Literature DB >> 32550184

A Bayesian analysis for investigating the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes.

Ali Reza Soltanian1,2, Bistoon Hosseini3, Hossein Mahjub1,2, Fatemeh Bahreini4, Mohammad Ebrahim Ghaffari1.   

Abstract

PURPOSE: The purpose of this study was to evaluate the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes in Iranian population, and also to provide a way for adjusting the deviation from the Hardy-Weinberg equilibrium.
METHODS: This was a case-control study, the patients were selected from the East Azerbaijan province, Iran. In this study, 125 patients with type 2 diabetes (cases) and 125 healthy individuals (controls) were studied. Genotype and allele frequencies were determined in both groups, and the deviations from the Hardy-Weinberg equilibrium were assessed using Bayesian analysis.
RESULTS: A statistically significant association was observed between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes. In genotype assessing, data analysis showed that, TT genotype play a role in diabetes type 2 risk (P = 0.001). Subjects with TT genotype had a lower risk of diabetes compared to those with CC and CT genotypes. Also, there was no significant relationship between this polymorphism and type 2 diabetes mellitus in the absence of Hardy-Weinberg equilibrium.
CONCLUSION: Our findings show that, rs13266634 polymorphism was associated with the type 2 diabetes risk in the population of Eastern Azerbaijan province; however, the low number of TT homozygous genotypes affected the precision of the results. Also, the deviation from HWE affected the results. It is recommended to perform further studies to establish Hardy-Weinberg equilibrium. The inconsistency in the results may be due to the ignorance of this equilibrium. © Springer Nature Switzerland AG 2020.

Entities:  

Keywords:  Bayesian analysis; Disease prognosis; Hardy-Weinberg equilibrium; SLC30A8 gene; Type 2 diabetes

Year:  2020        PMID： 32550184      PMCID： PMC7270300          DOI： 10.1007/s40200-020-00514-3

Source DB:  PubMed          Journal:  J Diabetes Metab Disord        ISSN： 2251-6581


  25 in total

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Journal:  Nat Genet       Date:  2010-07       Impact factor: 38.330

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Journal:  Nat Genet       Date:  2019-02-04       Impact factor: 38.330

7.  The Essentiality of Reporting Hardy-Weinberg Equilibrium Calculations in Population-Based Genetic Association Studies.

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Journal:  Cell J       Date:  2015-07-11       Impact factor: 2.479

8.  Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study.

Authors:  Sameer D Salem; Riyadh Saif-Ali; Ikram S Ismail; Zaid Al-Hamodi; Sekaran Muniandy
Journal:  BMC Endocr Disord       Date:  2014-01-06       Impact factor: 2.763

9.  Comments on: Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran.

Authors:  Preuß Michael H; Andreas Ziegler
Journal:  Cell J       Date:  2016-01-17       Impact factor: 2.479

10.  Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

Authors:  Maggie C Y Ng; Kyong Soo Park; Bermseok Oh; Claudia H T Tam; Young Min Cho; Hyoung Doo Shin; Vincent K L Lam; Ronald C W Ma; Wing Yee So; Yoon Shin Cho; Hyung-Lae Kim; Hong Kyu Lee; Juliana C N Chan; Nam H Cho
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