Muhammad Atif1, Wajiha Ahmad1, Nafees Ahmad2, Iram Malik1, Sajjad Sarwar3. 1. Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan. 2. Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Balochistan, Pakistan. 3. Department of Pulmonology, Bahawal Victoria Hospital, Bahawalpur, Punjab, Pakistan.
Abstract
BACKGROUND: This study aims to evaluate the treatment outcomes and factors associated with unsuccessful treatment outcomes among multidrug-resistant TB (MDR-TB) patients. METHOD: This was a retrospective observational study conducted at the Bahawal Victoria Hospital, Bahawalpur, Pakistan. The sociodemographic, clinical and treatment-related data of MDR-TB patients registered at the study site between June 2014 and December 2016 were retrospectively collected. Patients' treatment outcomes were categorized on the basis of WHO-recommended criteria. Multivariate binary logistic regression analysis was used to find the independent factors associated with unsuccessful treatment outcomes. RESULTS: Out of 179 MDR-TB patients, 106 (59.2%) completed their treatment successfully. The remaining 73 patients (40.8%) had unsuccessful treatment outcomes, among whom 45 (25.1%) died, while 18 (10.1%) were lost to follow-up. Factors associated with unsuccessful treatment outcomes included age ≥40 y (AOR 4.310; p = 0.006), unsuccessful interim treatment outcomes (AOR 5.810; p = 0.032), occurrence of adverse events (AOR 0.290; p = 0.029) and ofloxacin resistance (AOR 2.952; p = 0.042). CONCLUSION: The treatment success rate among the selected cohort of MDR-TB patients was less than the target of ≥75% set by the WHO in the End TB Strategy. The lower treatment success rate at the study site requires urgent attention from clinicians and program managers.
BACKGROUND: This study aims to evaluate the treatment outcomes and factors associated with unsuccessful treatment outcomes among multidrug-resistant TB (MDR-TB) patients. METHOD: This was a retrospective observational study conducted at the Bahawal Victoria Hospital, Bahawalpur, Pakistan. The sociodemographic, clinical and treatment-related data of MDR-TBpatients registered at the study site between June 2014 and December 2016 were retrospectively collected. Patients' treatment outcomes were categorized on the basis of WHO-recommended criteria. Multivariate binary logistic regression analysis was used to find the independent factors associated with unsuccessful treatment outcomes. RESULTS: Out of 179 MDR-TBpatients, 106 (59.2%) completed their treatment successfully. The remaining 73 patients (40.8%) had unsuccessful treatment outcomes, among whom 45 (25.1%) died, while 18 (10.1%) were lost to follow-up. Factors associated with unsuccessful treatment outcomes included age ≥40 y (AOR 4.310; p = 0.006), unsuccessful interim treatment outcomes (AOR 5.810; p = 0.032), occurrence of adverse events (AOR 0.290; p = 0.029) and ofloxacin resistance (AOR 2.952; p = 0.042). CONCLUSION: The treatment success rate among the selected cohort of MDR-TBpatients was less than the target of ≥75% set by the WHO in the End TB Strategy. The lower treatment success rate at the study site requires urgent attention from clinicians and program managers.
Authors: Farman Ullah Khan; Asim Ur Rehman; Faiz Ullah Khan; Khezar Hayat; Amjad Khan; Nafees Ahmad; Jie Chang; Usman Rashid Malik; Yu Fang Journal: Int J Environ Res Public Health Date: 2022-01-29 Impact factor: 3.390
Authors: Muhammad Atif; Waqar Ahmed; Muhammad Nouman Iqbal; Nafees Ahmad; Wajiha Ahmad; Iram Malik; Yaser Mohammed Al-Worafi Journal: Front Med (Lausanne) Date: 2022-03-01
Authors: Abdul Wahid; Abdul Ghafoor; Abdul Wali Khan; Yaser Mohammed Al-Worafi; Abdullah Latif; Nisar Ahmed Shahwani; Muhammad Atif; Fahad Saleem; Nafees Ahmad Journal: Front Pharmacol Date: 2022-09-06 Impact factor: 5.988