Literature DB >> 32555134

Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020.

Erin K Stokes1, Laura D Zambrano1, Kayla N Anderson1, Ellyn P Marder1, Kala M Raz1, Suad El Burai Felix1, Yunfeng Tie1, Kathleen E Fullerton1.   

Abstract

The coronavirus disease 2019 (COVID-19) pandemic resulted in 5,817,385 reported cases and 362,705 deaths worldwide through May, 30, 2020,† including 1,761,503 aggregated reported cases and 103,700 deaths in the United States.§ Previous analyses during February-early April 2020 indicated that age ≥65 years and underlying health conditions were associated with a higher risk for severe outcomes, which were less common among children aged <18 years (1-3). This report describes demographic characteristics, underlying health conditions, symptoms, and outcomes among 1,320,488 laboratory-confirmed COVID-19 cases individually reported to CDC during January 22-May 30, 2020. Cumulative incidence, 403.6 cases per 100,000 persons,¶ was similar among males (401.1) and females (406.0) and highest among persons aged ≥80 years (902.0). Among 599,636 (45%) cases with known information, 33% of persons were Hispanic or Latino of any race (Hispanic), 22% were non-Hispanic black (black), and 1.3% were non-Hispanic American Indian or Alaska Native (AI/AN). Among 287,320 (22%) cases with sufficient data on underlying health conditions, the most common were cardiovascular disease (32%), diabetes (30%), and chronic lung disease (18%). Overall, 184,673 (14%) patients were hospitalized, 29,837 (2%) were admitted to an intensive care unit (ICU), and 71,116 (5%) died. Hospitalizations were six times higher among patients with a reported underlying condition (45.4%) than those without reported underlying conditions (7.6%). Deaths were 12 times higher among patients with reported underlying conditions (19.5%) compared with those without reported underlying conditions (1.6%). The COVID-19 pandemic continues to be severe, particularly in certain population groups. These preliminary findings underscore the need to build on current efforts to collect and analyze case data, especially among those with underlying health conditions. These data are used to monitor trends in COVID-19 illness, identify and respond to localized incidence increase, and inform policies and practices designed to reduce transmission in the United States.

Entities:  

Mesh:

Year:  2020        PMID: 32555134      PMCID: PMC7302472          DOI: 10.15585/mmwr.mm6924e2

Source DB:  PubMed          Journal:  MMWR Morb Mortal Wkly Rep        ISSN: 0149-2195            Impact factor:   17.586


The coronavirus disease 2019 (COVID-19) pandemic resulted in 5,817,385 reported cases and 362,705 deaths worldwide through May, 30, 2020, including 1,761,503 aggregated reported cases and 103,700 deaths in the United States. Previous analyses during February–early April 2020 indicated that age ≥65 years and underlying health conditions were associated with a higher risk for severe outcomes, which were less common among children aged <18 years (–). This report describes demographic characteristics, underlying health conditions, symptoms, and outcomes among 1,320,488 laboratory-confirmed COVID-19 cases individually reported to CDC during January 22–May 30, 2020. Cumulative incidence, 403.6 cases per 100,000 persons, was similar among males (401.1) and females (406.0) and highest among persons aged ≥80 years (902.0). Among 599,636 (45%) cases with known information, 33% of persons were Hispanic or Latino of any race (Hispanic), 22% were non-Hispanic black (black), and 1.3% were non-Hispanic American Indian or Alaska Native (AI/AN). Among 287,320 (22%) cases with sufficient data on underlying health conditions, the most common were cardiovascular disease (32%), diabetes (30%), and chronic lung disease (18%). Overall, 184,673 (14%) patients were hospitalized, 29,837 (2%) were admitted to an intensive care unit (ICU), and 71,116 (5%) died. Hospitalizations were six times higher among patients with a reported underlying condition (45.4%) than those without reported underlying conditions (7.6%). Deaths were 12 times higher among patients with reported underlying conditions (19.5%) compared with those without reported underlying conditions (1.6%). The COVID-19 pandemic continues to be severe, particularly in certain population groups. These preliminary findings underscore the need to build on current efforts to collect and analyze case data, especially among those with underlying health conditions. These data are used to monitor trends in COVID-19 illness, identify and respond to localized incidence increase, and inform policies and practices designed to reduce transmission in the United States. State and territorial health departments report daily aggregate counts of COVID-19 cases and deaths to CDC; these were tabulated according to date of report to examine reporting trends during January 22–May 30. In addition to aggregate counts, individual COVID-19 case reports were submitted via a CDC COVID-19 case report form** and the National Notifiable Diseases Surveillance System (NNDSS). Jurisdictions voluntarily report confirmed and probable cases from reports submitted by health care providers and laboratories. A laboratory-confirmed COVID-19 case was defined as a person with a positive test result for SARS-CoV-2, the virus that causes COVID-19, from a respiratory specimen, using real-time reverse transcription–polymerase chain reaction testing. COVID-19 case data reported from 50 states, New York City, and the District of Columbia were analyzed to examine reported demographic characteristics, underlying health conditions, clinical signs and symptoms, and severe outcomes, including hospitalization, ICU admission, and death. Data were missing for age, sex, and race or ethnicity in <1%, 1%, and 55% of reports, respectively.*** Cases reported without sex or age data were excluded from this analysis as were cases meeting only the probable case definition, along with persons repatriated to the United States from Wuhan, China, or the Diamond Princess cruise ship. Cumulative incidence was estimated using 2018 population estimates. Because of the high prevalence of missing race and ethnicity data, estimates of incidence and proportions of underlying health conditions, symptoms, and severe outcomes by race and ethnicity were not described. Analyses are descriptive and statistical comparisons were not performed. CDC received notification of the first case of laboratory-confirmed COVID-19 in the United States on January 22, 2020. As of May 30, an aggregate 1,761,503 U.S. COVID-19 cases and 103,700 deaths had been reported (Figure). The 7-day moving average number of new daily cases peaked on April 12 (31,994) and deaths peaked on April 21 (2,856). As of May 30, the 7-day moving average numbers of new cases were 19,913 per day and deaths were 950 per day.
FIGURE

Daily number of COVID-19 cases,,, (A) and COVID-19–associated deaths** (B) reported to CDC — United States, January 22–May 30, 2020

Abbreviation: COVID-19 = coronavirus disease 2019.

* From April 14, 2020, aggregate case counts reported by CDC included deaths attributable to both confirmed and probable COVID-19 as classified by reporting jurisdictions, using the Council of State and Territorial Epidemiologists position statement Interim-ID-20-01 (https://cdn.ymaws.com/www.cste.org/resource/resmgr/2020ps/interim-20-id-01_covid-19.pdf).

† The upper quartile of the lag between onset date and reporting to CDC was 15 days.

§ The daily number of deaths reported by jurisdictions on April 14 includes 4,141 deaths newly classified as probable.

¶ Overall <1% of cases reported in aggregate to CDC were classified as probable.

** Overall 3.1% of deaths reported in aggregate to CDC were classified as occurring in persons with probable cases.

Daily number of COVID-19 cases,,, (A) and COVID-19–associated deaths** (B) reported to CDC — United States, January 22–May 30, 2020 Abbreviation: COVID-19 = coronavirus disease 2019. * From April 14, 2020, aggregate case counts reported by CDC included deaths attributable to both confirmed and probable COVID-19 as classified by reporting jurisdictions, using the Council of State and Territorial Epidemiologists position statement Interim-ID-20-01 (https://cdn.ymaws.com/www.cste.org/resource/resmgr/2020ps/interim-20-id-01_covid-19.pdf). † The upper quartile of the lag between onset date and reporting to CDC was 15 days. § The daily number of deaths reported by jurisdictions on April 14 includes 4,141 deaths newly classified as probable. ¶ Overall <1% of cases reported in aggregate to CDC were classified as probable. ** Overall 3.1% of deaths reported in aggregate to CDC were classified as occurring in persons with probable cases. Among the 1,761,503 aggregate cases reported to CDC during January 22–May 30, individual case reports for 1,406,098 were submitted to CDC case surveillance. After exclusions, data for 1,320,488 (94%) cases were analyzed. Median age was 48 years (interquartile range = 33–63 years). Incidence was 403.6 cases per 100,000 population (Table 1) and was similar among females (406.0) and males (401.1).**** Incidence was higher among persons aged 40–49 years (541.6) and 50–59 years (550.5) than among those aged 60–69 years (478.4) and 70–79 years (464.2). Incidence was highest among persons aged ≥80 years (902.0) and lowest among children aged ≤9 years (51.1). Among the 599,636 (45%) cases with information on both race and ethnicity, 36% of persons were non-Hispanic white, 33% were Hispanic, 22% were black, 4% were non-Hispanic Asian, 4% were non-Hispanic, other or multiple race, 1.3% were AI/AN, and <1% were non-Hispanic Native Hawaiian or other Pacific Islander.
TABLE 1

Reported laboratory-confirmed COVID-19 cases and estimated cumulative incidence,* by sex and age group — United States, January 22–May 30, 2020

Age group (yrs)Males
Females
Total
No. (%)Cumulative incidence*No. (%)Cumulative incidence*No. (%)Cumulative incidence*
0–9
10,743 (1.7)
52.5
9,715 (1.4)
49.7
20,458 (1.5)
51.1
10–19
24,302 (3.8)
113.4
24,943 (3.7)
121.4
49,245 (3.7)
117.3
20–29
85,913 (13.3)
370.0
96,556 (14.3)
434.6
182,469 (13.8)
401.6
30–39
108,319 (16.8)
492.8
106,530 (15.8)
490.5
214,849 (16.3)
491.6
40–49
109,745 (17.0)
547.0
109,394 (16.2)
536.2
219,139 (16.6)
541.6
50–59
119,152 (18.4)
568.8
116,622 (17.3)
533.0
235,774 (17.9)
550.5
60–69
93,596 (14.5)
526.9
85,411 (12.7)
434.6
179,007 (13.6)
478.4
70–79
53,194 (8.2)
513.7
52,058 (7.7)
422.7
105,252 (8.0)
464.2
≥80
41,394 (6.4)
842.0
72,901 (10.8)
940.0
114,295 (8.7)
902.0
All ages 646,358 (100.0) 401.1 674,130 (100.0) 406.0 1,320,488 (100.0) 403.6

Abbreviation: COVID-19 = coronavirus disease 2019.

* Per 100,000 population.

The analytic dataset excludes cases reported through case surveillance that were missing information on sex (n = 19,918) or age (n = 2,379).

Abbreviation: COVID-19 = coronavirus disease 2019. * Per 100,000 population. The analytic dataset excludes cases reported through case surveillance that were missing information on sex (n = 19,918) or age (n = 2,379). Symptom status (symptomatic versus asymptomatic) was reported for 616,541 (47%) cases; among these, 22,007 (4%) were asymptomatic. Among 373,883 (28%) cases with data on individual symptoms, 70% noted fever, cough, or shortness of breath; 36% reported muscle aches, and 34% reported headache (Table 2). Overall, 31,191 (8%) persons reported loss of smell or taste. Among patients aged ≥80 years, 60% reported fever, cough, or shortness of breath. No other symptoms were reported by >10% of persons in this age group.
TABLE 2

Reported underlying health conditions* and symptoms among persons with laboratory-confirmed COVID-19, by sex and age group — United States, January 22–May 30, 2020

CharacteristicNo. (%)
TotalSex
Age group (yrs)
MaleFemale≤910–1920–2930–3940–4950–5960–6970–79≥80
Total population
1,320,488
646,358
674,130
20,458
49,245
182,469
214,849
219,139
235,774
179,007
105,252
114,295
Underlying health condition§
Known underlying medical condition status*
287,320 (21.8)
138,887 (21.5)
148,433 (22.0)
2,896 (14.2)
7,123 (14.5)
27,436 (15.0)
33,483 (15.6)
40,572 (18.5)
54,717 (23.2)
50,125 (28.0)
34,400 (32.7)
36,568 (32.0)
Any cardiovascular disease
92,546 (32.2)
47,567 (34.2)
44,979 (30.3)
78 (2.7)
164 (2.3)
1,177 (4.3)
3,588 (10.7)
8,198 (20.2)
16,954 (31.0)
21,466 (42.8)
18,763 (54.5)
22,158 (60.6)
Any chronic lung disease
50,148 (17.5)
20,930 (15.1)
29,218 (19.7)
363 (12.5)
1,285 (18)
4,537 (16.5)
5,110 (15.3)
6,127 (15.1)
8,722 (15.9)
9,200 (18.4)
7,436 (21.6)
7,368 (20.1)
Renal disease
21,908 (7.6)
12,144 (8.7)
9,764 (6.6)
21 (0.7)
34 (0.5)
204 (0.7)
587 (1.8)
1,273 (3.1)
2,789 (5.1)
4,764 (9.5)
5,401 (15.7)
6,835 (18.7)
Diabetes
86,737 (30.2)
45,089 (32.5)
41,648 (28.1)
12 (0.4)
225 (3.2)
1,409 (5.1)
4,106 (12.3)
9,636 (23.8)
19,589 (35.8)
22,314 (44.5)
16,594 (48.2)
12,852 (35.1)
Liver disease
3,953 (1.4)
2,439 (1.8)
1,514 (1.0)
5 (0.2)
19 (0.3)
132 (0.5)
390 (1.2)
573 (1.4)
878 (1.6)
1,074 (2.1)
583 (1.7)
299 (0.8)
Immunocompromised
15,265 (5.3)
7,345 (5.3)
7,920 (5.3)
61 (2.1)
146 (2.0)
646 (2.4)
1,253 (3.7)
2,005 (4.9)
3,190 (5.8)
3,421 (6.8)
2,486 (7.2)
2,057 (5.6)
Neurologic/Neurodevelopmental disability
13,665 (4.8)
6,193 (4.5)
7,472 (5.0)
41 (1.4)
113 (1.6)
395 (1.4)
533 (1.6)
734 (1.8)
1,338 (2.4)
2,006 (4.0)
2,759 (8.0)
5,746 (15.7)
Symptom§
Known symptom status
373,883 (28.3)
178,223 (27.6)
195,660 (29.0)
5,188 (25.4)
12,689 (25.8)
51,464 (28.2)
59,951 (27.9)
62,643 (28.6)
70,040 (29.7)
52,178 (29.1)
28,583 (27.2)
31,147 (27.3)
Fever, cough, or shortness of breath
260,706 (69.7)
125,768 (70.6)
134,938 (69.0)
3,278 (63.2)
7,584 (59.8)
35,072 (68.1)
42,016 (70.1)
45,361 (72.4)
51,283 (73.2)
37,701 (72.3)
19,583 (68.5)
18,828 (60.4)
Fever††
161,071 (43.1)
80,578 (45.2)
80,493 (41.1)
2,404 (46.3)
4,443 (35.0)
20,381 (39.6)
25,887 (43.2)
28,407 (45.3)
32,375 (46.2)
23,591 (45.2)
12,190 (42.6)
11,393 (36.6)
Cough
187,953 (50.3)
89,178 (50.0)
98,775 (50.5)
1,912 (36.9)
5,257 (41.4)
26,284 (51.1)
31,313 (52.2)
34,031 (54.3)
38,305 (54.7)
27,150 (52.0)
12,837 (44.9)
10,864 (34.9)
Shortness of breath
106,387 (28.5)
49,834 (28.0)
56,553 (28.9)
339 (6.5)
2,070 (16.3)
13,649 (26.5)
16,851 (28.1)
18,978 (30.3)
21,327 (30.4)
16,018 (30.7)
8,971 (31.4)
8,184 (26.3)
Myalgia
135,026 (36.1)
61,922 (34.7)
73,104 (37.4)
537 (10.4)
3,737 (29.5)
21,153 (41.1)
26,464 (44.1)
28,064 (44.8)
28,594 (40.8)
17,360 (33.3)
6,015 (21.0)
3,102 (10.0)
Runny nose
22,710 (6.1)
9,900 (5.6)
12,810 (6.5)
354 (6.8)
1,025 (8.1)
4,591 (8.9)
4,406 (7.3)
4,141 (6.6)
4,100 (5.9)
2,671 (5.1)
923 (3.2)
499 (1.6)
Sore throat
74,840 (20.0)
31,244 (17.5)
43,596 (22.3)
664 (12.8)
3,628 (28.6)
14,493 (28.2)
14,855 (24.8)
14,490 (23.1)
13,930 (19.9)
8,192 (15.7)
2,867 (10.0)
1,721 (5.5)
Headache
128,560 (34.4)
54,721 (30.7)
73,839 (37.7)
785 (15.1)
5,315 (41.9)
23,723 (46.1)
26,142 (43.6)
26,245 (41.9)
26,057 (37.2)
14,735 (28.2)
4,163 (14.6)
1,395 (4.5)
Nausea/Vomiting
42,813 (11.5)
16,549 (9.3)
26,264 (13.4)
506 (9.8)
1,314 (10.4)
6,648 (12.9)
7,661 (12.8)
8,091 (12.9)
8,737 (12.5)
5,953 (11.4)
2,380 (8.3)
1,523 (4.9)
Abdominal pain
28,443 (7.6)
11,553 (6.5)
16,890 (8.6)
349 (6.7)
978 (7.7)
4,211 (8.2)
5,150 (8.6)
5,531 (8.8)
6,134 (8.8)
3,809 (7.3)
1,449 (5.1)
832 (2.7)
Diarrhea
72,039 (19.3)
32,093 (18.0)
39,946 (20.4)
704 (13.6)
1,712 (13.5)
9,867 (19.2)
12,769 (21.3)
13,958 (22.3)
15,536 (22.2)
10,349 (19.8)
4,402 (15.4)
2,742 (8.8)
Loss of smell or taste 31,191 (8.3) 12,717 (7.1)18,474 (9.4)67 (1.3)1,257 (9.9)6,828 (13.3)6,907 (11.5)6,361 (10.2)5,828 (8.3)2,930 (5.6)775 (2.7)238 (0.8)

Abbreviation: COVID-19 = coronavirus disease 2019.

* Status of underlying health conditions known for 287,320 persons. Status was classified as “known” if any of the following conditions were reported as present or absent: diabetes mellitus, cardiovascular disease (including hypertension), severe obesity (body mass index ≥40 kg/m2), chronic renal disease, chronic liver disease, chronic lung disease, immunocompromising condition, autoimmune condition, neurologic condition (including neurodevelopmental, intellectual, physical, visual, or hearing impairment), psychologic/psychiatric condition, and other underlying medical condition not otherwise specified.

† Symptom status was known for 373,883 persons. Status was classified as “known” if any of the following symptoms were reported as present or absent: fever (measured >100.4°F [38°C] or subjective), cough, shortness of breath, wheezing, difficulty breathing, chills, rigors, myalgia, rhinorrhea, sore throat, chest pain, nausea or vomiting, abdominal pain, headache, fatigue, diarrhea (≥3 loose stools in a 24-hour period), or other symptom not otherwise specified on the form.

§ Responses include data from standardized fields supplemented with data from free-text fields. Information for persons with loss of smell or taste was exclusively extracted from a free-text field; therefore, persons exhibiting this symptom were likely underreported.

¶ Includes persons with reported hypertension.

** Includes all persons with at least one of these symptoms reported.

Persons were considered to have a fever if information on either measured or subjective fever variables if “yes” was reported for either variable.

Abbreviation: COVID-19 = coronavirus disease 2019. * Status of underlying health conditions known for 287,320 persons. Status was classified as “known” if any of the following conditions were reported as present or absent: diabetes mellitus, cardiovascular disease (including hypertension), severe obesity (body mass index ≥40 kg/m2), chronic renal disease, chronic liver disease, chronic lung disease, immunocompromising condition, autoimmune condition, neurologic condition (including neurodevelopmental, intellectual, physical, visual, or hearing impairment), psychologic/psychiatric condition, and other underlying medical condition not otherwise specified. † Symptom status was known for 373,883 persons. Status was classified as “known” if any of the following symptoms were reported as present or absent: fever (measured >100.4°F [38°C] or subjective), cough, shortness of breath, wheezing, difficulty breathing, chills, rigors, myalgia, rhinorrhea, sore throat, chest pain, nausea or vomiting, abdominal pain, headache, fatigue, diarrhea (≥3 loose stools in a 24-hour period), or other symptom not otherwise specified on the form. § Responses include data from standardized fields supplemented with data from free-text fields. Information for persons with loss of smell or taste was exclusively extracted from a free-text field; therefore, persons exhibiting this symptom were likely underreported. ¶ Includes persons with reported hypertension. ** Includes all persons with at least one of these symptoms reported. Persons were considered to have a fever if information on either measured or subjective fever variables if “yes” was reported for either variable. Among 287,320 (22%) cases with data on individual underlying health conditions, those most frequently reported were cardiovascular disease (32%), diabetes (30%), and chronic lung disease (18%) (Table 2); the reported proportions were similar among males and females. The frequency of conditions reported varied by age group: cardiovascular disease was uncommon among those aged ≤39 years but was reported in approximately half of the cases among persons aged ≥70 years. Among 63,896 females aged 15–44 years with known pregnancy status, 6,708 (11%) were reported to be pregnant. Among the 1,320,488 cases, outcomes for hospitalization, ICU admission, and death were available for 46%, 14%, and 36%, respectively. Overall, 184,673 (14%) patients were hospitalized, including 29,837 (2%) admitted to the ICU; 71,116 (5%) patients died (Table 3). Severe outcomes were more commonly reported for patients with reported underlying conditions. Hospitalizations were six times higher among patients with a reported underlying condition than those without reported underlying conditions (45.4% versus 7.6%). Deaths were 12 times higher among patients with reported underlying conditions compared with those without reported underlying conditions (19.5% versus 1.6%). The percentages of males who were hospitalized (16%), admitted to the ICU (3%), and who died (6%) were higher than were those for females (12%, 2%, and 5%, respectively). The percentage of ICU admissions was highest among persons with reported underlying conditions aged 60–69 years (11%) and 70–79 years (12%). Death was most commonly reported among persons aged ≥80 years regardless of the presence of underlying conditions (with underlying conditions 50%; without 30%).
TABLE 3

Reported hospitalizations,*, intensive care unit (ICU) admissions, and deaths among laboratory-confirmed COVID-19 patients with and without reported underlying health conditions, by sex and age — United States, January 22–May 30, 2020

Characteristic (no.)Outcome, no./total no. (%)††
Reported hospitalizations*,† (including ICU)
Reported ICU admission§
Reported deaths
Among all patientsAmong patients with reported underlying health conditionsAmong patients with no reported underlying health conditionsAmong all patientsAmong patients with reported underlying health conditionsAmong patients with no reported underlying health conditionsAmong all patientsAmong patients with reported underlying health conditionsAmong patients with no reported underlying health conditions
Sex
Male (646,358)
101,133/646,358 (15.6)
49,503/96,839 (51.1)
3,596/42,048 (8.6)
18,394/646,358 (2.8)
10,302/96,839 (10.6)
864/42,048 (2.1)
38,773/646,358 (6.0)
21,667/96,839 (22.4)
724/42,048 (1.7)
Female (674,130)
83,540/674,130 (12.4)
40,698/102,040 (39.9)
3,087/46,393 (6.7)
11,443/674,130 (1.7)
6,672/102,040 (6.5)
479/46,393 (1.0)
32,343/674,130 (4.8)
17,145/102,040 (16.8)
707/46,393 (1.5)
Age group (yrs)
≤9 (20,458)
848/20,458 (4.1)
138/619 (22.3)
84/2,277 (3.7)
141/20,458 (0.7)
31/619 (5.0)
16/2,277 (0.7)
13/20,458 (0.1)
4/619 (0.6)
2/2,277 (0.1)
10–19 (49,245)
1,234/49,245 (2.5)
309/2,076 (14.9)
115/5,047 (2.3)
216/49,245 (0.4)
72/2,076 (3.5)
17/5,047 (0.3)
33/49,245 (0.1)
16/2,076 (0.8)
4/5,047 (0.1)
20–29 (182,469)
6,704/182,469 (3.7)
1,559/8,906 (17.5)
498/18,530 (2.7)
864/182,469 (0.5)
300/8,906 (3.4)
56/18,530 (0.3)
273/182,469 (0.1)
122/8,906 (1.4)
24/18,530 (0.1)
30–39 (214,849)
12,570/214,849 (5.9)
3,596/14,854 (24.2)
828/18,629 (4.4)
1,879/214,849 (0.9)
787/14,854 (5.3)
135/18,629 (0.7)
852/214,849 (0.4)
411/14,854 (2.8)
21/18,629 (0.1)
40–49 (219,139)
19,318/219,139 (8.8)
7,151/24,161 (29.6)
1,057/16,411 (6.4)
3,316/219,139 (1.5)
1,540/24,161 (6.4)
208/16,411 (1.3)
2,083/219,139 (1.0)
1,077/24,161 (4.5)
58/16,411 (0.4)
50–59 (235,774)
31,588/235,774 (13.4)
14,639/40,297 (36.3)
1,380/14,420 (9.6)
5,986/235,774 (2.5)
3,335/40,297 (8.3)
296/14,420 (2.1)
5,639/235,774 (2.4)
3,158/40,297 (7.8)
131/14,420 (0.9)
60–69 (179,007)
39,422/179,007 (22.0)
21,064/42,206 (49.9)
1,216/7,919 (15.4)
7,403/179,007 (4.1)
4,588/42,206 (10.9)
291/7,919 (3.7)
11,947/179,007 (6.7)
7,050/42,206 (16.7)
187/7,919 (2.4)
70–79 (105,252)
35,844/105,252 (34.1)
20,451/31,601 (64.7)
780/2,799 (27.9)
5,939/105,252 (5.6)
3,771/31,601 (11.9)
199/2,799 (7.1)
17,510/105,252 (16.6)
10,008/31,601 (31.7)
286/2,799 (10.2)
≥80 (114,295)
37,145/114,295 (32.5)
21,294/34,159 (62.3)
725/2,409 (30.1)
4,093/114,295 (3.6)
2,550/34,159 (7.5)
125/2,409 (5.2)
32,766/114,295 (28.7)
16,966/34,159 (49.7)
718/2,409 (29.8)
Total (1,320,488) 184,673/1,320,488 (14.0) 90,201/198,879 (45.4) 6,683/88,441 (7.6) 29,837/1,320,488 (2.3) 16,974/198,879 (8.5) 1,343/88,441 (1.5) 71,116/1,320,488 (5.4) 38,812/198,879 (19.5) 1,431/88,441 (1.6)

Abbreviation: COVID-19 = coronavirus disease 2019.

* Hospitalization status was known for 600,860 (46%). Among 184,673 hospitalized patients, the presence of underlying health conditions was known for 96,884 (53%).

† Includes reported ICU admissions.

§ ICU admission status was known for 186,563 (14%) patients among the total case population, representing 34% of hospitalized patients. Among 29,837 patients admitted to the ICU, the status of underlying health conditions was known for 18,317 (61%).

¶ Death outcomes were known for 480,565 (36%) patients. Among 71,116 reported deaths through case surveillance, the status of underlying health conditions was known for 40,243 (57%) patients.

** Status of underlying health conditions was known for 287,320 (22%) patients. Status was classified as “known” if any of the following conditions were noted as present or absent: diabetes mellitus, cardiovascular disease including hypertension, severe obesity body mass index ≥40 kg/m2, chronic renal disease, chronic liver disease, chronic lung disease, any immunocompromising condition, any autoimmune condition, any neurologic condition including neurodevelopmental, intellectual, physical, visual, or hearing impairment, any psychologic/psychiatric condition, and any other underlying medical condition not otherwise specified.

†† Outcomes were calculated as the proportion of persons reported to be hospitalized, admitted to an ICU, or who died among total in the demographic group. Outcome underreporting could result from outcomes that occurred but were not reported through national case surveillance or through clinical progression to severe outcomes that occurred after time of report.

Abbreviation: COVID-19 = coronavirus disease 2019. * Hospitalization status was known for 600,860 (46%). Among 184,673 hospitalized patients, the presence of underlying health conditions was known for 96,884 (53%). † Includes reported ICU admissions. § ICU admission status was known for 186,563 (14%) patients among the total case population, representing 34% of hospitalized patients. Among 29,837 patients admitted to the ICU, the status of underlying health conditions was known for 18,317 (61%). Death outcomes were known for 480,565 (36%) patients. Among 71,116 reported deaths through case surveillance, the status of underlying health conditions was known for 40,243 (57%) patients. ** Status of underlying health conditions was known for 287,320 (22%) patients. Status was classified as “known” if any of the following conditions were noted as present or absent: diabetes mellitus, cardiovascular disease including hypertension, severe obesity body mass index ≥40 kg/m2, chronic renal disease, chronic liver disease, chronic lung disease, any immunocompromising condition, any autoimmune condition, any neurologic condition including neurodevelopmental, intellectual, physical, visual, or hearing impairment, any psychologic/psychiatric condition, and any other underlying medical condition not otherwise specified. †† Outcomes were calculated as the proportion of persons reported to be hospitalized, admitted to an ICU, or who died among total in the demographic group. Outcome underreporting could result from outcomes that occurred but were not reported through national case surveillance or through clinical progression to severe outcomes that occurred after time of report.

Discussion

As of May 30, a total of 1,761,503 aggregate U.S. cases of COVID-19 and 103,700 associated deaths were reported to CDC. Although average daily reported cases and deaths are declining, 7-day moving averages of daily incidence of COVID-19 cases indicate ongoing community transmission. The COVID-19 case data summarized here are essential statistics for the pandemic response and rely on information systems developed at the local, state, and federal level over decades for communicable disease surveillance that were rapidly adapted to meet an enormous, new public health threat. CDC aggregate counts are consistent with those presented through the Johns Hopkins University (JHU) Coronavirus Resource Center, which reported a cumulative total of 1,770,165 U.S. cases and 103,776 U.S. deaths on May 30, 2020.***** Differences in aggregate counts between CDC and JHU might be attributable to differences in reporting practices to CDC and jurisdictional websites accessed by JHU. Reported cumulative incidence in the case surveillance population among persons aged ≥20 years is notably higher than that among younger persons. The lower incidence in persons aged ≤19 years could be attributable to undiagnosed milder or asymptomatic illnesses among this age group that were not reported. Incidence in persons aged ≥80 years was nearly double that in persons aged 70–79 years. Among cases with known race and ethnicity, 33% of persons were Hispanic, 22% were black, and 1.3% were AI/AN. These findings suggest that persons in these groups, who account for 18%, 13%, and 0.7% of the U.S. population, respectively, are disproportionately affected by the COVID-19 pandemic. The proportion of missing race and ethnicity data limits the conclusions that can be drawn from descriptive analyses; however, these findings are consistent with an analysis of COVID-19–Associated Hospitalization Surveillance Network (COVID-NET) data that found higher proportions of black and Hispanic persons among hospitalized COVID-19 patients than were in the overall population (). The completeness of race and ethnicity variables in case surveillance has increased from 20% to >40% from April 2 to June 2. Although reporting of race and ethnicity continues to improve, more complete data might be available in aggregate on jurisdictional websites or through sources like the COVID Tracking Project’s COVID Racial Data Tracker. The data in this report show that the prevalence of reported symptoms varied by age group but was similar among males and females. Fewer than 5% of persons were reported to be asymptomatic when symptom data were submitted. Persons without symptoms might be less likely to be tested for COVID-19 because initial guidance recommended testing of only symptomatic persons and was hospital-based. Guidance on testing has evolved throughout the response. Whereas incidence among males and females was similar overall, severe outcomes were more commonly reported among males. Prevalence of reported severe outcomes increased with age; the percentages of hospitalizations, ICU admissions, and deaths were highest among persons aged ≥70 years, regardless of underlying conditions, and lowest among those aged ≤19 years. Hospitalizations were six times higher and deaths 12 times higher among those with reported underlying conditions compared with those with none reported. These findings are consistent with previous reports that found that severe outcomes increased with age and underlying condition, and males were hospitalized at a higher rate than were females (,,). The findings in this report are subject to at least three limitations. First, case surveillance data represent a subset of the total cases of COVID-19 in the United States; not every case in the community is captured through testing and information collected might be limited if persons are unavailable or unwilling to participate in case investigations or if medical records are unavailable for data extraction. Reported cumulative incidence, although comparable across age and sex groups within the case surveillance population, are underestimates of the U.S. cumulative incidence of COVID-19. Second, reported frequencies of individual symptoms and underlying health conditions presented from case surveillance likely underestimate the true prevalence because of missing data. Finally, asymptomatic cases are not captured well in case surveillance. Asymptomatic persons are unlikely to seek testing unless they are identified through active screening (e.g., contact tracing), and, because of limitations in testing capacity and in accordance with guidance, investigation of symptomatic persons is prioritized. Increased identification and reporting of asymptomatic cases could affect patterns described in this report. Similar to earlier reports on COVID-19 case surveillance, severe outcomes were more commonly reported among persons who were older and those with underlying health conditions (). Findings in this report align with demographic and severe outcome trends identified through COVID-NET (). Findings from case surveillance are evaluated along with enhanced surveillance data and serologic survey results to provide a comprehensive picture of COVID-19 trends, and differences in proportion of cases by racial and ethnic groups should continue to be examined in enhanced surveillance to better understand populations at highest risk. Since the U.S. COVID-19 response began in January, CDC has built on existing surveillance capacity to monitor the impact of illness nationally. Collection of detailed case data is a resource-intensive public health activity, regardless of disease incidence. The high incidence of COVID-19 has highlighted limitations of traditional public health case surveillance approaches to provide real-time intelligence and supports the need for continued innovation and modernization. Despite limitations, national case surveillance of COVID-19 serves a critical role in the U.S. COVID-19 response: these data demonstrate that the COVID-19 pandemic is an ongoing public health crisis in the United States that continues to affect all populations and result in severe outcomes including death. National case surveillance findings provide important information for targeted enhanced surveillance efforts and development of interventions critical to the U.S. COVID-19 response.

What is already known about this topic?

Surveillance data reported to CDC through April 2020 indicated that COVID-19 leads to severe outcomes in older adults and those with underlying health conditions.

What is added by this report?

As of May 30, 2020, among COVID-19 cases, the most common underlying health conditions were cardiovascular disease (32%), diabetes (30%), and chronic lung disease (18%). Hospitalizations were six times higher and deaths 12 times higher among those with reported underlying conditions compared with those with none reported.

What are the implications for public health practice?

Surveillance at all levels of government, and its continued modernization, is critical for monitoring COVID-19 trends and identifying groups at risk for infection and severe outcomes. These findings highlight the continued need for community mitigation strategies, especially for vulnerable populations, to slow COVID-19 transmission.
  5 in total

1.  Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-04-10       Impact factor: 17.586

2.  SARS-CoV-2 Infection in Children.

Authors:  Xiaoxia Lu; Liqiong Zhang; Hui Du; Jingjing Zhang; Yuan Y Li; Jingyu Qu; Wenxin Zhang; Youjie Wang; Shuangshuang Bao; Ying Li; Chuansha Wu; Hongxiu Liu; Di Liu; Jianbo Shao; Xuehua Peng; Yonghong Yang; Zhisheng Liu; Yun Xiang; Furong Zhang; Rona M Silva; Kent E Pinkerton; Kunling Shen; Han Xiao; Shunqing Xu; Gary W K Wong
Journal:  N Engl J Med       Date:  2020-03-18       Impact factor: 91.245

3.  Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-04-03       Impact factor: 17.586

4.  Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020.

Authors:  Shikha Garg; Lindsay Kim; Michael Whitaker; Alissa O'Halloran; Charisse Cummings; Rachel Holstein; Mila Prill; Shua J Chai; Pam D Kirley; Nisha B Alden; Breanna Kawasaki; Kimberly Yousey-Hindes; Linda Niccolai; Evan J Anderson; Kyle P Openo; Andrew Weigel; Maya L Monroe; Patricia Ryan; Justin Henderson; Sue Kim; Kathy Como-Sabetti; Ruth Lynfield; Daniel Sosin; Salina Torres; Alison Muse; Nancy M Bennett; Laurie Billing; Melissa Sutton; Nicole West; William Schaffner; H Keipp Talbot; Clarissa Aquino; Andrea George; Alicia Budd; Lynnette Brammer; Gayle Langley; Aron J Hall; Alicia Fry
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-04-17       Impact factor: 17.586

5.  Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-03-27       Impact factor: 17.586

  5 in total
  431 in total

1.  A Pragmatic Approach to Immunity & Respiratory Viral Infections.

Authors:  Todd A Born
Journal:  Integr Med (Encinitas)       Date:  2020-10

2.  Asymptomatic SARS-CoV-2 Infections Among Persons Entering China From April 16 to October 12, 2020.

Authors:  Ruiqi Ren; Yanping Zhang; Qun Li; Jennifer M McGoogan; Zijian Feng; George F Gao; Zunyou Wu
Journal:  JAMA       Date:  2021-02-02       Impact factor: 56.272

3.  Continuous Glucose Monitoring in Critically Ill Patients With COVID-19: Results of an Emergent Pilot Study.

Authors:  Archana R Sadhu; Ivan Alexander Serrano; Jiaqiong Xu; Tariq Nisar; Jessica Lucier; Anjani R Pandya; Bhargavi Patham
Journal:  J Diabetes Sci Technol       Date:  2020-10-16

4.  Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis.

Authors:  Lukasz Szarpak; Magdalena Borkowska; Frank W Peacock; Zubaid Rafique; Aleksandra Gasecka; Jacek Smereka; Katarzyna Pytkowska; Marta Jachowicz; Lukasz Iskrzycki; Natasza Gilis-Malinowska; Milosz J Jaguszewski
Journal:  Cardiol J       Date:  2021-05-04       Impact factor: 2.737

5.  COVID-19 highlights health promotion and chronic disease prevention amid health disparities.

Authors:  Arch G Mainous; Sonia Saxena; Valery M Beau de Rochars; Donald Macceus
Journal:  Br J Gen Pract       Date:  2020-07-30       Impact factor: 5.386

6.  An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients.

Authors:  Vinay Nair; Nicholas Jandovitz; Jamie S Hirsch; Mersema Abate; Sanjaya K Satapathy; Nitzan Roth; Santiago J Miyara; Sara Guevara; Adam M Kressel; Alec Xiang; Grace Wu; Samuel D Butensky; David Lin; Stephanie Williams; Madhu C Bhaskaran; David T Majure; Elliot Grodstein; Lawrence Lau; Gayatri Nair; Ahmed E Fahmy; Aaron Winnick; Nadine Breslin; Ilan Berlinrut; Christine Molmenti; Lance B Becker; Prashant Malhotra; Pranisha Gautam-Goyal; Brian Lima; Simon Maybaum; Samit K Shah; Ryosuke Takegawa; Kei Hayashida; Koichiro Shinozaki; Lewis W Teperman; Ernesto P Molmenti
Journal:  Am J Transplant       Date:  2020-12-16       Impact factor: 8.086

7.  Multisystem Imaging Manifestations of COVID-19, Part 2: From Cardiac Complications to Pediatric Manifestations.

Authors:  Margarita V Revzin; Sarah Raza; Neil C Srivastava; Robin Warshawsky; Catherine D'Agostino; Ajay Malhotra; Anna S Bader; Ritesh D Patel; Kan Chen; Christopher Kyriakakos; John S Pellerito
Journal:  Radiographics       Date:  2020 Nov-Dec       Impact factor: 5.333

8.  BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers.

Authors:  Magali Noval Rivas; Joseph E Ebinger; Min Wu; Nancy Sun; Jonathan Braun; Kimia Sobhani; Jennifer E Van Eyk; Susan Cheng; Moshe Arditi
Journal:  J Clin Invest       Date:  2021-01-19       Impact factor: 14.808

9.  Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells.

Authors:  Ming Zheng
Journal:  Aging Dis       Date:  2021-06-01       Impact factor: 6.745

10.  "At Home, with Care": Lessons from New York City Home-based Primary Care Practices Managing COVID-19.

Authors:  Emily Franzosa; Ksenia Gorbenko; Abraham A Brody; Bruce Leff; Christine S Ritchie; Bruce Kinosian; Katherine A Ornstein; Alex D Federman
Journal:  J Am Geriatr Soc       Date:  2020-11-20       Impact factor: 5.562

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