[IMPROVEMENT OF METHODS FOR THE PREVENTION AND HYGIENE OF THE ORAL MUCOSA OF STOMATHOLOGICAL PATIENTS UNDERGOING HIGH DOSAGE CHEMOTHERAPY].

Aim of the study- improving the methods of prevention and hygiene of the oral mucosa of dental patients receiving high-dose toxic chemotherapy. 55 patients aged from 30 to 65 years of oncological profile with a combined dental pathology were taken for clinical observation. Patients were divided into 2 groups according to the applied methods of oral hygiene: in group 1, a standard hygienic technique was used; group 2 additionally used the hygiene and prophylactic agent "CITO-STOP", adapted for patients undergoing high-dose chemotherapy. Measurement and comparison of the amount of methotrexate in the oral fluid in both groups was carried out according to a single scheme. The measurement was carried out by high performance liquid chromatography immediately before the introduction of methotrexate, then after the start of infusion at the following time intervals: 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 16 hours, 24 hours, 48 hours, respectively. The study of Candidaalbicans on sensitivity to the author's hygiene and prophylactic agent "CITO-STOP" was carried out in both groups. Means "CITO-STOP" has a declaration of conformity of the Eurasian Economic Union and is approved for clinical use and sale on the territory of the Russian Federation (Patent for invention No. 2607931 dated January 11, 2017). Statistical processing of the results was carried out in both groups according to a single technique. In samples of oral fluid in patients using the optional "CITO-STOP" for oral hygiene, the amount of methotrexate is significantly reduced. The effect of the drug on the Candidaalbicans culture leads to damage to the exocular matrix and subsequent lysis of the Candidaalbicans culture. The developed and tested author's remedy "CITO-STOP" is an effective tool for the prevention and oral hygiene of dental cancer patients. This tool has analgesic, epithelizing and antifungal properties. The amount of methotrexate in the oral fluid after the use of high-dose chemotherapy with the use of the hygienic prophylactic "CITO-STOP" has been proven to decrease. "CYTO-STOP" has a pronounced fungicidal activity Patients of the second group who used the "CITO-STOP" foam for additional oral hygiene and the prevention of post-cytostatic stomatitis noted an improvement in the quality of life by reducing the pain symptom, eliminating bleeding of the mucous membrane and halitosis (halitosis).