Literature DB >> 32549843

Effect Of Carica Papaya Leaf Extract On Platelet Count In Chronic Immune Thrombocytopenic Purpura: A Case Series.

Katherine Hampilos1, Joshua Corn1, Wendy Hodsdon1, Peter Wagner2, Ryan Roop2, Anderes Elise2, Lynn Troy2.   

Abstract

The leaves of Carica papaya have been used to treat thrombocytopenia in Dengue fever in areas where the virus is endemic. This case series describes the use of C. papaya leaf liquid extract (CPLE) as an adjunctive therapy for four patients receiving standard-of-care treatment for chronic immune thrombocytopenic purpura (ITP). The cases presented here indicate that CPLE may prove beneficial in the management of chronic ITP for patients interested in alternative therapy before progressing to second-line treatments. A larger clinical trial is warranted to evaluate CPLE as an adjunctive therapy in chronic ITP.
Copyright © 2019 InnoVision Professional Media Inc.

Entities:  

Year:  2019        PMID: 32549843      PMCID: PMC7219447     

Source DB:  PubMed          Journal:  Integr Med (Encinitas)        ISSN: 1546-993X


  17 in total

1.  Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model.

Authors:  Sinhalagoda Lekamlage Chandi Asoka Dharmarathna; Susiji Wickramasinghe; Roshitha Nilmini Waduge; Rajapakse Peramune Veddikkarage Jayanthe Rajapakse; Senanayake Abeysinghe Mudiyanselage Kularatne
Journal:  Asian Pac J Trop Biomed       Date:  2013-09

2.  Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.

Authors:  Francesco Rodeghiero; Roberto Stasi; Terry Gernsheimer; Marc Michel; Drew Provan; Donald M Arnold; James B Bussel; Douglas B Cines; Beng H Chong; Nichola Cooper; Bertrand Godeau; Klaus Lechner; Maria Gabriella Mazzucconi; Robert McMillan; Miguel A Sanz; Paul Imbach; Victor Blanchette; Thomas Kühne; Marco Ruggeri; James N George
Journal:  Blood       Date:  2008-11-12       Impact factor: 22.113

Review 3.  The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.

Authors:  Cindy Neunert; Wendy Lim; Mark Crowther; Alan Cohen; Lawrence Solberg; Mark A Crowther
Journal:  Blood       Date:  2011-02-16       Impact factor: 22.113

Review 4.  International consensus report on the investigation and management of primary immune thrombocytopenia.

Authors:  Drew Provan; Roberto Stasi; Adrian C Newland; Victor S Blanchette; Paula Bolton-Maggs; James B Bussel; Beng H Chong; Douglas B Cines; Terry B Gernsheimer; Bertrand Godeau; John Grainger; Ian Greer; Beverley J Hunt; Paul A Imbach; Gordon Lyons; Robert McMillan; Francesco Rodeghiero; Miguel A Sanz; Michael Tarantino; Shirley Watson; Joan Young; David J Kuter
Journal:  Blood       Date:  2009-10-21       Impact factor: 22.113

5.  Dengue fever treatment with Carica papaya leaves extracts.

Authors:  Nisar Ahmad; Hina Fazal; Muhammad Ayaz; Bilal Haider Abbasi; Ijaz Mohammad; Lubna Fazal
Journal:  Asian Pac J Trop Biomed       Date:  2011-08

6.  Thrombocyte counts in mice after the administration of papaya leaf suspension.

Authors:  Kathiresan Sathasivam; Surash Ramanathan; Sharif M Mansor; Mas Rosemal M H Haris; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2009-10       Impact factor: 1.704

7.  Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells.

Authors:  Jazli Aziz; Noor Lide Abu Kassim; Noor Hayaty Abu Kasim; Nazmul Haque; Mohammad Tariqur Rahman
Journal:  BMC Complement Altern Med       Date:  2015-07-08       Impact factor: 3.659

8.  Repeated dose 28-days oral toxicity study of Carica papaya L. leaf extract in Sprague Dawley rats.

Authors:  Adlin Afzan; Noor Rain Abdullah; Siti Zaleha Halim; Badrul Amini Rashid; Raja Hazlini Raja Semail; Noordini Abdullah; Ibrahim Jantan; Hussin Muhammad; Zakiah Ismail
Journal:  Molecules       Date:  2012-04-10       Impact factor: 4.411

9.  Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever.

Authors:  Soobitha Subenthiran; Tan Chwee Choon; Kee Chee Cheong; Ravindran Thayan; Mok Boon Teck; Prem Kumar Muniandy; Adlin Afzan; Noor Rain Abdullah; Zakiah Ismail
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-11       Impact factor: 2.629

10.  Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract.

Authors:  Ching S Tham; Srikumar Chakravarthi; Nagaraja Haleagrahara; Ranjit DE Alwis
Journal:  Exp Ther Med       Date:  2012-12-05       Impact factor: 2.447

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  1 in total

Review 1.  Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions.

Authors:  X Y Lim; J S W Chan; N Japri; J C Lee; T Y C Tan
Journal:  Evid Based Complement Alternat Med       Date:  2021-05-07       Impact factor: 2.629

  1 in total

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