Literature DB >> 32554360

Eslicarbazepine for focal epilepsy and acute intermittent porphyria.

Tamara Herrera-Fortin1, Raluca Pana1, Ewa Wesolowska1, Josiane Bourré-Tessier1, Dang K Nguyen1.   

Abstract

Porphyrias are rare genetic disorders which cause a deficiency in the enzymes involved in the biosynthesis of heme. The treatment of epilepsy in patients with acute intermittent porphyria can be difficult since many anticonvulsants can increase heme synthesis and trigger porphyric attacks. We report a patient with focal epilepsy successfully treated with eslicarbazepine without exacerbation of porphyria.

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Keywords:  carbamazepine; eslicarbazepine; hepatic porphyria

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Year:  2020        PMID: 32554360     DOI: 10.1684/epd.2020.1171

Source DB:  PubMed          Journal:  Epileptic Disord        ISSN: 1294-9361            Impact factor:   1.819


  1 in total

1.  Eslicarbazepine acetate is porphyrogenic and should be used with caution in patients with the acute hepatic porphyrias.

Authors:  Christopher D Ma; Herbert L Bonkovsky
Journal:  Front Pharmacol       Date:  2022-09-06       Impact factor: 5.988

  1 in total

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