Elizabeth T Jensen1, Seema S Aceves2, Peter A Bonis3, Kimberly Bray4, Wendy Book5, Mirna Chehade6, Margaret H Collins7, Evan S Dellon8, Gary W Falk9, Nirmala Gonsalves10, Sandeep K Gupta11, Ikuo Hirano10, David A Katzka12, Shay Kyle13, Denise Mack5, Ellyn Kodroff13, John Leung14, Vincent A Mukkada15, Melissa Scott16, Ally Paliana13, Kathleen Sable5, Jonathan M Spergel17, Mary Jo Strobel5, Jeffrey Krischer4, Marc E Rothenberg18, Pablo Abonia18. 1. Department of Epidemiology and Prevention, Wake Forest School of Medicine. 2. Division of Rheumatology, Allergy, and Immunology, University of California San Diego. 3. Division of Gastroenterology, Tufts University School of Medicine. 4. USF Health Informatics Institute, University of South Florida. 5. American Partnership for Eosinophilic Disorders (APFED). 6. Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai. 7. Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center. 8. Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill. 9. Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania. 10. Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University. 11. Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Illinois College of Medicine. 12. Mayo Clinic. 13. Campaign Urging Research for Eosinophilic Disease (CURED) Foundation. 14. Center for Food Related Studies, Tufts Medical Center. 15. Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine. 16. Eosinophilic Family Coalition. 17. Division of Allergy-Immunology, Department of Pediatrics, Children's Hospital of Pennsylvania, Perelman School of Medicine at University of Pennsylvania. 18. Department of Pediatrics, Cincinnati Children's Hospital Medical Center.
Abstract
OBJECTIVES: Clinical features of eosinophilic esophagitis (EoE) have been well-described in the literature, however, characterization of features experienced by patients with other eosinophilic gastrointestinal diseases (EGIDs) is lacking. Using data collected from a patient contact registry, we sought to characterize and contrast patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-EoE EGIDs, including eosinophilic gastritis, gastroenteritis and colitis, relative to EoE. METHODS: We conducted a cross-sectional study of contact registry data collected from 2015 to 2018. Statistical comparisons were made using chi-square (categorical measures) and the Mann-Whitney U test (continuous measures). Multivariable analyses were used to evaluate associations between treatment and feelings of isolation. RESULTS: Of the 715 reporting an EGID diagnosis (n = 525 EoE; n = 190 non-EoE EGID), a higher proportion of those with a non-EoE EGID reported more frequent specific and nonspecific gastrointestinal symptoms, including nausea, abdominal pain, diarrhea, constipation, and bloating (P < 0.01 for all). Participants with a non-EoE EGID were more likely to report higher frequency of fatigue, isolation, and deep muscle or joint pain (P < 0.01 for all). Specific food elimination and elemental formula treatments were associated with increased odds of more frequent (at least weekly) feelings of isolation for participants with EoE (adjusted odds rtaio [aOR]: 2.4; 95% confidence interval [CI]: 1.5--4.1 for specific food elimination and adjusted OR: 1.9; 95% CI: 1.2--3.3 for elemental formula). CONCLUSIONS: Significant differences exist in the symptoms and comorbidities experienced between those with EoE versus non-EoE EGIDs. Additional investigation is needed to elucidate the factors that may contribute to the high disease burden of these poorly understood conditions.
OBJECTIVES: Clinical features of eosinophilic esophagitis (EoE) have been well-described in the literature, however, characterization of features experienced by patients with other eosinophilic gastrointestinal diseases (EGIDs) is lacking. Using data collected from a patient contact registry, we sought to characterize and contrast patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-EoE EGIDs, including eosinophilic gastritis, gastroenteritis and colitis, relative to EoE. METHODS: We conducted a cross-sectional study of contact registry data collected from 2015 to 2018. Statistical comparisons were made using chi-square (categorical measures) and the Mann-Whitney U test (continuous measures). Multivariable analyses were used to evaluate associations between treatment and feelings of isolation. RESULTS: Of the 715 reporting an EGID diagnosis (n = 525 EoE; n = 190 non-EoE EGID), a higher proportion of those with a non-EoE EGID reported more frequent specific and nonspecific gastrointestinal symptoms, including nausea, abdominal pain, diarrhea, constipation, and bloating (P < 0.01 for all). Participants with a non-EoE EGID were more likely to report higher frequency of fatigue, isolation, and deep muscle or joint pain (P < 0.01 for all). Specific food elimination and elemental formula treatments were associated with increased odds of more frequent (at least weekly) feelings of isolation for participants with EoE (adjusted odds rtaio [aOR]: 2.4; 95% confidence interval [CI]: 1.5--4.1 for specific food elimination and adjusted OR: 1.9; 95% CI: 1.2--3.3 for elemental formula). CONCLUSIONS: Significant differences exist in the symptoms and comorbidities experienced between those with EoE versus non-EoE EGIDs. Additional investigation is needed to elucidate the factors that may contribute to the high disease burden of these poorly understood conditions.
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