Refik Bademci1, Mümin Alper Erdoğan2, Ali Yücel Kara2, Gürkan Yiğittürk3, Oytun Erbaş4. 1. Assistant Professor, Department of General Surgery, Istanbul Medipol University, Istanbul, Turkey. Conception of the study, acquisition of data, manuscript writing, critical revision. 2. Assistant Professor, Izmir Katip Çelebi University, Faculty of Medicine, Department of Physiology, Izmir, Turkey. Conception of the study, acquisition of data, methodology, manuscript writing. 3. Assistant Professor, Izmir Katip Çelebi University, Faculty of Medicine, Department of Physiology, Izmir, Turkey. Manuscript writing, critical revision. 4. Assistant Professor, Ege University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey. Investigation, manuscript writing, critical revision.
Abstract
PURPOSE: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. METHODS: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. RESULTS: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000). CONCLUSION: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.
PURPOSE: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. METHODS: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. RESULTS: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000). CONCLUSION: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.
Authors: Brian G Feagan; David T Rubin; Silvio Danese; Severine Vermeire; Brihad Abhyankar; Serap Sankoh; Alexandra James; Michael Smyth Journal: Clin Gastroenterol Hepatol Date: 2016-09-14 Impact factor: 11.382
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Authors: Axel Dignass; James O Lindsay; Andreas Sturm; Alastair Windsor; Jean-Frederic Colombel; Mathieu Allez; Gert D'Haens; André D'Hoore; Gerassimos Mantzaris; Gottfried Novacek; Tom Oresland; Walter Reinisch; Miquel Sans; Eduard Stange; Severine Vermeire; Simon Travis; Gert Van Assche Journal: J Crohns Colitis Date: 2012-10-03 Impact factor: 10.020