| Literature DB >> 32555134 |
Erin K Stokes1, Laura D Zambrano1, Kayla N Anderson1, Ellyn P Marder1, Kala M Raz1, Suad El Burai Felix1, Yunfeng Tie1, Kathleen E Fullerton1.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic resulted in 5,817,385 reported cases and 362,705 deaths worldwide through May, 30, 2020,† including 1,761,503 aggregated reported cases and 103,700 deaths in the United States.§ Previous analyses during February-early April 2020 indicated that age ≥65 years and underlying health conditions were associated with a higher risk for severe outcomes, which were less common among children aged <18 years (1-3). This report describes demographic characteristics, underlying health conditions, symptoms, and outcomes among 1,320,488 laboratory-confirmed COVID-19 cases individually reported to CDC during January 22-May 30, 2020. Cumulative incidence, 403.6 cases per 100,000 persons,¶ was similar among males (401.1) and females (406.0) and highest among persons aged ≥80 years (902.0). Among 599,636 (45%) cases with known information, 33% of persons were Hispanic or Latino of any race (Hispanic), 22% were non-Hispanic black (black), and 1.3% were non-Hispanic American Indian or Alaska Native (AI/AN). Among 287,320 (22%) cases with sufficient data on underlying health conditions, the most common were cardiovascular disease (32%), diabetes (30%), and chronic lung disease (18%). Overall, 184,673 (14%) patients were hospitalized, 29,837 (2%) were admitted to an intensive care unit (ICU), and 71,116 (5%) died. Hospitalizations were six times higher among patients with a reported underlying condition (45.4%) than those without reported underlying conditions (7.6%). Deaths were 12 times higher among patients with reported underlying conditions (19.5%) compared with those without reported underlying conditions (1.6%). The COVID-19 pandemic continues to be severe, particularly in certain population groups. These preliminary findings underscore the need to build on current efforts to collect and analyze case data, especially among those with underlying health conditions. These data are used to monitor trends in COVID-19 illness, identify and respond to localized incidence increase, and inform policies and practices designed to reduce transmission in the United States.Entities:
Mesh:
Year: 2020 PMID: 32555134 PMCID: PMC7302472 DOI: 10.15585/mmwr.mm6924e2
Source DB: PubMed Journal: MMWR Morb Mortal Wkly Rep ISSN: 0149-2195 Impact factor: 17.586
FIGUREDaily number of COVID-19 cases,,, (A) and COVID-19–associated deaths** (B) reported to CDC — United States, January 22–May 30, 2020
Abbreviation: COVID-19 = coronavirus disease 2019.
* From April 14, 2020, aggregate case counts reported by CDC included deaths attributable to both confirmed and probable COVID-19 as classified by reporting jurisdictions, using the Council of State and Territorial Epidemiologists position statement Interim-ID-20-01 (https://cdn.ymaws.com/www.cste.org/resource/resmgr/2020ps/interim-20-id-01_covid-19.pdf).
† The upper quartile of the lag between onset date and reporting to CDC was 15 days.
§ The daily number of deaths reported by jurisdictions on April 14 includes 4,141 deaths newly classified as probable.
¶ Overall <1% of cases reported in aggregate to CDC were classified as probable.
** Overall 3.1% of deaths reported in aggregate to CDC were classified as occurring in persons with probable cases.
Reported laboratory-confirmed COVID-19 cases and estimated cumulative incidence,* by sex and age group — United States, January 22–May 30, 2020
| Age group (yrs) | Males | Females | Total | |||
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| No. (%) | Cumulative incidence* | No. (%) | Cumulative incidence* | No. (%) | Cumulative incidence* | |
| 0–9 | 10,743 (1.7) | 52.5 | 9,715 (1.4) | 49.7 | 20,458 (1.5) | 51.1 |
| 10–19 | 24,302 (3.8) | 113.4 | 24,943 (3.7) | 121.4 | 49,245 (3.7) | 117.3 |
| 20–29 | 85,913 (13.3) | 370.0 | 96,556 (14.3) | 434.6 | 182,469 (13.8) | 401.6 |
| 30–39 | 108,319 (16.8) | 492.8 | 106,530 (15.8) | 490.5 | 214,849 (16.3) | 491.6 |
| 40–49 | 109,745 (17.0) | 547.0 | 109,394 (16.2) | 536.2 | 219,139 (16.6) | 541.6 |
| 50–59 | 119,152 (18.4) | 568.8 | 116,622 (17.3) | 533.0 | 235,774 (17.9) | 550.5 |
| 60–69 | 93,596 (14.5) | 526.9 | 85,411 (12.7) | 434.6 | 179,007 (13.6) | 478.4 |
| 70–79 | 53,194 (8.2) | 513.7 | 52,058 (7.7) | 422.7 | 105,252 (8.0) | 464.2 |
| ≥80 | 41,394 (6.4) | 842.0 | 72,901 (10.8) | 940.0 | 114,295 (8.7) | 902.0 |
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Abbreviation: COVID-19 = coronavirus disease 2019.
* Per 100,000 population.
The analytic dataset excludes cases reported through case surveillance that were missing information on sex (n = 19,918) or age (n = 2,379).
Reported underlying health conditions* and symptoms among persons with laboratory-confirmed COVID-19, by sex and age group — United States, January 22–May 30, 2020
| Characteristic | No. (%) | |||||||||||
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| Total | Sex | Age group (yrs) | ||||||||||
| Male | Female | ≤9 | 10–19 | 20–29 | 30–39 | 40–49 | 50–59 | 60–69 | 70–79 | ≥80 | ||
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| Known underlying medical condition status* |
| 138,887 (21.5) | 148,433 (22.0) | 2,896 (14.2) | 7,123 (14.5) | 27,436 (15.0) | 33,483 (15.6) | 40,572 (18.5) | 54,717 (23.2) | 50,125 (28.0) | 34,400 (32.7) | 36,568 (32.0) |
| Any cardiovascular disease¶ |
| 47,567 (34.2) | 44,979 (30.3) | 78 (2.7) | 164 (2.3) | 1,177 (4.3) | 3,588 (10.7) | 8,198 (20.2) | 16,954 (31.0) | 21,466 (42.8) | 18,763 (54.5) | 22,158 (60.6) |
| Any chronic lung disease |
| 20,930 (15.1) | 29,218 (19.7) | 363 (12.5) | 1,285 (18) | 4,537 (16.5) | 5,110 (15.3) | 6,127 (15.1) | 8,722 (15.9) | 9,200 (18.4) | 7,436 (21.6) | 7,368 (20.1) |
| Renal disease |
| 12,144 (8.7) | 9,764 (6.6) | 21 (0.7) | 34 (0.5) | 204 (0.7) | 587 (1.8) | 1,273 (3.1) | 2,789 (5.1) | 4,764 (9.5) | 5,401 (15.7) | 6,835 (18.7) |
| Diabetes |
| 45,089 (32.5) | 41,648 (28.1) | 12 (0.4) | 225 (3.2) | 1,409 (5.1) | 4,106 (12.3) | 9,636 (23.8) | 19,589 (35.8) | 22,314 (44.5) | 16,594 (48.2) | 12,852 (35.1) |
| Liver disease |
| 2,439 (1.8) | 1,514 (1.0) | 5 (0.2) | 19 (0.3) | 132 (0.5) | 390 (1.2) | 573 (1.4) | 878 (1.6) | 1,074 (2.1) | 583 (1.7) | 299 (0.8) |
| Immunocompromised |
| 7,345 (5.3) | 7,920 (5.3) | 61 (2.1) | 146 (2.0) | 646 (2.4) | 1,253 (3.7) | 2,005 (4.9) | 3,190 (5.8) | 3,421 (6.8) | 2,486 (7.2) | 2,057 (5.6) |
| Neurologic/Neurodevelopmental disability |
| 6,193 (4.5) | 7,472 (5.0) | 41 (1.4) | 113 (1.6) | 395 (1.4) | 533 (1.6) | 734 (1.8) | 1,338 (2.4) | 2,006 (4.0) | 2,759 (8.0) | 5,746 (15.7) |
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| Known symptom status† |
| 178,223 (27.6) | 195,660 (29.0) | 5,188 (25.4) | 12,689 (25.8) | 51,464 (28.2) | 59,951 (27.9) | 62,643 (28.6) | 70,040 (29.7) | 52,178 (29.1) | 28,583 (27.2) | 31,147 (27.3) |
| Fever, cough, or shortness of breath |
| 125,768 (70.6) | 134,938 (69.0) | 3,278 (63.2) | 7,584 (59.8) | 35,072 (68.1) | 42,016 (70.1) | 45,361 (72.4) | 51,283 (73.2) | 37,701 (72.3) | 19,583 (68.5) | 18,828 (60.4) |
| Fever |
| 80,578 (45.2) | 80,493 (41.1) | 2,404 (46.3) | 4,443 (35.0) | 20,381 (39.6) | 25,887 (43.2) | 28,407 (45.3) | 32,375 (46.2) | 23,591 (45.2) | 12,190 (42.6) | 11,393 (36.6) |
| Cough |
| 89,178 (50.0) | 98,775 (50.5) | 1,912 (36.9) | 5,257 (41.4) | 26,284 (51.1) | 31,313 (52.2) | 34,031 (54.3) | 38,305 (54.7) | 27,150 (52.0) | 12,837 (44.9) | 10,864 (34.9) |
| Shortness of breath |
| 49,834 (28.0) | 56,553 (28.9) | 339 (6.5) | 2,070 (16.3) | 13,649 (26.5) | 16,851 (28.1) | 18,978 (30.3) | 21,327 (30.4) | 16,018 (30.7) | 8,971 (31.4) | 8,184 (26.3) |
| Myalgia |
| 61,922 (34.7) | 73,104 (37.4) | 537 (10.4) | 3,737 (29.5) | 21,153 (41.1) | 26,464 (44.1) | 28,064 (44.8) | 28,594 (40.8) | 17,360 (33.3) | 6,015 (21.0) | 3,102 (10.0) |
| Runny nose |
| 9,900 (5.6) | 12,810 (6.5) | 354 (6.8) | 1,025 (8.1) | 4,591 (8.9) | 4,406 (7.3) | 4,141 (6.6) | 4,100 (5.9) | 2,671 (5.1) | 923 (3.2) | 499 (1.6) |
| Sore throat |
| 31,244 (17.5) | 43,596 (22.3) | 664 (12.8) | 3,628 (28.6) | 14,493 (28.2) | 14,855 (24.8) | 14,490 (23.1) | 13,930 (19.9) | 8,192 (15.7) | 2,867 (10.0) | 1,721 (5.5) |
| Headache |
| 54,721 (30.7) | 73,839 (37.7) | 785 (15.1) | 5,315 (41.9) | 23,723 (46.1) | 26,142 (43.6) | 26,245 (41.9) | 26,057 (37.2) | 14,735 (28.2) | 4,163 (14.6) | 1,395 (4.5) |
| Nausea/Vomiting |
| 16,549 (9.3) | 26,264 (13.4) | 506 (9.8) | 1,314 (10.4) | 6,648 (12.9) | 7,661 (12.8) | 8,091 (12.9) | 8,737 (12.5) | 5,953 (11.4) | 2,380 (8.3) | 1,523 (4.9) |
| Abdominal pain |
| 11,553 (6.5) | 16,890 (8.6) | 349 (6.7) | 978 (7.7) | 4,211 (8.2) | 5,150 (8.6) | 5,531 (8.8) | 6,134 (8.8) | 3,809 (7.3) | 1,449 (5.1) | 832 (2.7) |
| Diarrhea |
| 32,093 (18.0) | 39,946 (20.4) | 704 (13.6) | 1,712 (13.5) | 9,867 (19.2) | 12,769 (21.3) | 13,958 (22.3) | 15,536 (22.2) | 10,349 (19.8) | 4,402 (15.4) | 2,742 (8.8) |
| Loss of smell or taste |
| 12,717 (7.1) | 18,474 (9.4) | 67 (1.3) | 1,257 (9.9) | 6,828 (13.3) | 6,907 (11.5) | 6,361 (10.2) | 5,828 (8.3) | 2,930 (5.6) | 775 (2.7) | 238 (0.8) |
Abbreviation: COVID-19 = coronavirus disease 2019.
* Status of underlying health conditions known for 287,320 persons. Status was classified as “known” if any of the following conditions were reported as present or absent: diabetes mellitus, cardiovascular disease (including hypertension), severe obesity (body mass index ≥40 kg/m2), chronic renal disease, chronic liver disease, chronic lung disease, immunocompromising condition, autoimmune condition, neurologic condition (including neurodevelopmental, intellectual, physical, visual, or hearing impairment), psychologic/psychiatric condition, and other underlying medical condition not otherwise specified.
† Symptom status was known for 373,883 persons. Status was classified as “known” if any of the following symptoms were reported as present or absent: fever (measured >100.4°F [38°C] or subjective), cough, shortness of breath, wheezing, difficulty breathing, chills, rigors, myalgia, rhinorrhea, sore throat, chest pain, nausea or vomiting, abdominal pain, headache, fatigue, diarrhea (≥3 loose stools in a 24-hour period), or other symptom not otherwise specified on the form.
§ Responses include data from standardized fields supplemented with data from free-text fields. Information for persons with loss of smell or taste was exclusively extracted from a free-text field; therefore, persons exhibiting this symptom were likely underreported.
¶ Includes persons with reported hypertension.
** Includes all persons with at least one of these symptoms reported.
Persons were considered to have a fever if information on either measured or subjective fever variables if “yes” was reported for either variable.
Reported hospitalizations,*, intensive care unit (ICU) admissions, and deaths among laboratory-confirmed COVID-19 patients with and without reported underlying health conditions, by sex and age — United States, January 22–May 30, 2020
| Characteristic (no.) | Outcome, no./total no. (%)†† | ||||||||
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| Reported hospitalizations*,† (including ICU) | Reported ICU admission§ | Reported deaths¶ | |||||||
| Among all patients | Among patients with reported underlying health conditions | Among patients with no reported underlying health conditions | Among all patients | Among patients with reported underlying health conditions | Among patients with no reported underlying health conditions | Among all patients | Among patients with reported underlying health conditions | Among patients with no reported underlying health conditions | |
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| Male (646,358) | 101,133/646,358 (15.6) | 49,503/96,839 (51.1) | 3,596/42,048 (8.6) | 18,394/646,358 (2.8) | 10,302/96,839 (10.6) | 864/42,048 (2.1) | 38,773/646,358 (6.0) | 21,667/96,839 (22.4) | 724/42,048 (1.7) |
| Female (674,130) | 83,540/674,130 (12.4) | 40,698/102,040 (39.9) | 3,087/46,393 (6.7) | 11,443/674,130 (1.7) | 6,672/102,040 (6.5) | 479/46,393 (1.0) | 32,343/674,130 (4.8) | 17,145/102,040 (16.8) | 707/46,393 (1.5) |
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| ≤9 (20,458) | 848/20,458 (4.1) | 138/619 (22.3) | 84/2,277 (3.7) | 141/20,458 (0.7) | 31/619 (5.0) | 16/2,277 (0.7) | 13/20,458 (0.1) | 4/619 (0.6) | 2/2,277 (0.1) |
| 10–19 (49,245) | 1,234/49,245 (2.5) | 309/2,076 (14.9) | 115/5,047 (2.3) | 216/49,245 (0.4) | 72/2,076 (3.5) | 17/5,047 (0.3) | 33/49,245 (0.1) | 16/2,076 (0.8) | 4/5,047 (0.1) |
| 20–29 (182,469) | 6,704/182,469 (3.7) | 1,559/8,906 (17.5) | 498/18,530 (2.7) | 864/182,469 (0.5) | 300/8,906 (3.4) | 56/18,530 (0.3) | 273/182,469 (0.1) | 122/8,906 (1.4) | 24/18,530 (0.1) |
| 30–39 (214,849) | 12,570/214,849 (5.9) | 3,596/14,854 (24.2) | 828/18,629 (4.4) | 1,879/214,849 (0.9) | 787/14,854 (5.3) | 135/18,629 (0.7) | 852/214,849 (0.4) | 411/14,854 (2.8) | 21/18,629 (0.1) |
| 40–49 (219,139) | 19,318/219,139 (8.8) | 7,151/24,161 (29.6) | 1,057/16,411 (6.4) | 3,316/219,139 (1.5) | 1,540/24,161 (6.4) | 208/16,411 (1.3) | 2,083/219,139 (1.0) | 1,077/24,161 (4.5) | 58/16,411 (0.4) |
| 50–59 (235,774) | 31,588/235,774 (13.4) | 14,639/40,297 (36.3) | 1,380/14,420 (9.6) | 5,986/235,774 (2.5) | 3,335/40,297 (8.3) | 296/14,420 (2.1) | 5,639/235,774 (2.4) | 3,158/40,297 (7.8) | 131/14,420 (0.9) |
| 60–69 (179,007) | 39,422/179,007 (22.0) | 21,064/42,206 (49.9) | 1,216/7,919 (15.4) | 7,403/179,007 (4.1) | 4,588/42,206 (10.9) | 291/7,919 (3.7) | 11,947/179,007 (6.7) | 7,050/42,206 (16.7) | 187/7,919 (2.4) |
| 70–79 (105,252) | 35,844/105,252 (34.1) | 20,451/31,601 (64.7) | 780/2,799 (27.9) | 5,939/105,252 (5.6) | 3,771/31,601 (11.9) | 199/2,799 (7.1) | 17,510/105,252 (16.6) | 10,008/31,601 (31.7) | 286/2,799 (10.2) |
| ≥80 (114,295) | 37,145/114,295 (32.5) | 21,294/34,159 (62.3) | 725/2,409 (30.1) | 4,093/114,295 (3.6) | 2,550/34,159 (7.5) | 125/2,409 (5.2) | 32,766/114,295 (28.7) | 16,966/34,159 (49.7) | 718/2,409 (29.8) |
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Abbreviation: COVID-19 = coronavirus disease 2019.
* Hospitalization status was known for 600,860 (46%). Among 184,673 hospitalized patients, the presence of underlying health conditions was known for 96,884 (53%).
† Includes reported ICU admissions.
§ ICU admission status was known for 186,563 (14%) patients among the total case population, representing 34% of hospitalized patients. Among 29,837 patients admitted to the ICU, the status of underlying health conditions was known for 18,317 (61%).
¶ Death outcomes were known for 480,565 (36%) patients. Among 71,116 reported deaths through case surveillance, the status of underlying health conditions was known for 40,243 (57%) patients.
** Status of underlying health conditions was known for 287,320 (22%) patients. Status was classified as “known” if any of the following conditions were noted as present or absent: diabetes mellitus, cardiovascular disease including hypertension, severe obesity body mass index ≥40 kg/m2, chronic renal disease, chronic liver disease, chronic lung disease, any immunocompromising condition, any autoimmune condition, any neurologic condition including neurodevelopmental, intellectual, physical, visual, or hearing impairment, any psychologic/psychiatric condition, and any other underlying medical condition not otherwise specified.
†† Outcomes were calculated as the proportion of persons reported to be hospitalized, admitted to an ICU, or who died among total in the demographic group. Outcome underreporting could result from outcomes that occurred but were not reported through national case surveillance or through clinical progression to severe outcomes that occurred after time of report.