H C Zheng1, E C Xue1, X H Wang1, X Chen1, S Y Wang1, H Huang1, J Jiang1, Y Ye2, C L Huang3, Y Zhou4, W J Gao1, C Q Yu1, J Lv1, X L Wu3, X M Huang3, W H Cao1, Y S Yan2, T Wu1, L M Li1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. 2. Department of Local Disease Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China. 3. Department of Hygiene, Nanjing County Center for Disease Control and Prevention, Nanjing 363600 Fujian, China. 4. Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing 100070, China.
Abstract
OBJECTIVE: To estimate the univariate heritability of resting heart rate and common chronic disease such as hypertension, diabetes, and dyslipidemia based on extended pedigrees in Fujian Tulou area and to explore bivariate heritability to test for the genetic correlation between resting heart rate and other relative phenotypes. METHODS: The study was conducted in Tulou area of Nanjing County, Fujian Province from August 2015 to December 2017. The participants were residents with Zhang surname and their relatives from Taxia Village, Qujiang Village, and Nanou Village or residents with Chen surname and their relatives from Caoban Village, Tumei Village, and Beiling Village. The baseline survey recruited 1 563 family members from 452 extended pedigrees. The pedigree reconstruction was based on the family information registration and the genealogy booklet. Univariate and bivariate heritability was estimated using variance component models for continuous variables, and susceptibility-threshold model for binary variables. RESULTS: The pedigree reconstruction identified 1 seven-generation pedigree, 2 five-generation pedigrees, 23 four-generation pedigrees, 186 three-generation pedigrees, and 240 two-generation pedigrees. The mean age of the participants was 57.2 years and the males accounted for 39.4%. The prevalence of hypertension, diabetes, dyslipidemia in this population was 49.2%, 10.0%, and 45.2%, respectively. The univariate heritability estimation of resting heart rate, hypertension, and dyslipidemia was 0.263 (95%CI: 0.120－0.407), 0.404 (95%CI: 0.135－0.673), and 0.799 (95%CI: 0.590－1), respectively. The heritability of systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was 0.379, 0.306, 0.393, 0.452, 0.568, 0.852, and 0.387, respectively. In bivariate analysis, there were phenotypic correlations between resting heart rate with hypertension, diabetes, diastolic blood pressure, fasting glucose, and triglyceride. After taking resting heart rate into account, there were strong genetic correlations between resting heart rate with fasting glucose (genetic correlation 0.485, 95%CI: 0.120－1, P<0.05) and diabetes (genetic correlation 0.795, 95%CI: 0.181－0.788, P<0.05). CONCLUSION: Resting heart rate was a heritable trait and correlated with several common chronic diseases and related traits. There was strong genetic correlation between resting heart rate with fasting glucose and diabetes, suggesting that they may share common genetic risk factors.
OBJECTIVE: To estimate the univariate heritability of resting heart rate and common chronic disease such as hypertension, diabetes, and dyslipidemia based on extended pedigrees in Fujian Tulou area and to explore bivariate heritability to test for the genetic correlation between resting heart rate and other relative phenotypes. METHODS: The study was conducted in Tulou area of Nanjing County, Fujian Province from August 2015 to December 2017. The participants were residents with Zhang surname and their relatives from Taxia Village, Qujiang Village, and Nanou Village or residents with Chen surname and their relatives from Caoban Village, Tumei Village, and Beiling Village. The baseline survey recruited 1 563 family members from 452 extended pedigrees. The pedigree reconstruction was based on the family information registration and the genealogy booklet. Univariate and bivariate heritability was estimated using variance component models for continuous variables, and susceptibility-threshold model for binary variables. RESULTS: The pedigree reconstruction identified 1 seven-generation pedigree, 2 five-generation pedigrees, 23 four-generation pedigrees, 186 three-generation pedigrees, and 240 two-generation pedigrees. The mean age of the participants was 57.2 years and the males accounted for 39.4%. The prevalence of hypertension, diabetes, dyslipidemia in this population was 49.2%, 10.0%, and 45.2%, respectively. The univariate heritability estimation of resting heart rate, hypertension, and dyslipidemia was 0.263 (95%CI: 0.120－0.407), 0.404 (95%CI: 0.135－0.673), and 0.799 (95%CI: 0.590－1), respectively. The heritability of systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was 0.379, 0.306, 0.393, 0.452, 0.568, 0.852, and 0.387, respectively. In bivariate analysis, there were phenotypic correlations between resting heart rate with hypertension, diabetes, diastolic blood pressure, fasting glucose, and triglyceride. After taking resting heart rate into account, there were strong genetic correlations between resting heart rate with fasting glucose (genetic correlation 0.485, 95%CI: 0.120－1, P<0.05) and diabetes (genetic correlation 0.795, 95%CI: 0.181－0.788, P<0.05). CONCLUSION: Resting heart rate was a heritable trait and correlated with several common chronic diseases and related traits. There was strong genetic correlation between resting heart rate with fasting glucose and diabetes, suggesting that they may share common genetic risk factors.
Authors: Adebowale A Adeyemo; Olayemi O Omotade; Charles N Rotimi; Amy H Luke; Bamidele O Tayo; Richard S Cooper Journal: J Hypertens Date: 2002-05 Impact factor: 4.844
Authors: Tengfei Man; Harriëtte Riese; Deepali Jaju; M Loretto Muñoz; Mohammed O Hassan; Said Al-Yahyaee; Riad A Bayoumi; Anthony G Comuzzie; John S Floras; Arie M van Roon; Ilja M Nolte; Sulayma Albarwani; Harold Snieder Journal: Sci Rep Date: 2019-02-07 Impact factor: 4.996
Authors: Ilja M Nolte; M Loretto Munoz; Vinicius Tragante; Azmeraw T Amare; Rick Jansen; Ahmad Vaez; Benedikt von der Heyde; Christy L Avery; Joshua C Bis; Bram Dierckx; Jenny van Dongen; Stephanie M Gogarten; Philippe Goyette; Jussi Hernesniemi; Ville Huikari; Shih-Jen Hwang; Deepali Jaju; Kathleen F Kerr; Alexander Kluttig; Bouwe P Krijthe; Jitender Kumar; Sander W van der Laan; Leo-Pekka Lyytikäinen; Adam X Maihofer; Arpi Minassian; Peter J van der Most; Martina Müller-Nurasyid; Michel Nivard; Erika Salvi; James D Stewart; Julian F Thayer; Niek Verweij; Andrew Wong; Delilah Zabaneh; Mohammad H Zafarmand; Abdel Abdellaoui; Sulayma Albarwani; Christine Albert; Alvaro Alonso; Foram Ashar; Juha Auvinen; Tomas Axelsson; Dewleen G Baker; Paul I W de Bakker; Matteo Barcella; Riad Bayoumi; Rob J Bieringa; Dorret Boomsma; Gabrielle Boucher; Annie R Britton; Ingrid Christophersen; Andrea Dietrich; George B Ehret; Patrick T Ellinor; Markku Eskola; Janine F Felix; John S Floras; Oscar H Franco; Peter Friberg; Maaike G J Gademan; Mark A Geyer; Vilmantas Giedraitis; Catharina A Hartman; Daiane Hemerich; Albert Hofman; Jouke-Jan Hottenga; Heikki Huikuri; Nina Hutri-Kähönen; Xavier Jouven; Juhani Junttila; Markus Juonala; Antti M Kiviniemi; Jan A Kors; Meena Kumari; Tatiana Kuznetsova; Cathy C Laurie; Joop D Lefrandt; Yong Li; Yun Li; Duanping Liao; Marian C Limacher; Henry J Lin; Cecilia M Lindgren; Steven A Lubitz; Anubha Mahajan; Barbara McKnight; Henriette Meyer Zu Schwabedissen; Yuri Milaneschi; Nina Mononen; Andrew P Morris; Mike A Nalls; Gerjan Navis; Melanie Neijts; Kjell Nikus; Kari E North; Daniel T O'Connor; Johan Ormel; Siegfried Perz; Annette Peters; Bruce M Psaty; Olli T Raitakari; Victoria B Risbrough; Moritz F Sinner; David Siscovick; Johannes H Smit; Nicholas L Smith; Elsayed Z Soliman; Nona Sotoodehnia; Jan A Staessen; Phyllis K Stein; Adrienne M Stilp; Katarzyna Stolarz-Skrzypek; Konstantin Strauch; Johan Sundström; Cees A Swenne; Ann-Christine Syvänen; Jean-Claude Tardif; Kent D Taylor; Alexander Teumer; Timothy A Thornton; Lesley E Tinker; André G Uitterlinden; Jessica van Setten; Andreas Voss; Melanie Waldenberger; Kirk C Wilhelmsen; Gonneke Willemsen; Quenna Wong; Zhu-Ming Zhang; Alan B Zonderman; Daniele Cusi; Michele K Evans; Halina K Greiser; Pim van der Harst; Mohammad Hassan; Erik Ingelsson; Marjo-Riitta Järvelin; Stefan Kääb; Mika Kähönen; Mika Kivimaki; Charles Kooperberg; Diana Kuh; Terho Lehtimäki; Lars Lind; Caroline M Nievergelt; Chris J O'Donnell; Albertine J Oldehinkel; Brenda Penninx; Alexander P Reiner; Harriëtte Riese; Arie M van Roon; John D Rioux; Jerome I Rotter; Tamar Sofer; Bruno H Stricker; Henning Tiemeier; Tanja G M Vrijkotte; Folkert W Asselbergs; Bianca J J M Brundel; Susan R Heckbert; Eric A Whitsel; Marcel den Hoed; Harold Snieder; Eco J C de Geus Journal: Nat Commun Date: 2017-06-14 Impact factor: 17.694
Authors: M Loretto Muñoz; Deepali Jaju; Saroja Voruganti; Sulayma Albarwani; Afshin Aslani; Riad Bayoumi; Said Al-Yahyaee; Anthony G Comuzzie; Philip J Millar; Peter Picton; John S Floras; Ilja Nolte; Mohammed O Hassan; Harold Snieder Journal: J Hypertens Date: 2018-07 Impact factor: 4.776