Noha I Hussien1, Ayman M Mousa2,3, Abeer A Shoman1. 1. Department of Physiology, Faculty of Medicine, Benha University, Benha, Egypt. 2. Department of Basic Health Sciences, Collage of Applied Medical Sciences, Qassim University, Buraydah, KSA. 3. Department of Histology and Cell Biology, Faculty of Medicine, Benha University, Benha, Egypt.
Abstract
CONTEXT: Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland. OBJECTIVE: To study the role of nesfatin-1 on functions of rat's thyroid gland exposed to EMRF. MATERIALS AND METHODS: Thirty adult male rats were divided equally into 3 groups as group I, group II and group III. The experiment extended for 30 days then the plasma nesfatin-1 level, thyroid functions, and thyroid tissue oxidative stress were assessed. Also; histological and immunohistochemical study studies were done to evaluate structural and apoptotic changes of the thyroid gland. RESULTS: There was a significant decrease in plasma nesfatin-1 level and thyroid functions with an increase in oxidative stress and apoptosis. Interestingly, there was a correlation between nesfatin-1 level and markers of thyroid function, oxidative stress and apoptosis. CONCLUSION: Nesfatin-1 plays a role in thyroid dysfunctions of rats exposed to mobile phone radiation.
CONTEXT: Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland. OBJECTIVE: To study the role of nesfatin-1 on functions of rat's thyroid gland exposed to EMRF. MATERIALS AND METHODS: Thirty adult male rats were divided equally into 3 groups as group I, group II and group III. The experiment extended for 30 days then the plasma nesfatin-1 level, thyroid functions, and thyroid tissue oxidative stress were assessed. Also; histological and immunohistochemical study studies were done to evaluate structural and apoptotic changes of the thyroid gland. RESULTS: There was a significant decrease in plasma nesfatin-1 level and thyroid functions with an increase in oxidative stress and apoptosis. Interestingly, there was a correlation between nesfatin-1 level and markers of thyroid function, oxidative stress and apoptosis. CONCLUSION: Nesfatin-1 plays a role in thyroid dysfunctions of rats exposed to mobile phone radiation.
Entities:
Keywords:
Nesfatin-1; cell phone radiation; oxidative stress and apoptosis; thyroid function
Authors: Arif Khan; Masood A Khan; Fahad A Alhumaydhi; Ameen S S Alwashmi; Khaled S Allemailem; Mohammed A Alsahli; Faris A Alrumaihi; Ahmad Almatroudi; Mugahid A Mobark; Ayman Mousa Journal: J Inflamm Res Date: 2020-12-08
Authors: Ayman M Mousa; Khaled S Allemailem; Fahad A Alhumaydhi; Faris Alrumaihi; Ahmad Almatroudi; Mohammad Aljasir; Ameen S S Alwashmi; Osamah Al Rugaie; Khaled E A Soliman; Abdullah S M Aljohani; Waleed Al Abdulmonem; Ahmed A Ahmed; Arif Khan; Masood A Khan; Naif AlSuhaymi; Mahdi H Alsugoor; Wafa Abdullah Al-Megrin; Abulmaaty M Elsayed Journal: Evid Based Complement Alternat Med Date: 2022-03-17 Impact factor: 2.629