| Literature DB >> 32557646 |
Jie Bin1,2, Shaolin Nie1,2, Ziyuan Tang1,2, Anding Kang1,2, Zhongping Fu1,2, Yingbin Hu1,2, Qianjin Liao1,3, Wei Xiong1,4, Yujuan Zhou1, Yanyan Tang1,2,3, Jiarui Jiang1,2.
Abstract
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. In terms of cancer-related death, colon cancer ranks second and third among men and women, respectively, and the incidence is increasing annually. Accumulating evidence have indicated that long noncoding RNA (lncRNA) plays an important role in tumorigenesis. In this study, we found that lncRNA EPB41L4A-AS1 was highly expressed in CRC tissues and was associated with poor prognosis and tumor metastasis in patients with CRC. In vitro studies showed that the knockdown of EPB41L4A-AS1 inhibited the proliferation, migration, invasion, and epithelial-mesenchymal transition of CRC cells. Mechanically, we found that EPB41L4A-AS1 may participate in the development of CRC by activating the Rho/Rho-associated protein kinase signaling pathway. Collectively, these results demonstrated that EPB41L4A-AS1 can promote the proliferation, invasion, and migration of CRC, and it may be a novel biomarker for the diagnosis and targeted treatment of CRC.Entities:
Keywords: EPB41L4A-AS1; colorectal cancer; epithelial-mesenchymal transition; long noncoding RNA
Year: 2020 PMID： 32557646 DOI： 10.1002/jcp.29880
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384