Literature DB >> 32560227

Vaccines and Therapies in Development for SARS-CoV-2 Infections.

David Wu1, Raghuram Koganti1, Upendra P Lambe2, Tejabhiram Yadavalli1, Shyam S Nandi2, Deepak Shukla1,3.   

Abstract

The current COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. The virus causes severe respiratory symptoms which manifest disproportionately in the elderly. Currently, there are over 6.5 million cases and 380,000 deaths reported. Given the current severity of the outbreak, there is a great need for antiviral therapies and vaccines to treat and prevent COVID-19. In this review, we provide an overview of SARS-CoV-2 and discuss the emerging therapies and vaccines that show promise in combating COVID-19. We also highlight potential viral targets that could be exploited by researchers and drug manufacturers.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; coronavirus; therapies; vaccines

Year:  2020        PMID： 32560227     DOI： 10.3390/jcm9061885

Source DB:  PubMed          Journal:  J Clin Med        ISSN： 2077-0383            Impact factor:   4.241


  12 in total

Review 1.  An Overview of SARS-CoV-2 Molecular Diagnostics in Europe.

Authors:  Emma Davies; Hamzah Z Farooq; Benjamin Brown; Peter Tilston; Ashley McEwan; Andrew Birtles; Robert William O'Hara; Shazaad Ahmad; Nicholas Machin; Louise Hesketh; Malcolm Guiver
Journal:  Clin Lab Med       Date:  2022-03-08       Impact factor: 2.172

2.  Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives.

Authors:  Ritesh Tandon; Joshua S Sharp; Fuming Zhang; Vitor H Pomin; Nicole M Ashpole; Dipanwita Mitra; Martin G McCandless; Weihua Jin; Hao Liu; Poonam Sharma; Robert J Linhardt
Journal:  J Virol       Date:  2021-01-13       Impact factor: 5.103

Review 3.  Review on Up-to-Date Status of Candidate Vaccines for COVID-19 Disease.

Authors:  Tafere Mulaw Belete
Journal:  Infect Drug Resist       Date:  2021-01-19       Impact factor: 4.003

4.  Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication.

Authors:  Milan Dejmek; Eva Konkoľová; Luděk Eyer; Petra Straková; Pavel Svoboda; Michal Šála; Kateřina Krejčová; Daniel Růžek; Evzen Boura; Radim Nencka
Journal:  Viruses       Date:  2021-08-11       Impact factor: 5.048

5.  Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro.

Authors:  Paul S Kwon; Hanseul Oh; Seok-Joon Kwon; Weihua Jin; Fuming Zhang; Keith Fraser; Jung Joo Hong; Robert J Linhardt; Jonathan S Dordick
Journal:  Cell Discov       Date:  2020-07-24       Impact factor: 10.849

6.  Prevalence of SARS-CoV-2 in human post-mortem ocular tissues.

Authors:  Onkar B Sawant; Sneha Singh; Robert Emery Wright; Kayla M Jones; Michael S Titus; Eugene Dennis; Eric Hicks; Parag A Majmudar; Ashok Kumar; Shahzad I Mian
Journal:  Ocul Surf       Date:  2020-11-08       Impact factor: 5.033

7.  Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.

Authors:  Kanika Aggarwal; Aniruddha Agarwal; Nishant Jaiswal; Neha Dahiya; Alka Ahuja; Sarakshi Mahajan; Louis Tong; Mona Duggal; Meenu Singh; Rupesh Agrawal; Vishali Gupta
Journal:  PLoS One       Date:  2020-11-05       Impact factor: 3.240

8.  SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.

Authors:  Thomas Mandel Clausen; Daniel R Sandoval; Charlotte B Spliid; Jessica Pihl; Hailee R Perrett; Chelsea D Painter; Anoop Narayanan; Sydney A Majowicz; Elizabeth M Kwong; Rachael N McVicar; Bryan E Thacker; Charles A Glass; Zhang Yang; Jonathan L Torres; Gregory J Golden; Phillip L Bartels; Ryan N Porell; Aaron F Garretson; Logan Laubach; Jared Feldman; Xin Yin; Yuan Pu; Blake M Hauser; Timothy M Caradonna; Benjamin P Kellman; Cameron Martino; Philip L S M Gordts; Sumit K Chanda; Aaron G Schmidt; Kamil Godula; Sandra L Leibel; Joyce Jose; Kevin D Corbett; Andrew B Ward; Aaron F Carlin; Jeffrey D Esko
Journal:  Cell       Date:  2020-09-14       Impact factor: 41.582

9.  Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms.

Authors:  Daniel M Shadrack; Geradius Deogratias; Lucy W Kiruri; Hulda S Swai; John-Mary Vianney; Stephen S Nyandoro
Journal:  J Mol Graph Model       Date:  2021-02-23       Impact factor: 2.518

Review 10.  COVID-19: Myths and Reality.

Authors:  Larisa V Kordyukova; Andrey V Shanko
Journal:  Biochemistry (Mosc)       Date:  2021-07       Impact factor: 2.487
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