Successful Treatment of Peripheral Proliferative Vitreoretinopathy with Cryocoagulation During Retinal Detachment Repair - A New Surgical Technique.

PURPOSE: To evaluate the effect of extrascleral cryocoagulation for the treatment of proliferative vitreoretinopathy (PVR) during retinal detachment repair.
METHODS: Patients with a rhegmatogenous retinal detachment associated with peripheral PVR Grade C star-folds were included in this study and analysed retrospectively. In all patients, PVR star-folds were treated by extrascleral cryocoagulation.
RESULTS: A total of six patients with a rhegmatogenous retinal detachment associated with at least one peripheral PVR star-fold were included in this study. Reattachment of the retina was successfully achieved in all patients.
CONCLUSION: This novel and simple technique for the treatment of localized PVR using extrascleral cryocoagulation appears to be a safe and effective approach with favourable surgical success rates.

Introduction

Proliferative vitreoretinopathy (PVR) is a severe complication of rhegmatogenous retinal detachment (RRD), and is the most common reason for failure after surgical treatment.1–3 Several studies have confirmed the hypothesis that PVR occurs as a reparative process induced by retinal breaks and excessive inflammatory reaction.4 Clinically, early stages of PVR are characterized by an increased reflectance and a cellophane appearance of the inner retinal surface. Additionally, tortuosity of both small and larger vessels is regularly observed. The pathological hallmarks of advanced PVR include pre-retinal membrane formation, causing surface wrinkling and single or multifocal star-folds. In the final stages, multidirectional tractional forces produced by posterior and/or anterior PVR form a narrow or closed funnel of the detached retina.5

Recent published series suggest that the frequency of PVR remains largely unchanged in primary rhegmatogenous retinal detachment, with the incidence ranging from 5.1 to 11.7%.1–3 In particular, intraretinal PVR can be a surgical challenge as is it not possible to peel due to the lack of a preretinal membrane. In addition, these PVR folds are often located peripherally or mid-peripherally and are therefore not really suitable for retinectomy. In this case a major retinal resection, including healthy parts of the retina, has to be performed. On the other hand, if left untreated, this area could become the source of re-detachment.

In this retrospective study, we report the outcome of PVR star-folds treated with extrascleral cryocoagulation in patients who underwent pars plana vitrectomy (PPV) for RRD.

Patients and Methods

The study was approved by the local ethic committee EKOS (BASEC Nr. 2018–00104). Research adhered to the tenets of the Declaration of Helsinki. For each patient participating in the study informed consent was obtained.

A total of six consecutive eyes/patients with a RRD were included in this study and analysed retrospectively. The age ranged between 50 and 80 years with average age of 67.8 years. In five patients vitrectomy had to be performed because of primary RRD, whereas one patient had a re-detachment after previous vitrectomy. All patients presented with a detached macula and at least one star-fold (PVR Grade C) in the periphery. Patients’ characteristics are summarized in Table 1. Patients were reviewed in our outpatient’s clinic for a mean follow-up time of 12 months (range 6–17 months).

Table 1

Patients’ Characteristics

n	Age	Sex	Eye	Surgery	Macula Status	PVR	Tamponade
1	62	m	Right	Re-detachment	Off	Star-fold, superotemporal, midperiphery	Silicone oil
2	80	m	Left	Primary	Off	Star-fold, inferotemporal, midperiphery	Densiron
3	79	f	Left	Primary	Off	Two star-folds, inferonasal and superotemporal, midperiphery	C3F8 gas
4	60	m	Left	Primary	Off	Star-fold, superior, midperiphery	Silicone oil
5	76	m	Right	Primary	Off	Star-fold, superior, midperiphery	Silicone oil
6	50	m	Right	Primary	Off	Star-fold inferonasal	Densiron

Note: C3F8 Gas = 12% octafluoropropane.

Abbreviations: PVR, proliferative vitreoretinopathy; Densiron, high-density silicone oil.

Reattachment of the retina was successfully achieved in all patients.

Surgical Technique

All surgical procedures were performed under general anaesthesia with the Stellaris System (Bausch and Lomb, New York, USA) using three 23 gauge-valved ports. A standard core and peripheral vitrectomy was performed in all patients. Retina reattachment was achieved either by direct fluid-air exchange with drainage of subretinal fluid through the main break or by using perfluorocarbon liquid followed by fluid-air exchange. Retinopexy was performed either with transconjunctival cryocoagulation or by endolaser. At the end of surgery, 12% octafluoropropane (C3F8 gas), silicon oil or high-density silicone oil (Densiron) was applied as intraocular tamponade according to the surgeon’s choice. In general, silicone oil and Densiron were removed three months postoperatively.

PVR peeling was attempted to prove that no further epiretinal PVR-membrane is present before cryotherapy. In two patients some pre-retinal PVR could be removed. Extrascleral cryotherapy (Erbokryo AE, Erbe, Germany; Temperature at −76C) was applied on the area of intraretinal PVR until a clear white spot was visible (Figure 1). Application of cryotherapy can either be performed under heavy liquid or air.

Figure 1

Pre- (A), intra- (B) and postoperative (C) fundus photography of PVR star-fold treated with cryocoagulation.

Discussion

Surgical success rates for PVR have improved as vitrectomy techniques and instruments evolved. The introduction of ancillary techniques such as longer-acting gases and long-term vitreous substitutes like silicone oil have elevated the success rate from 35% to 40% to approximately 60–75% at 6 months postoperatively.1 Despite these advances, more than one-fourth of initially successful cases result in re-detachment due to recurrent retinal traction. One of the major causes for re-detachment is still PVR.2 Recently, efforts have been directed toward the chemical inhibition of cellular proliferation and membrane contractions in PVR.6 However, none of these agents has had a sufficient impact on the prevention of PVR and consequently have not been adopted by vitreoretinal surgeons. In conclusion, PVR still remains a surgical challenge.

Herein, we present a novel technique for the treatment of localized PVR using extrascleral cryocoagulation. In particular, intraretinal PVR is difficult to manage as no preretinal membrane exists and therefore peeling of the PVR is not possible.

Pathophysiologically, we assume that treating the intraretinal PVR with cryocoagulation results in destruction of all potential PVR–forming cells producing chorioretinal atrophy. This prevents further proliferation of PVR and reduces the risk of re-detachment caused by traction. However, one concern must be addressed, although we did not experience any re-detachment caused by PVR and despite localized atrophy, in the long term there may be significant subretinal cell migration which can subsequently produce PVR and re-detach the retina again.

However, this technique is not intended for diffuse or extensive PVR where a proper retinectomy is mandatory to achieve retinal reattachment. Furthermore, PVR peeling should be attempted to prove that no epiretinal PVR-membrane is present.

In conclusion, this technique appears to be a safe and effective approach for localized intraretinal PVR with favourable long-term surgical success rates.