Literature DB >> 32562974

Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis.

Vikas Arige1, David I Yule2.   

Abstract

We highlight a recent paper which documents the important role that Ca2+ release through type-1 Inositol 1,4,5-trisphosphate receptor (IP3R1) plays in the acute regulation by glucagon of gluconeogenesis in hepatocytes. The specificity is likely the result of discrete localization close to mitochondria and PKA-dependent phosphorylation of IP3R1 which enhances Ca2+ release.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Glucagon signaling; Gluconeogenesis; Hepatocytes; Inositol 1,4,5-trisphosphate receptors; PKA-phosphorylation

Mesh：

Substances：

Year:  2020        PMID： 32562974      PMCID： PMC8265827          DOI： 10.1016/j.ceca.2020.102243

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  10 in total

1.  IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

Authors:  Akira Futatsugi; Takeshi Nakamura; Maki K Yamada; Etsuko Ebisui; Kyoko Nakamura; Keiko Uchida; Tetsuya Kitaguchi; Hiromi Takahashi-Iwanaga; Tetsuo Noda; Jun Aruga; Katsuhiko Mikoshiba
Journal:  Science       Date:  2005-09-30       Impact factor: 47.728

2.  The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes.

Authors:  Keiji Hirata; Thomas Pusl; Allison F O'Neill; Jonathan A Dranoff; Michael H Nathanson
Journal:  Gastroenterology       Date:  2002-04       Impact factor: 22.682

3.  Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

Authors:  Lale Ozcan; Catherine C L Wong; Gang Li; Tao Xu; Utpal Pajvani; Sung Kyu Robin Park; Anetta Wronska; Bi-Xing Chen; Andrew R Marks; Akiyoshi Fukamizu; Johannes Backs; Harold A Singer; John R Yates; Domenico Accili; Ira Tabas
Journal:  Cell Metab       Date:  2012-04-12       Impact factor: 27.287

Review 4.  Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.

Authors:  David I Yule; Matthew J Betzenhauser; Suresh K Joseph
Journal:  Cell Calcium       Date:  2010-05-26       Impact factor: 6.817

Review 5.  The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic.

Authors:  Ido Goldstein; Gordon L Hager
Journal:  Endocrinology       Date:  2018-01-01       Impact factor: 4.736

6.  Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor.

Authors:  Larry E Wagner; Wen-Hong Li; Suresh K Joseph; David I Yule
Journal:  J Biol Chem       Date:  2004-08-11       Impact factor: 5.157

7.  Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

Authors:  Yiguo Wang; Gang Li; Jason Goode; Jose C Paz; Kunfu Ouyang; Robert Screaton; Wolfgang H Fischer; Ju Chen; Ira Tabas; Marc Montminy
Journal:  Nature       Date:  2012-04-08       Impact factor: 49.962

8.  Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

Authors:  Ana Paula Arruda; Benedicte M Pers; Güneş Parlakgül; Ekin Güney; Karen Inouye; Gökhan S Hotamisligil
Journal:  Nat Med       Date:  2014-11-24       Impact factor: 53.440

9.  IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

Authors:  Adam Bartok; David Weaver; Tünde Golenár; Zuzana Nichtova; Máté Katona; Száva Bánsághi; Kamil J Alzayady; V Kaye Thomas; Hideaki Ando; Katsuhiko Mikoshiba; Suresh K Joseph; David I Yule; György Csordás; György Hajnóczky
Journal:  Nat Commun       Date:  2019-08-19       Impact factor: 14.919

10.  Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.

Authors:  Rachel J Perry; Dongyan Zhang; Mateus T Guerra; Allison L Brill; Leigh Goedeke; Ali R Nasiri; Aviva Rabin-Court; Yongliang Wang; Liang Peng; Sylvie Dufour; Ye Zhang; Xian-Man Zhang; Gina M Butrico; Keshia Toussaint; Yuichi Nozaki; Gary W Cline; Kitt Falk Petersen; Michael H Nathanson; Barbara E Ehrlich; Gerald I Shulman
Journal:  Nature       Date:  2020-03-04       Impact factor: 49.962
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.