Tahir Taj1, Aslak Harbo Poulsen2, Matthias Ketzel3, Camilla Geels4, Jørgen Brandt4, Jesper Heile Christensen4, Robin Puett5, Ulla Arthur Hvidtfeldt2, Mette Sørensen6, Ole Raaschou-Nielsen7. 1. Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen Ø, Denmark. Electronic address: tahir@cancer.dk. 2. Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen Ø, Denmark. 3. Department of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research (GCARE) Department of Civil and Environmental Engineering University of Surrey, United Kingdom. 4. Department of Environmental Science, Aarhus University, Roskilde, Denmark. 5. Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen Ø, Denmark; Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, MD, USA. 6. Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen Ø, Denmark; Department of Natural Science and Environment, Roskilde University, Roskilde, Denmark. 7. Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen Ø, Denmark; Department of Environmental Science, Aarhus University, Roskilde, Denmark.
Abstract
BACKGROUND: Particulate matter (PM) air pollution is a complex mixture and the various PM constituents likely affect health differently. The literature on the relationships among specific PM constituents and the risk of cancer is sparse. In this study, we aimed to evaluate the association of PM2.5 and its constituents with the incidence of non-Hodgkin lymphoma (NHL) and the two main NHL subtypes. METHODS: We undertook a nationwide register-based case-control study including 20,847 cases registered in the Danish Cancer Registry with NHL between 1989 and 2014. Among the entire Danish population, we selected 41,749 age and sex-matched controls randomly from the Civil Registration System. We assessed modelled outdoor PM concentrations at addresses of cases and controls with a state-of-the-art multi scale air pollution modelling system and used conditional logistic regression to estimate odds ratios (ORs) adjusted for individual and neighborhood level socio-demographic variables. RESULTS: The 10-year time-weighted average concentrations of PM2.5, primary carbonaceous particles (BC/OC), secondary inorganic aerosols (SIA), secondary organic aerosols (SOA) and sea salt were 17.4, 2.3, 7.8, 0.3, and 4.1 μg/m3, respectively among controls. The results showed higher risk for NHL in association with exposure to BC/OC (OR = 1.03; 95% CI: 1.00, 1.07, per interquartile range (IQR)) and SOA (OR = 1.54; 95% CI: 1.13, 2.09, per IQR). The results indicated a higher risk for follicular lymphoma in association with several PM components. Including PM2.5 (OR = 1.16; 95% CI: 0.98-1.38), BC/OC (OR = 1.05; 95% CI: 0.97-1.14), SIA (OR = 1.44; 95% CI: 0.80-1.08), SOA (OR = 4.52; 95% CI: 0.86-23.83) per IQR. CONCLUSION: This is the first study on PM constituents and the risk of NHL. The results indicated an association with primary carbonaceous and secondary organic PM. The results need replication in other settings before any firm conclusion can be reached.
BACKGROUND: Particulate matter (PM) air pollution is a complex mixture and the various PM constituents likely affect health differently. The literature on the relationships among specific PM constituents and the risk of cancer is sparse. In this study, we aimed to evaluate the association of PM2.5 and its constituents with the incidence of non-Hodgkin lymphoma (NHL) and the two main NHL subtypes. METHODS: We undertook a nationwide register-based case-control study including 20,847 cases registered in the Danish Cancer Registry with NHL between 1989 and 2014. Among the entire Danish population, we selected 41,749 age and sex-matched controls randomly from the Civil Registration System. We assessed modelled outdoor PM concentrations at addresses of cases and controls with a state-of-the-art multi scale air pollution modelling system and used conditional logistic regression to estimate odds ratios (ORs) adjusted for individual and neighborhood level socio-demographic variables. RESULTS: The 10-year time-weighted average concentrations of PM2.5, primary carbonaceous particles (BC/OC), secondary inorganic aerosols (SIA), secondary organic aerosols (SOA) and sea salt were 17.4, 2.3, 7.8, 0.3, and 4.1 μg/m3, respectively among controls. The results showed higher risk for NHL in association with exposure to BC/OC (OR = 1.03; 95% CI: 1.00, 1.07, per interquartile range (IQR)) and SOA (OR = 1.54; 95% CI: 1.13, 2.09, per IQR). The results indicated a higher risk for follicular lymphoma in association with several PM components. Including PM2.5 (OR = 1.16; 95% CI: 0.98-1.38), BC/OC (OR = 1.05; 95% CI: 0.97-1.14), SIA (OR = 1.44; 95% CI: 0.80-1.08), SOA (OR = 4.52; 95% CI: 0.86-23.83) per IQR. CONCLUSION: This is the first study on PM constituents and the risk of NHL. The results indicated an association with primary carbonaceous and secondary organic PM. The results need replication in other settings before any firm conclusion can be reached.
Authors: Ulla Arthur Hvidtfeldt; Friederike Erdmann; Stine Kjaer Urhoj; Jørgen Brandt; Camilla Geels; Matthias Ketzel; Lise M Frohn; Jesper Heile Christensen; Mette Sørensen; Ole Raaschou-Nielsen Journal: Int J Environ Res Public Health Date: 2020-12-01 Impact factor: 3.390
Authors: Michelle C Turner; Zorana J Andersen; Andrea Baccarelli; W Ryan Diver; Susan M Gapstur; C Arden Pope; Diddier Prada; Jonathan Samet; George Thurston; Aaron Cohen Journal: CA Cancer J Clin Date: 2020-08-25 Impact factor: 508.702
Authors: Miyoun Shin; Ok-Jin Kim; Seongwoo Yang; Seung-Ah Choe; Sun-Young Kim Journal: Int J Environ Res Public Health Date: 2022-03-08 Impact factor: 3.390