Chengping Hu1, Ling Wang1, Yi Guo2, Zhicheng Cao2, Ying Lu2, Hongyun Qin2. 1. Administrative Office, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China. 2. Department of Psychiatric Control and Prevention, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.
Abstract
OBJECTIVE: To evaluate the risk factors for progress of mild cognitive impairment to dementia. METHODS: This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and MCI outcomes were evaluated using single-and multifactor ordered logistic regression analysis models. RESULTS: Of the 441 MCI, 77 progressed to dementia (MCIp: 17.5%, 95% CI: 14.4%-21.6%), 356 remained stable (MCIs: 80.7%, 95% CI: 77.0%-88.4%), and 8 reverted to normal cognition (MCIr: 1.8%, 95% CI: 0.6%-3.0%) at follow-up in 2017. Univariate ordinal regression analysis showed that diabetes (P = .052), marriage (P = .028), worker (P = .069), and manager (P = .075) may be the risk factor for the status of MCI. Multiple ordinal regression results showed that diabetes (P = .049) and marriage (P = .04) significantly affected the cognitive function changes in the MCI patients. CONCLUSION: Nondiabetics and being married may prevent the progression from MCI to dementia.
OBJECTIVE: To evaluate the risk factors for progress of mild cognitive impairment to dementia. METHODS: This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and MCI outcomes were evaluated using single-and multifactor ordered logistic regression analysis models. RESULTS: Of the 441 MCI, 77 progressed to dementia (MCIp: 17.5%, 95% CI: 14.4%-21.6%), 356 remained stable (MCIs: 80.7%, 95% CI: 77.0%-88.4%), and 8 reverted to normal cognition (MCIr: 1.8%, 95% CI: 0.6%-3.0%) at follow-up in 2017. Univariate ordinal regression analysis showed that diabetes (P = .052), marriage (P = .028), worker (P = .069), and manager (P = .075) may be the risk factor for the status of MCI. Multiple ordinal regression results showed that diabetes (P = .049) and marriage (P = .04) significantly affected the cognitive function changes in the MCI patients. CONCLUSION: Nondiabetics and being married may prevent the progression from MCI to dementia.