| Literature DB >> 32554568 |
Nicole L Neubarth1,2, Alan J Emanuel1,2, Yin Liu3,4, Mark W Springel1,2, Annie Handler1,2, Qiyu Zhang1,2, Brendan P Lehnert1,2, Chong Guo1, Lauren L Orefice1,2, Amira Abdelaziz1,2, Michelle M DeLisle1,2, Michael Iskols1,2, Julia Rhyins1,2, Soo J Kim1,2, Stuart J Cattel1,2, Wade Regehr1, Christopher D Harvey1, Jan Drugowitsch1, David D Ginty5,2.
Abstract
Meissner corpuscles are mechanosensory end organs that densely occupy mammalian glabrous skin. We generated mice that selectively lacked Meissner corpuscles and found them to be deficient in both perceiving the gentlest detectable forces acting on glabrous skin and fine sensorimotor control. We found that Meissner corpuscles are innervated by two mechanoreceptor subtypes that exhibit distinct responses to tactile stimuli. The anatomical receptive fields of these two mechanoreceptor subtypes homotypically tile glabrous skin in a manner that is offset with respect to one another. Electron microscopic analysis of the two Meissner afferents within the corpuscle supports a model in which the extent of lamellar cell wrappings of mechanoreceptor endings determines their force sensitivity thresholds and kinetic properties.Entities:
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Year: 2020 PMID： 32554568 PMCID： PMC7354383 DOI： 10.1126/science.abb2751
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728