Federica Vellante1, Francesca Ferri2, Gaia Baroni2, Pierpaolo Croce2, Daniele Migliorati2, Mauro Pettoruso2, Domenico De Berardis3, Giovanni Martinotti2, Filippo Zappasodi4, Massimo Di Giannantonio4. 1. Department of Neuroscience, Imaging and Clinical Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Italy. Electronic address: federica.vellante@unich.it. 2. Department of Neuroscience, Imaging and Clinical Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Italy. 3. Department of Neuroscience, Imaging and Clinical Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Italy; Hospital "Giuseppe Mazzini", Teramo, Italy. 4. Department of Neuroscience, Imaging and Clinical Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Italy; Institute for Advanced Biomedical Technologies, "G. d'Annunzio" University of Chieti-Pescara, Italy.
Abstract
BACKGROUND: A growing number of neuroimaging studies have revealed spatial abnormalities of resting-state functional brain network activity in bipolar disorder (BD). Conversely, abnormalities of resting state temporal dynamics have been scarcely investigated so far. The aim of this study was to characterize the EEG microstates activity in BD patients with a history of manic predominant polarity. Patients were euthymic and pharmacologically stabilized. METHODS: Nineteen BD patients (mean age 34.4 ± 11.0, 7 female) and 19 healthy controls (HC; mean age 38.2 ± 9.9, 7 female) were recruited. The psychometric evaluation included the Hamilton Depression Scale (HAMD), the Young Mania Rating Scale (YMRS), the Dissociative Experience Scale (DES), and the State-Trait Anxiety Inventory (STAI). Two runs of 2 minutes of EEG activity by a 128-channel system were acquired at rest and analyzed through microstate analysis. RESULTS: We found a reduced presence of microstate B in BD patients compared to HC, since BD patients have a tendency to transit from the microstate B to the microstates C and D significantly more than HC. Furthermore, microstate B features were correlated with DES, state STAI and trait STAI scores. CONCLUSION: The reduced presence of microstate B might be associated with episodic autobiographic memory deficit, exaggerated self-focusing and states of dissociations characteristic of BD. Strong correlations of microstate B metrics and dynamics with symptoms of dissociation and anxiety across the two groups supported this interpretation.
BACKGROUND: A growing number of neuroimaging studies have revealed spatial abnormalities of resting-state functional brain network activity in bipolar disorder (BD). Conversely, abnormalities of resting state temporal dynamics have been scarcely investigated so far. The aim of this study was to characterize the EEG microstates activity in BD patients with a history of manic predominant polarity. Patients were euthymic and pharmacologically stabilized. METHODS: Nineteen BD patients (mean age 34.4 ± 11.0, 7 female) and 19 healthy controls (HC; mean age 38.2 ± 9.9, 7 female) were recruited. The psychometric evaluation included the Hamilton Depression Scale (HAMD), the Young Mania Rating Scale (YMRS), the Dissociative Experience Scale (DES), and the State-Trait Anxiety Inventory (STAI). Two runs of 2 minutes of EEG activity by a 128-channel system were acquired at rest and analyzed through microstate analysis. RESULTS: We found a reduced presence of microstate B in BD patients compared to HC, since BD patients have a tendency to transit from the microstate B to the microstates C and D significantly more than HC. Furthermore, microstate B features were correlated with DES, state STAI and trait STAI scores. CONCLUSION: The reduced presence of microstate B might be associated with episodic autobiographic memory deficit, exaggerated self-focusing and states of dissociations characteristic of BD. Strong correlations of microstate B metrics and dynamics with symptoms of dissociation and anxiety across the two groups supported this interpretation.
Authors: Romain Icick; Ingrid Melle; Bruno Etain; Margrethe Collier Høegh; Sébastien Gard; Sofie R Aminoff; Marion Leboyer; Ole A Andreassen; Raoul Belzeaux; Chantal Henry; Thomas D Bjella; Jean-Pierre Kahn; Nils Eiel Steen; Frank Bellivier; Trine Vik Lagerberg Journal: Front Psychiatry Date: 2022-05-03 Impact factor: 5.435
Authors: Salvatore Campanella; Kemal Arikan; Claudio Babiloni; Michela Balconi; Maurizio Bertollo; Viviana Betti; Luigi Bianchi; Martin Brunovsky; Carla Buttinelli; Silvia Comani; Giorgio Di Lorenzo; Daniel Dumalin; Carles Escera; Andreas Fallgatter; Derek Fisher; Giulia Maria Giordano; Bahar Guntekin; Claudio Imperatori; Ryouhei Ishii; Hendrik Kajosch; Michael Kiang; Eduardo López-Caneda; Pascal Missonnier; Armida Mucci; Sebastian Olbrich; Georges Otte; Andrea Perrottelli; Alessandra Pizzuti; Diego Pinal; Dean Salisbury; Yingying Tang; Paolo Tisei; Jijun Wang; Istvan Winkler; Jiajin Yuan; Oliver Pogarell Journal: Clin EEG Neurosci Date: 2020-09-25 Impact factor: 1.843