| Literature DB >> 32543703 |
Alain R Thierry1, Benoit Roch2.
Abstract
We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given the rapid evolution of this disease's symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. This work allows us to propose new strategies for treating the pandemic.Entities:
Keywords: COVID19; Neutrophil; Traps; circulating DNA; pathogenesis
Mesh:
Substances:
Year: 2020 PMID: 32543703 DOI: 10.1042/CS20200531
Source DB: PubMed Journal: Clin Sci (Lond) ISSN: 0143-5221 Impact factor: 6.124