Antonio León-Jiménez1, Antonio Hidalgo-Molina2, Miguel Ángel Conde-Sánchez3, Aránzazu Pérez-Alonso4, José María Morales-Morales5, Eva María García-Gámez3, Juan Antonio Córdoba-Doña6. 1. Pulmonology, Allergy and Thoracic Surgery Department, Puerta del Mar University Hospital, Biomedical Research and Innovation Institute of Cádiz, Cádiz, Spain. Electronic address: antonio.leon.sspa@juntadeandalucia.es. 2. Pulmonology, Allergy and Thoracic Surgery Department, Puerta del Mar University Hospital, Biomedical Research and Innovation Institute of Cádiz, Cádiz, Spain. 3. Radiology Department, Puerto Real University Hospital, Puerto Real, Cádiz, Spain. 4. Occupational and Public Health and Preventive Medicine Service, Cádiz, Spain. 5. Pulmonology Unit, Puerto Real University Hospital, Puerto Real, Cádiz, Spain. 6. Public Health Service, Regional Directorate of the Department of Health and Families of Andalusia in Cádiz, Cádiz, Spain.
Abstract
BACKGROUND: Silicosis is rapidly emerging in high-income countries in relation to the replacement of natural stone with artificial stone, especially in the manufacturing and installation of kitchen and bathroom countertops. Progression of this form of silicosis following the cessation of exposure is unknown. RESEARCH QUESTION: The objective of this study was to determine the radiologic progression and lung function in individuals with artificial stone silicosis. STUDY DESIGN AND METHODS: Between 2009 and 2018, a total of 106 patients were diagnosed with artificial stone silicosis in the Bay of Cádiz area (southern Spain), 14.15% by using biopsy results and the remainder according to chest radiography and high-resolution CT imaging. Follow-up consisted of respiratory function tests and radiographic studies. All patients stopped working in the stone industry following diagnosis. RESULTS: All patients were men; their mean ± SD age at diagnosis was 36.2 ± 7.0 years, and the mean duration of exposure was 12.0 ± 4.3 years. At diagnosis, 99 patients were considered to have simple silicosis (93.4%) and seven to have progressive massive fibrosis (PMF) (6.6%). After a mean follow-up of 4.01 ± 2.1 years, disease in 56% of patients had progressed two or more International Labour Office subcategories, and the number of patients with PMF had increased to 40 (37.7%). Regarding lung function, there was a decrease in FVC and FEV1, with an average decrease of 86.8 and 83.4 mL per year, respectively; in 25% of patients, the annual decrease was > 157 mL in FVC and > 133 mL in FEV1. Multivariable analysis showed that lower FVC at diagnosis and longer duration of exposure to silica were associated with progression to PMF. INTERPRETATION: Artificial stone silicosis rapidly progresses to PMF even following exposure cessation, and a significant percentage of patients experience a very rapid decrease in lung function.
BACKGROUND:Silicosis is rapidly emerging in high-income countries in relation to the replacement of natural stone with artificial stone, especially in the manufacturing and installation of kitchen and bathroom countertops. Progression of this form of silicosis following the cessation of exposure is unknown. RESEARCH QUESTION: The objective of this study was to determine the radiologic progression and lung function in individuals with artificial stone silicosis. STUDY DESIGN AND METHODS: Between 2009 and 2018, a total of 106 patients were diagnosed with artificial stone silicosis in the Bay of Cádiz area (southern Spain), 14.15% by using biopsy results and the remainder according to chest radiography and high-resolution CT imaging. Follow-up consisted of respiratory function tests and radiographic studies. All patients stopped working in the stone industry following diagnosis. RESULTS: All patients were men; their mean ± SD age at diagnosis was 36.2 ± 7.0 years, and the mean duration of exposure was 12.0 ± 4.3 years. At diagnosis, 99 patients were considered to have simple silicosis (93.4%) and seven to have progressive massive fibrosis (PMF) (6.6%). After a mean follow-up of 4.01 ± 2.1 years, disease in 56% of patients had progressed two or more International Labour Office subcategories, and the number of patients with PMF had increased to 40 (37.7%). Regarding lung function, there was a decrease in FVC and FEV1, with an average decrease of 86.8 and 83.4 mL per year, respectively; in 25% of patients, the annual decrease was > 157 mL in FVC and > 133 mL in FEV1. Multivariable analysis showed that lower FVC at diagnosis and longer duration of exposure to silica were associated with progression to PMF. INTERPRETATION:Artificial stone silicosis rapidly progresses to PMF even following exposure cessation, and a significant percentage of patients experience a very rapid decrease in lung function.
Authors: Alejandro García-Núñez; Gema Jiménez-Gómez; Antonio Hidalgo-Molina; Juan Antonio Córdoba-Doña; Antonio León-Jiménez; Antonio Campos-Caro Journal: Sci Rep Date: 2022-05-17 Impact factor: 4.996
Authors: Antonio León-Jiménez; José M Mánuel; Marcial García-Rojo; Marina G Pintado-Herrera; José Antonio López-López; Antonio Hidalgo-Molina; Rafael García; Pedro Muriel-Cueto; Nieves Maira-González; Daniel Del Castillo-Otero; Francisco M Morales Journal: Part Fibre Toxicol Date: 2021-11-22 Impact factor: 9.400
Authors: Ryan F Hoy; Mohamed F Jeebhay; Catherine Cavalin; Weihong Chen; Robert A Cohen; Elizabeth Fireman; Leonard H T Go; Antonio León-Jiménez; Alfredo Menéndez-Navarro; Marcos Ribeiro; Paul-André Rosental Journal: Respirology Date: 2022-03-18 Impact factor: 6.175
Authors: Simon H Apte; Maxine E Tan; Viviana P Lutzky; Tharushi A De Silva; Andreas Fiene; Justin Hundloe; David Deller; Clair Sullivan; Peter T Bell; Daniel C Chambers Journal: Respirology Date: 2022-02-17 Impact factor: 6.175