Fei Han1, Fei-Fei Zhai1, Ming-Li Li2, Li-Xin Zhou1, Jun Ni1, Ming Yao1, Zheng-Yu Jin2, Li-Ying Cui1, Shu-Yang Zhang3, Yi-Cheng Zhu1. 1. Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science. 2. Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science. 3. Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science.
Abstract
AIMS: The relationship between central arterial stiffness and aging-related intracranial arteriopathy is not well investigated in the general population. In a population-based study, we investigated arterial stiffness in relation to intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia. METHODS: This study was a cross-sectional analysis on 1,123 subjects (aged 56.0±9.3 years, 37.9% men) of the population-based Shunyi study in China. Arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia were evaluated via brain magnetic resonance angiography. Multivariate regression models were constructed to investigate the association between baPWV and intracranial large artery diseases. RESULTS: Increased baPWV was significantly associated with higher prevalence of intracranial atherosclerotic stenosis (odds ratio for the highest quartile of baPWV compared with the lowest quartile, 3.66 [95% confidence interval, 1.57- 8.54]), after adjustment for cardiovascular risk factors in multivariate analysis. BaPWV was not associated with the presence of basilar artery dolichoectasia and dilation of basilar artery and internal carotid artery. When the diameters of intracranial arteries were regarded as continuous variables, increased baPWV was inversely related to the internal carotid artery diameter in fully adjusted models (β±SE, -0.083±0.042, p = 0.047). CONCLUSIONS: This population-based study demonstrates that arterial stiffness was more likely associated with intracranial stenotic arteriopathy other than intracranial dilative arteriopathy.
AIMS: The relationship between central arterial stiffness and aging-related intracranial arteriopathy is not well investigated in the general population. In a population-based study, we investigated arterial stiffness in relation to intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia. METHODS: This study was a cross-sectional analysis on 1,123 subjects (aged 56.0±9.3 years, 37.9% men) of the population-based Shunyi study in China. Arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia were evaluated via brain magnetic resonance angiography. Multivariate regression models were constructed to investigate the association between baPWV and intracranial large artery diseases. RESULTS: Increased baPWV was significantly associated with higher prevalence of intracranial atherosclerotic stenosis (odds ratio for the highest quartile of baPWV compared with the lowest quartile, 3.66 [95% confidence interval, 1.57- 8.54]), after adjustment for cardiovascular risk factors in multivariate analysis. BaPWV was not associated with the presence of basilar artery dolichoectasia and dilation of basilar artery and internal carotid artery. When the diameters of intracranial arteries were regarded as continuous variables, increased baPWV was inversely related to the internal carotid artery diameter in fully adjusted models (β±SE, -0.083±0.042, p = 0.047). CONCLUSIONS: This population-based study demonstrates that arterial stiffness was more likely associated with intracranial stenotic arteriopathy other than intracranial dilative arteriopathy.
Authors: Gary F Mitchell; Mark A van Buchem; Sigurdur Sigurdsson; John D Gotal; Maria K Jonsdottir; Ólafur Kjartansson; Melissa Garcia; Thor Aspelund; Tamara B Harris; Vilmundur Gudnason; Lenore J Launer Journal: Brain Date: 2011-11 Impact factor: 13.501
Authors: Kim Sutton-Tyrrell; Samer S Najjar; Robert M Boudreau; Lakshmi Venkitachalam; Varant Kupelian; Eleanor M Simonsick; Richard Havlik; Edward G Lakatta; Harold Spurgeon; Stephen Kritchevsky; Marco Pahor; Douglas Bauer; Anne Newman Journal: Circulation Date: 2005-06-20 Impact factor: 29.690
Authors: N M van Popele; D E Grobbee; M L Bots; R Asmar; J Topouchian; R S Reneman; A P Hoeks; D A van der Kuip ; A Hofman; J C Witteman Journal: Stroke Date: 2001-02 Impact factor: 7.914
Authors: Jose Gutierrez; Ahmet Bagci; Hannah Gardener; Tatjana Rundek; Mitchell S V Ekind; Noam Alperin; Ralph L Sacco; Clinton B Wright Journal: J Neuroimaging Date: 2013-01-14 Impact factor: 2.486