Qi Jiang1, Kexin Wang1, Jiaojiao Shi1, Mingfang Li1, Minglong Chen2. 1. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 2. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: chenminglong@njmu.edu.cn.
Abstract
BACKGROUND AND AIMS: Although many observational studies have suggested that alcohol intake was associated with incident atrial fibrillation (AF), controversy remains. This study aimed to examine the causal association of alcohol intake with the risk of AF. METHODS AND RESULTS: Two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of alcohol consumption, alcohol dependence, or alcohol use disorder identification test (AUDIT) scores on AF. Summary data on single nucleotide polymorphisms (SNPs) associated with AF were obtained from a genome-wide association study (GWAS) with up to 1,030,836 participants. The fixed- and random-effect inverse-variance weighted (IVW) methods were used to calculate the overall causal effects. MR analysis revealed nonsignificant association of genetically predicted alcohol consumption with risk of AF using fixed- and random-effect IVW approaches (odds ratio (OR) [95% confidence interval (CI)] = 1.004 [0.796-1.266], P = 0.975; OR [95% CI] = 1.004 [0.766-1.315], P = 0.979). Genetically predicted alcohol dependence was also not causally associated with AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 1.012 [0.978-1.048], P = 0.490; OR [95% CI] = 1.012 [0.991-1.034], P = 0.260). There was no significantly causal association between AUDIT and AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 0.889 [0.433-1.822], P = 0.748; OR [95% CI] = 0.889 [0.309-2.555], P = 0.827). Sensitivity analyses indicated no evidence of pleiotropy and heterogeneity in statistical models. CONCLUSIONS: This MR study did not find evidence of a causal association between alcohol intake and AF.
BACKGROUND AND AIMS: Although many observational studies have suggested that alcohol intake was associated with incident atrial fibrillation (AF), controversy remains. This study aimed to examine the causal association of alcohol intake with the risk of AF. METHODS AND RESULTS: Two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of alcohol consumption, alcohol dependence, or alcohol use disorder identification test (AUDIT) scores on AF. Summary data on single nucleotide polymorphisms (SNPs) associated with AF were obtained from a genome-wide association study (GWAS) with up to 1,030,836 participants. The fixed- and random-effect inverse-variance weighted (IVW) methods were used to calculate the overall causal effects. MR analysis revealed nonsignificant association of genetically predicted alcohol consumption with risk of AF using fixed- and random-effect IVW approaches (odds ratio (OR) [95% confidence interval (CI)] = 1.004 [0.796-1.266], P = 0.975; OR [95% CI] = 1.004 [0.766-1.315], P = 0.979). Genetically predicted alcohol dependence was also not causally associated with AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 1.012 [0.978-1.048], P = 0.490; OR [95% CI] = 1.012 [0.991-1.034], P = 0.260). There was no significantly causal association between AUDIT and AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 0.889 [0.433-1.822], P = 0.748; OR [95% CI] = 0.889 [0.309-2.555], P = 0.827). Sensitivity analyses indicated no evidence of pleiotropy and heterogeneity in statistical models. CONCLUSIONS: This MR study did not find evidence of a causal association between alcohol intake and AF.
Authors: Inge A T van de Luitgaarden; Sabine van Oort; Emma J Bouman; Linda J Schoonmade; Ilse C Schrieks; Diederick E Grobbee; Yvonne T van der Schouw; Susanna C Larsson; Stephen Burgess; Adriana J van Ballegooijen; N Charlotte Onland-Moret; Joline W J Beulens Journal: Eur J Epidemiol Date: 2021-08-22 Impact factor: 12.434