Literature DB >> 32550327

Transplant nephrectomy with peritoneal window: Georgetown University experience.

Rachel Rubinz1, Oya M Andaçoğlu2, Erik Anderson1, William Corder1, Evan Michaelson1, Jack Moore2, Matthew Cooper2, Seyed Ghasemian1,2.   

Abstract

OBJECTIVES: Transplant nephrectomy is a technically challenging procedure with high complication rates. Morbidity and mortality are mostly due to hemorrhage or infection and are reported to be 17-60% and 1-39%, respectively. The most common surgical technique for transplant nephrectomy is sub-capsular, extraperitoneal approach which may result in fluid accumulation and subsequent super-infection. We report that intraperitoneal approach, after assuring hemostasis of the transplant pedicle, allows for passive drainage, decreases hematoma formation and minimizes the subsequent infection risk in the nephrectomy bed.
MATERIAL AND METHODS: From July 2009 to July 2014 a total of 38 transplant nephrectomies were performed using the intraperitoneal window technique at Georgetown University MedStar Transplant Institute (MGTI). Data was collected retrospectively.
RESULTS: Average age at the time of transplant nephrectomy was 43.9 ± 14.3, and the majority were male (55.3%). Mean time to nephrectomy was 71.7 ± 67.4 months following transplantation. Indications for nephrectomy included pain, hematuria, fever, and recalcitrant rejection. Average operative time was 97.1 ± 28.9 minutes, average blood loss was 172.5 ± 213.6 mL. A total of 9 (24%) complications occurred. Postoperative blood transfusion was the most common complication (15.7%) followed by 2 (5.3%) re-interventions; one take back for hematoma and one percutaneous drain placement for symptomatic fluid collection. We had no infection, postoperative sepsis, ICU admissions, or mortality.
CONCLUSION: Transplant nephrectomy with peritoneal window is a technique with better results compared to the literature. An opening between the transplant cavity and the peritoneum allows for passive drainage of fluid and minimizes the risk of hematoma and abscess formation. This approach does not add significant time to the operation, furthermore it may decrease morbidity and mortality by reducing overall complications, namely hematoma formation and infection, which overall decreases rates of re-interventions and length of hospital stay.
Copyright © 2019, Turkish Surgical Society.

Entities:  

Keywords:  Nephrectomy; transperitoneal; transplant

Year:  2019        PMID: 32550327      PMCID: PMC6795220          DOI: 10.5578/turkjsurg.4122

Source DB:  PubMed          Journal:  Turk J Surg        ISSN: 2564-6850


  18 in total

1.  Death after graft loss: an important late study endpoint in kidney transplantation.

Authors:  Bruce Kaplan; Herwig-Ulf Meier-Kriesche
Journal:  Am J Transplant       Date:  2002-11       Impact factor: 8.086

2.  Indication for allograft nephrectomy after irreversible rejection: is there an ideal delay?

Authors:  C Noel; M Hazzan; M Boukelmoune; S Jaillard; F Dufossé; M X Codaccioni; F R Pruvot; G Lelièvre
Journal:  Transplant Proc       Date:  1997 Feb-Mar       Impact factor: 1.066

3.  Allograft nephrectomy--a 16-year experience.

Authors:  D K Sharma; A P Pandey; V Nath; G Gopalakrishnan
Journal:  Br J Urol       Date:  1989-08

Review 4.  Management of patients with a failed kidney transplant: Dialysis reinitiation, immunosuppression weaning, and transplantectomy.

Authors:  Phuong-Thu Pham; Matthew Everly; Arman Faravardeh; Phuong-Chi Pham
Journal:  World J Nephrol       Date:  2015-05-06

5.  The effect of a first kidney transplant on a subsequent transplant outcome: an experimental and clinical study.

Authors:  David Lair; Stéphanie Coupel; Magali Giral; Maryvonne Hourmant; Georges Karam; Claire Usal; Jean Denis Bignon; Sophie Brouard; Jean-Paul Soulillou
Journal:  Kidney Int       Date:  2005-06       Impact factor: 10.612

6.  Transplant nephrectomy: what are the surgical risks?

Authors:  Victor P Alberts; Robert C Minnee; Frederike J Bemelman; Karlijn A M I van Donselaar-van der Pant; Mirza M Idu
Journal:  Ann Transplant       Date:  2013-04-16       Impact factor: 1.530

7.  Kidney retransplantation: removal or persistence of the previous failed allograft?

Authors:  P Dinis; P Nunes; L Marconi; F Furriel; B Parada; P Moreira; A Figueiredo; C Bastos; A Roseiro; V Dias; F Rolo; F Macário; A Mota
Journal:  Transplant Proc       Date:  2014 Jul-Aug       Impact factor: 1.066

8.  Role of immediate versus delayed nephrectomy for failed renal transplants.

Authors:  L H Toledo-Pereyra; C Gordon; R Kaufmann; J I Whitten; V K Mittal
Journal:  Am Surg       Date:  1987-09       Impact factor: 0.688

9.  Transplant nephrectomy improves survival following a failed renal allograft.

Authors:  Juan Carlos Ayus; Steven G Achinger; Shuko Lee; Mohamed H Sayegh; Alan S Go
Journal:  J Am Soc Nephrol       Date:  2009-10-29       Impact factor: 10.121

10.  Nephrectomy after transplant failure: current practice and outcomes.

Authors:  O Johnston; C Rose; D Landsberg; W A Gourlay; J S Gill
Journal:  Am J Transplant       Date:  2007-08       Impact factor: 8.086

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