Beate Peter1,2, Nancy Potter3, Jennifer Davis1, Inbal Donenfeld-Peled1, Lizbeth Finestack4, Carol Stoel-Gammon5, Kari Lien1, Laurel Bruce1, Caitlin Vose6, Linda Eng1, Hanako Yokoyama1, Daniel Olds3, Mark VanDam3. 1. Speech and Hearing Science, College of Health Solutions, Arizona State University, Tempe, AZ, USA. 2. Department of Communication Sciences and Disorders, Saint Louis University, Saint Louis, MO, USA. 3. Department of Speech and Hearing Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA. 4. Department of Speech-Language-Hearing Services, University of Minnesota, Minneapolis, MN, USA. 5. Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA. 6. Department of Communication Sciences and Disorders, Syracuse University, Syracuse, NY, USA.
Abstract
Background: Speech and language therapy is typically initiated reactively after a child shows delays. Infants with classic galactosemia (CG), a metabolic disease with a known high risk for both speech and language disorders, hold the keys towards evaluating whether preventive treatment is effective when the risks are known at birth. We present pilot data from a randomized parallel trial of an innovative proactive speech and language intervention program, the Babble Boot Camp (BBC). Method: Five children with CG, otherwise healthy, participated in the study from approximately 2 to 24 months of age. One of these was randomly selected as control receiving conventional management, which typically starts at age 2-3 years. A pediatric speech-language pathologist met weekly via telepractice with the parents in the treatment cohort. Parents implemented the prespeech, speech, and language stimulation and expansion activities according to the intervention protocol. The control child was still too young for conventional treatment. Primary outcome measures were speech sound production complexity in babble and speech and expressive vocabulary size. Secondary outcome measures were vocalization rates and developmental milestones in communication, motor, and cognition. The trial is ongoing. Results: All four treated children had higher speech sound skills in babble, three had higher speech sound skills in meaningful speech, two had higher expressive vocabularies, three had higher global developmental scores, and two had higher vocalization rates, compared to the control child with CG. Discussion: Given the high risk for speech and language delays in children with CG, finding on-schedule abilities in two or more of the treated children but not the untreated child is unexpected under random conditions. The trends toward beneficial effects of the BBC on speech sound production, expressive language, and communication milestones warrant appropriately powered larger clinical trials with full randomization. Trial registration: ClinicalTrials.gov NCT03838016 (12 th February 2019). Copyright:
RCT Entities:
Background: Speech and language therapy is typically initiated reactively after a child shows delays. Infants with classic galactosemia (CG), a metabolic disease with a known high risk for both speech and language disorders, hold the keys towards evaluating whether preventive treatment is effective when the risks are known at birth. We present pilot data from a randomized parallel trial of an innovative proactive speech and language intervention program, the Babble Boot Camp (BBC). Method: Five children with CG, otherwise healthy, participated in the study from approximately 2 to 24 months of age. One of these was randomly selected as control receiving conventional management, which typically starts at age 2-3 years. A pediatric speech-language pathologist met weekly via telepractice with the parents in the treatment cohort. Parents implemented the prespeech, speech, and language stimulation and expansion activities according to the intervention protocol. The control child was still too young for conventional treatment. Primary outcome measures were speech sound production complexity in babble and speech and expressive vocabulary size. Secondary outcome measures were vocalization rates and developmental milestones in communication, motor, and cognition. The trial is ongoing. Results: All four treated children had higher speech sound skills in babble, three had higher speech sound skills in meaningful speech, two had higher expressive vocabularies, three had higher global developmental scores, and two had higher vocalization rates, compared to the control child with CG. Discussion: Given the high risk for speech and language delays in children with CG, finding on-schedule abilities in two or more of the treated children but not the untreated child is unexpected under random conditions. The trends toward beneficial effects of the BBC on speech sound production, expressive language, and communication milestones warrant appropriately powered larger clinical trials with full randomization. Trial registration: ClinicalTrials.gov NCT03838016 (12 th February 2019). Copyright:
Authors: Tammy C Hoffmann; Paul P Glasziou; Isabelle Boutron; Ruairidh Milne; Rafael Perera; David Moher; Douglas G Altman; Virginia Barbour; Helen Macdonald; Marie Johnston; Sarah E Lamb; Mary Dixon-Woods; Peter McCulloch; Jeremy C Wyatt; An-Wen Chan; Susan Michie Journal: BMJ Date: 2014-03-07
Authors: Beate Peter; Jennifer Davis; Lizbeth Finestack; Carol Stoel-Gammon; Mark VanDam; Laurel Bruce; Yookyung Kim; Linda Eng; Sarah Cotter; Emily Landis; Sam Beames; Nancy Scherer; Ina Knerr; Delaney Williams; Claire Schrock; Nancy Potter Journal: HGG Adv Date: 2022-05-20
Authors: Cynthia C Morton; Mary L Marazita; Beate Peter; Mabel L Rice; Shelly Jo Kraft; Julie Barkmeier-Kraemer; Carey Balaban; Michael Phillips; Jennifer Schoden; Deborah Maiese; Tabitha Hendershot; Carol M Hamilton Journal: Ann Hum Genet Date: 2021-09-28 Impact factor: 2.180
Authors: Beate Peter; Jennifer Davis; Sarah Cotter; Alicia Belter; Emma Williams; Melissa Stumpf; Laurel Bruce; Linda Eng; Yookyung Kim; Lizbeth Finestack; Carol Stoel-Gammon; Delaney Williams; Nancy Scherer; Mark VanDam; Nancy Potter Journal: Am J Speech Lang Pathol Date: 2021-10-19 Impact factor: 4.018