| Literature DB >> 32561043 |
Hironobu Yanagie1, Masashi Yanagawa2, Tsuyoshi Higuchi3, Ryouji Mizumachi3, Mitsuteru Fujihara4, Yasuyuki Morishita5, Yuriko Sakurai6, Kikue Mouri6, Novriana Dewi6, Yasumasa Nonaka7, Atsuko Shinohara8, Takehisa Matsukawa9, Ayano Kubota9, Kazuhito Yokoyama9, Minoru Suzuki10, Shin-Ichiro Masunaga10, Yohinori Sakurai10, Hiroki Tanaka10, Koji Ono11, Haruo Yamauchi12, Minoru Ono12, Jun Nakajima13, Shushi Higashi14, Hiroyuki Takahashi15.
Abstract
We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as 10B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injection of 10BSH-entrapped WOW were performed in rabbits and pig, and no side effects were observed. We hope to proceed to the preclinical and clinical studies for further evaluation of 10B compound as multidisciplinary treatments for HCC.Entities:
Keywords: BNCT; Hepatocellular carcinoma; Intra-arterial injection; Mixing medical device; WOW emulsion
Year: 2020 PMID： 32561043 DOI： 10.1016/j.apradiso.2020.109202
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513