6.394

5 in total

Portal hypertension secondary to azathioprine in myasthenia gravis.

1. Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine.

2. Idiopathic portal hypertension (perisinusoidal fibrosis) after renal transplantation.

3. Azathioprine hypersensitivity manifesting as acute focal hepatocellular necrosis.

4. Nodular transformation (nodular "regenerative" hyperplasia) of the liver. A clinicopathologic study of 30 cases.

5. Intrahepatic cholestasis due to azathioprine.

6. Nodular regenerative hyperplasia with portal hypertension in a patient with myasthenia gravis.

Review 1. Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension.

2. Azathioprine and 6-Mercaptopurine-induced Liver Injury: Clinical Features and Outcomes.

3. Long term treatment of myasthenia gravis with azathioprine.

Review 4. Azathioprine-induced hepatitis and cholestasis occurring 1 year after treatment.

5. Structural integrity and identification of causes of liver allograft dysfunction occurring more than 5 years after transplantation.