Aamal Sattar Taha1,2, Zohreh Zahraei1, Hussein Kadhem Al-Hakeim3. 1. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan , Kashan, Islamic Republic of Iran. 2. A Chemist in the Department of Laboratories, Ministry of Health , Wasit, Iraq. 3. Department of Chemistry, College of Science, University of Kufa , Kufa, Iraq.
Abstract
OBJECTIVE: This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS: Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS: The PE group had significantly lower apelin and higher galectin-3 levels than the control group. PE group exhibited dyslipidemia and had higher β-cell functions than the controls. Galectin-3 level correlates with insulin, glucose, and IR. High galectin-3 also is correlated positively with dyslipidemia. CONCLUSION: In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia.
OBJECTIVE: This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS: Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS: The PE group had significantly lower apelin and higher galectin-3 levels than the control group. PE group exhibited dyslipidemia and had higher β-cell functions than the controls. Galectin-3 level correlates with insulin, glucose, and IR. High galectin-3 also is correlated positively with dyslipidemia. CONCLUSION: In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia.
Authors: Aleksandra Kuzan; Emilia Królewicz; Irena Kustrzeba-Wójcicka; Karolina Lindner-Pawłowicz; Małgorzata Sobieszczańska Journal: Int J Environ Res Public Health Date: 2022-06-20 Impact factor: 4.614