| Literature DB >> 32541886 |
Steffen Jørgensen1,2,3, Isabella Worlewenut Paulsen1,2, Jakob Werner Hansen4, Dorte Tholstrup4, Christoffer Hother5, Erik Sørensen5, Mikkel Steen Petersen6, Kaspar Rene Nielsen7, Klaus Rostgaard8, Margit Anita Hørup Larsen5, Peter de Nully Brown4, Elisabeth Ralfkiær9, Keld Mikkelsen Homburg1, Henrik Hjalgrim8, Christian Erikstrup6, Henrik Ullum5, Jesper Troelsen2, Kirsten Grønbæk4, Ole Birger Pedersen10.
Abstract
MicroRNAs are small regulatory RNAs that are deregulated in a wide variety of human cancers, including different types of B-cell lymphoma. Nevertheless, the feasibility of circulating microRNA for early diagnosis of B-cell lymphoma has not been established. To address the possibility of detecting specific circulating microRNAs years before a B-cell lymphoma is diagnosed, we studied the plasma expression of microRNA first in pre-treatment samples from patients with diffuse large B-cell lymphoma and subsequently in repository samples from blood donors who later developed B-cell lymphomas. In addition, we studied the microRNA expression in the diagnostic lymphoma biopsy. The most strongly induced (miR-326) and suppressed (miR-375) plasma microRNA at diagnosis, when compared with healthy blood donors, were also substantially up- or down-regulated in plasma repository samples taken from several months to up to two years before the blood donors were diagnosed with B-cell lymphoma. Importantly, at these time points the donors had no signs of disease and felt healthy enough to donate blood. In conclusion, this first study of plasma microRNA profiles from apparently healthy individuals, taken several years before B-cell lymphoma diagnosis, suggests that plasma microRNA profiles may be predictive of lymphoma development.Entities:
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Year: 2020 PMID： 32541886 PMCID： PMC7295742 DOI： 10.1038/s41598-020-66062-1
Source DB: PubMed Journal: Sci Rep ISSN： 2045-2322 Impact factor: 4.379