OBJECTIVE: We evaluated four imaging techniques, i.e. Electroencephalography (EEG)-functional Magnetic Resonance Imaging (MRI) (EEG-fMRI), High-resolution EEG (HR-EEG), Magnetoencephalography (MEG) and 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET), for the identification of the epileptogenic zone (EZ) in 41 patients with negative MRI, candidate to neurosurgery. METHODS: For each technique, results were compared to the Stereo-EEG. Diagnostic measures were calculated with respect to the post-surgical outcome, either for all the patients (39/41, two patients excluded) and for the subgroup of patients with the EZ involving more than one lobe (20/41). RESULTS: When considered individually, each functional technique showed accuracy values ranging 54,6%-63,2%, having PET, MEG and HR-EEG higher sensitivity, and EEG-fMRI higher specificity. In patients with multilobar epileptogenic zone, functional techniques achieved the best accuracies (up to 80%) when three techniques, including EEG-fMRI, were considered together. CONCLUSIONS: The study highlights the accuracy of a combination of functional imaging techniques in the identification of EZ in MRI negative focal epilepsy. The best diagnostic yield was obtained if the combination of PET, MEG (or HR-EEG as alternative), EEG-fMRI were considered together. SIGNIFICANCE: The functional imaging techniques may improve the presurgical workup of MRI negative focal epilepsy, if epileptogenic zone involves more than one lobe.
OBJECTIVE: We evaluated four imaging techniques, i.e. Electroencephalography (EEG)-functional Magnetic Resonance Imaging (MRI) (EEG-fMRI), High-resolution EEG (HR-EEG), Magnetoencephalography (MEG) and 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET), for the identification of the epileptogenic zone (EZ) in 41 patients with negative MRI, candidate to neurosurgery. METHODS: For each technique, results were compared to the Stereo-EEG. Diagnostic measures were calculated with respect to the post-surgical outcome, either for all the patients (39/41, two patients excluded) and for the subgroup of patients with the EZ involving more than one lobe (20/41). RESULTS: When considered individually, each functional technique showed accuracy values ranging 54,6%-63,2%, having PET, MEG and HR-EEG higher sensitivity, and EEG-fMRI higher specificity. In patients with multilobar epileptogenic zone, functional techniques achieved the best accuracies (up to 80%) when three techniques, including EEG-fMRI, were considered together. CONCLUSIONS: The study highlights the accuracy of a combination of functional imaging techniques in the identification of EZ in MRI negative focal epilepsy. The best diagnostic yield was obtained if the combination of PET, MEG (or HR-EEG as alternative), EEG-fMRI were considered together. SIGNIFICANCE: The functional imaging techniques may improve the presurgical workup of MRI negative focal epilepsy, if epileptogenic zone involves more than one lobe.
Authors: Andreas Koupparis; Nicolás von Ellenrieder; Hui Ming Khoo; Natalja Zazubovits; Dang Khoa Nguyen; Jeffery A Hall; Roy W R Dudley; Francois Dubeau; Jean Gotman Journal: Neurology Date: 2021-08-16 Impact factor: 11.800
Authors: Katalin Borbély; Miklós Emri; István Kenessey; Márton Tóth; Júlia Singer; Péter Barsi; Zsolt Vajda; Endre Pál; Zoltán Tóth; Thomas Beyer; Tamás Dóczi; Gábor Bajzik; Dániel Fabó; József Janszky; Zsófia Jordán; Dániel Fajtai; Anna Kelemen; Vera Juhos; Max Wintermark; Ferenc Nagy; Mariann Moizs; Dávid Nagy; János Lückl; Imre Repa Journal: Biomedicines Date: 2022-04-20
Authors: A E Vaudano; L Mirandola; F Talami; G Giovannini; G Monti; P Riguzzi; L Volpi; R Michelucci; F Bisulli; E Pasini; P Tinuper; L Di Vito; G Gessaroli; M Malagoli; G Pavesi; F Cardinale; L Tassi; L Lemieux; S Meletti Journal: Brain Topogr Date: 2021-06-21 Impact factor: 3.020
Authors: Miao Cao; Simon J Vogrin; Andre D H Peterson; William Woods; Mark J Cook; Chris Plummer Journal: Front Neurol Date: 2022-03-29 Impact factor: 4.003