Literature DB >> 32553177

Genetics Meets Epigenetics in Treg Cells and Autoimmunity.

Paula A Agudelo Garcia1, Shelley L Berger2.   

Abstract

Most autoimmunity-associated SNPs in the genome map to noncoding regulatory regions in T cells, but the nature of underlying epigenetic mechanisms and any normal purpose in T cell differentiation remain unclear. In this issue of Immunity, Ohkura et al. establish that crucial SNPs linked to autoimmune disease are enriched in DNA regions of CpG demethylation that govern Treg cell development and function.
Copyright © 2020. Published by Elsevier Inc.

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Mesh：

Year:  2020        PMID： 32553177      PMCID： PMC7751621          DOI： 10.1016/j.immuni.2020.05.009

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  7 in total

1.  Control of regulatory T cell development by the transcription factor Foxp3.

Authors:  Shohei Hori; Takashi Nomura; Shimon Sakaguchi
Journal:  Science       Date:  2003-01-09       Impact factor: 47.728

2.  Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases.

Authors:  Naganari Ohkura; Yoshiaki Yasumizu; Yohko Kitagawa; Atsushi Tanaka; Yamami Nakamura; Daisuke Motooka; Shota Nakamura; Yukinori Okada; Shimon Sakaguchi
Journal:  Immunity       Date:  2020-05-01       Impact factor: 31.745

3.  T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

Authors:  Naganari Ohkura; Masahide Hamaguchi; Hiromasa Morikawa; Kyoko Sugimura; Atsushi Tanaka; Yoshinaga Ito; Motonao Osaki; Yoshiaki Tanaka; Riu Yamashita; Naoko Nakano; Jochen Huehn; Hans Joerg Fehling; Tim Sparwasser; Kenta Nakai; Shimon Sakaguchi
Journal:  Immunity       Date:  2012-11-01       Impact factor: 31.745

4.  Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

Authors:  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi
Journal:  Nat Immunol       Date:  2016-12-19       Impact factor: 25.606

5.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Authors:  Jason D Fontenot; Marc A Gavin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

6.  Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Authors:  Kyle Kai-How Farh; Alexander Marson; Jiang Zhu; Markus Kleinewietfeld; William J Housley; Samantha Beik; Noam Shoresh; Holly Whitton; Russell J H Ryan; Alexander A Shishkin; Meital Hatan; Marlene J Carrasco-Alfonso; Dita Mayer; C John Luckey; Nikolaos A Patsopoulos; Philip L De Jager; Vijay K Kuchroo; Charles B Epstein; Mark J Daly; David A Hafler; Bradley E Bernstein
Journal:  Nature       Date:  2014-10-29       Impact factor: 49.962

7.  An integrated encyclopedia of DNA elements in the human genome.

Authors: 
Journal:  Nature       Date:  2012-09-06       Impact factor: 49.962
  7 in total
  1 in total

Review 1.  Boosting regulatory T cell function for the treatment of autoimmune diseases - That's only half the battle!

Authors:  Janine Schlöder; Fatemeh Shahneh; Franz-Joseph Schneider; Björn Wieschendorf
Journal:  Front Immunol       Date:  2022-08-10       Impact factor: 8.786
  1 in total

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