| Literature DB >> 32544754 |
Giuseppe Liberatore1, Claudia Giannotta2, Blesson Punnen Sajeev2, Emanuela Morenghi3, Fabrizia Terenghi2, Francesca Gallia2, Pietro Emiliano Doneddu2, Fiore Manganelli4, Dario Cocito5, Massimiliano Filosto6, Giovanni Antonini7, Giuseppe Cosentino8, Girolama Alessandra Marfia9, Angelo Maurizio Clerici10, Giuseppe Lauria11, Tiziana Rosso12, Guido Cavaletti13, Eduardo Nobile-Orazio14.
Abstract
For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.Entities:
Keywords: Anti-MAG polyneuropathy, chronic inflammatory demyelinating polyradiculoneuropathy; ELISA; Sensitivity; Specificity
Mesh：
Substances：
Year: 2020 PMID： 32544754 DOI： 10.1016/j.jneuroim.2020.577288
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478