HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic.

Table of Contents

Need for digital health during the COVID-19 pandemic 2

Monitoring strategies during a pandemic: Here to stay 3

Therapy for COVID-19 and potential electrical effects 7

The future: Digital medicine catalyzed by the pandemic 9

References 10

Need for digital health during the COVID-19 pandemic

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), started in the city of Wuhan in late 2019. Within a few months, the disease spread toward all parts of the world and was declared a pandemic on March 11, 2020. The current health care dilemma worldwide is how to sustain the capacity for quality services not only for those suffering from COVID-19 but also for non-COVID-19 patients, all while protecting physicians, nurses, and other allied health care workers.

The pandemic poses challenges to electrophysiologists at several levels. Hospitalized COVID-19-positive patients may have preexisting arrhythmias, develop new arrhythmias, or be placed at increased arrhythmic risk from therapies for COVID-19. Cardiac arrhythmia incidence in hospitalized patients has been documented in a few published studies, with reported rates of 7.9% and 16.7% in hospitals in New York City and Wuhan, respectively, and up to 44% in patients requiring intensive care. Life-threatening arrhythmias (ventricular tachycardia [VT]/ventricular fibrillation [VF]) can occur in up to 6% of hospitalized patients with COVID-19 infection. There have also been several case reports of atrioventricular block in hospitalized patients, which is otherwise rarely described during viral illness. , Although the residual left ventricular dysfunction and arrhythmic risk are currently unknown, preliminary pathophysiological, histological, and imaging data suggest that SARS-CoV-2 infection holds the potential to induce durable myocardial changes predisposing to arrhythmias or heart failure.

Electrocardiographic monitoring and inpatient monitoring services may become necessary but face the potential hurdles of limited telemetry wards, contamination of equipment and infection in health care personnel, and shortage of personal protective equipment. , In parallel, there is a continued responsibility to maintain care of COVID-19-negative patients with arrhythmias. These pressures have led to inventive utilization and adaptation of existing telemedicine technologies as alternative options.

This document discusses how digital health may facilitate electrophysiology practice for patients with arrhythmia, whether hospitalized for COVID-19 or not. The representation of authors from some of the most severely affected countries, such as China, Spain, Italy, and the United States, is a tribute from our worldwide community to those colleagues who have worked on the front lines of the pandemic.

Monitoring strategies during a pandemic: Here to stay

In light of the current pandemic, monitoring strategies should focus on selecting high-risk patients in need of close surveillance and using alternative remote recording devices to preserve personal protective equipment and protect health care workers from potential contagious harm.

Inpatient

For inpatient monitoring, telemetry is reasonable when there is concern for clinical deterioration (as may be indicated by acute illness, vital signs, or sinus tachycardia), or in patients with cardiovascular risk factors and/or receiving essential QT-prolonging medications. Telemetry is generally not necessary for persons under investigation without concern for arrhythmias or clinical deterioration and for those not receiving QT-prolonging drug therapy. In situations in which a hospital’s existing telemetry capacity has been exceeded by patient numbers or when conventional telemetry monitoring is not feasible, such as off-site or nontraditional hospital units, mobile devices may be used, for example, mobile cardiac outpatient telemetry (MCT), as an adjunctive approach to support inpatient care.11, 12, 13, 14, 15 The majority of MCT devices can provide continuous arrhythmia monitoring using a single-lead electrocardiogram (ECG) and allow for real-time and offline analysis of long-term ECG data. Telemetry can be extended using patch monitoring. , Smartphone ECG monitors are wireless and have also been utilized during the current pandemic. Information is limited, however, on how parameters such as QTc measured on a single- (or limited number) lead ECG can reliably substitute for 12-lead ECG information. , In 1 study, QT was underestimated by the smartphone single-lead ECG.

Outpatient

The principles of remote patient management, crossing geographic, social, and cultural barriers, can be extended to outpatient care and are important to maintain continuity of care for non-COVID-19 patients.21, 22, 23 Virtual clinics move far beyond simple telephone contacts by integrating information from photos, videos, mobile heart rhythm and mobile health devices recording ECG, and remote cardiovascular implantable electronic device (CIED) interrogations. A variety of platforms have been developed and used specifically to provide telehealth to patients via video teleconferencing , (Table 1 ). Most health care centers have expanded use of telemedicine, with some reporting 100% transformation of in-person clinic visits to telemedicine-based visits in order to maintain care for non-COVID-19 patients, thus obviating their need to come to the hospital or clinic. This supplements social distancing measures and reduces the risk of transmission, especially for the older and more vulnerable populations. It also becomes a measure to control intake into emergency rooms and outpatient facilities and to permit rapid access when necessary to subspecialists.

Table 1

Examples of commonly used platforms for telehealth25, 26, 27

	Platform	Website
HIPAA- or PHI-secure telehealth platform	accuRx∗	https://www.accurx.com
	AMD Global Telemedicine†	https://www.amdtelemedicine.com/telemedicine-products/Working-Clinic-Telemedicine.html
	American Well‡	https://business.amwell.com/solution-overview
	Attend Anywhere∗	https://www.attendanywhere.com
	BlueJeans for Healthcare‡	https://www.bluejeans.com/use-cases/healthcare
	Care Connect by KRY/LIVI§	https://www.kry.care
	Caregility‡	https://caregility.com/uhe-applications
	Cisco Webex†	https://www.webex.com/webexremotehealth.html
	ClickDoc§	https://www.cgm.com/be/index.fr.jsp
	Conexa Saúde¶	https://www.conexasaude.com.br
	Docobo∗	https://www.docobo.co.uk
	Doctena§	https://secure.doctena.com
	Doctorlink∗	https://www.doctorlink.com/video-consultation
	Doximity‡	https://www.doximity.com
	Doxy.me‡	https://doxy.me
	EMIS Health Video Consult∗	https://www.emishealth.com/products/video-consultation
	Exprivia§	https://www.exprivia.it
	FaceTalk§	https://facetalk.nl
	Google G Suite†	https://gsuite.google.com/industries/healthcare
	Helena§	https://qa.helena.care
	Intersysto§	http://www.intersysto.eu
	InTouch Health‡	https://intouchhealth.com/telehealth-solutions
	pMD‡	https://www.pmd.com/secure-messaging-telemedicine
	Microsoft Teams/Skype for Business E3 and E5†	https://www.microsoft.com/en-us/microsoft-365/microsoft-teams/healthcare-solutions
	Signal§Δ	https://signal.org
	Silicon Practice FootFall∗	https://www.siliconpractice.co.uk/video-consultations
	Spruce‡	https://www.sprucehealth.com
	TeleMedi§	https://telemedi.be
	Updox‡	https://www.updox.com
	US Department of Veterans Affairs Video Connect‡	https://www.mobile.va.gov/app/va-video-connect
	VSee‡	https://vsee.com
	Zoom for Healthcare†	https://zoom.us/healthcare
	Proprietary EMR telehealth platforms
Video-conferencing platforms (not HIPAA- or PHI-secure)	GoToMeeting
	Skype
	Zoom
Non-public-facing mobile communication platforms (not HIPAA- or PHI-secure)	Apple FaceTime
	Google Duo
	Google Hangouts
	WhatsApp

EMR = electronic medical record; HIPAA = Health Insurance Portability and Accountability Act; PHI = protected health information.

United Kingdom.

Global.

United States.

Europe.

South America—Brazil.

Encrypted, but not specifically a telehealth platform.

Electrophysiology is well placed for virtual consultations. All preobtained data, including ECGs, ambulatory ECG monitoring, cardiac imaging, and coronary angiography can be adequately reviewed electronically. Digital tools such as direct-to-consumer mobile ECG (Table 2 ) and wireless blood pressure devices can be used to further complement the telehealth visit without in-person contact. CIED, wearable/mobile health, and clinical data can be integrated into the clinician workflow.

Table 2

Examples of remote ECG and heart rate monitoring devices

	Device	Type	CE mark	FDA clearance	Additional features/notes	Website
Handheld devices	AliveCor KardiaMobile	Wireless	Yes	Yes	FDA cleared for AF (1-lead) and for QTc (6L) for COVID-19 patients on HCQ ± AZM	https://www.alivecor.com/kardiamobile
	Beurer ME 90	Wireless1-lead ECG	Yes	No		https://www.beurer.com/web/gb/products/medical/ecg-and-pulse-oximeter/mobile-ecg-device/me-90-bluetooth.php
	Cardiac Designs ECG Check	Wireless1-lead ECG	Yes	Yes		https://www.cardiacdesigns.com
	CardioComm Solutions HeartCheck CardiBeat and ECG Pen	Wireless1-lead ECG	Yes	Yes		https://www.theheartcheck.com
	COALA	Wireless1-lead ECG	Yes	Yes	Remote lung auscultation	https://www.coalalife.com
	Eko DUO	Wireless1-lead ECG	Yes	Yes	Remote cardiac auscultation/ phonocardiogram	https://www.ekohealth.com
	Omron Blood Pressure + EKG Monitor	Wireless1-lead ECG + BP cuff	No	Yes	United States and Canada only	https://omronhealthcare.com
	EKGraph	Wireless1-lead ECG	No	Yes	United States	https://sonohealth.org
Mobile cardiac telemetry devices	QardioQardioCore	Chest strap1-lead ECG	Yes	No	ECG, HR, HRV, RR, activity	https://www.getqardio.com/qardiocore-wearable-ecg-ekg-monitor-iphone
	BardyDx CAM	Patch1-lead ECG	Yes	Yes	Under clinical investigation for QTc monitoring in COVID-19 patients	https://www.bardydx.com
	BioTel Heart	Patch1-lead ECG	Yes—only for extended Holter	Yes	FDA cleared for QTc monitoring	https://www.myheartmonitor.com/device/mcot-patch
	BodyGuardian MINI Family/BodyGuardian MINI PLUS	WirelessPatch: 1-lead ECG/Wired3-lead ECG	Yes	Yes	ECG, HR, HRV, RR	https://www.preventicesolutions.com/hcp/body-guardian-mini-family
	iRhythm Zio patch/Zio AT	Patch1-lead ECG	Yes	Yes		https://www.irhythmtech.com
	InfoBionic MoMe Kardia	Wired3-lead ECG	Yes	Yes	Remote lung auscultation	https://infobionic.com
	MediBioSenseMBS HealthStream, VitalPatch, MCT	Patch1-lead ECG	Yes	Yes	Monitors up to 8 vital signs	https://www.medibiosense.com
	MEMO Patch	Patch/watch1-lead ECG	No	No	Asia; Korea FDA approved	https://www.huinno.com
	MediLynx PocketECG	Wired3-lead ECG	Yes	Yes	HRV	https://www.pocketecg.com
	RhythMedix RhythmStar	Wired3-lead ECG	No	Yes		https://www.rhythmedix.com
	Samsung S-patch Cardio	Patch1-lead ECG	Yes	No	Asia; Korea FDA approved	https://www.samsungsds.com/global/en/solutions/off/cardio/cardio.html
Smartwatches	Apple Watch	1-lead ECG	Yes	Yes	FDA cleared for AF notification	https://www.apple.com/watch
	Withings Move ECG	1-lead ECG	Yes	No	Requires Health Mate app for ECG analysis/AF detection	https://www.withings.com/us/en/move-ecg

AF = atrial fibrillation; AZM = azithromycin; BP = blood pressure; COVID-19 = coronavirus disease 2019; ECG = electrocardiogram; FDA = Food & Drug Administration; HCQ = hydroxychloroquine; HR = heart rate; HRV = heart rate variability; RR = respiratory rate.

Additional diagnostic information might be obtained without in-person contact using home enrollment of prescribed ambulatory rhythm monitors. Patch monitors can be mailed to patient homes and easily self-affixed, unlike Holter monitors with cables and electrodes requiring placement by health care workers. In some cases, new or follow-up telehealth visits will require an adjunctive in-person visit to perform a 12-lead ECG, ECG stress test, echocardiogram, or other diagnostic procedures. Occasionally, conventional clinic visits are required to accurately assess the impact of comorbidities or frailty on procedural risk, or to allow comfortable discussion with multiple family members when planning procedures with high risk. Telephone-only visits (ie, without video) may allow for a broader reach due to ease and ubiquitous accessibility as a communication strategy for immediate access for urgent matters.

There are many barriers to implementation, such as inadequate reimbursement, licensing/regulatory and privacy issues, lack of infrastructure, resistance to change, lack of access/poor Internet coverage, restricted financial resources, and limited technical skills (eg, in the elderly patient population). Some telehealth and remote ECG monitoring technologies may be simply unaffordable and/or unavailable, leading to different levels of uptake within communities and across the globe. All stakeholders should collaborate to address these challenges and promote the safe and effective use of digital health during the current pandemic. In recent months, regulations have been eased to permit consults with new patients, issuing prescriptions, and obtaining consents. In that sense, the COVID-19 pandemic may serve as an opportunity to evolve current technologies into indispensable tools for our future cardiological practice.

Therapy for COVID-19 and potential electrical effects

No specific cure exists for COVID-19.28, 29, 30 Potential COVID-19 therapies, especially hydroxychloroquine and azithromycin, are being investigated in ongoing trials but also have been used off-label in many parts of the world. These may exert QT-prolonging effects (Table 3 ) and, since recent observational data have questioned their efficacy, require a careful risk-benefit adjudication. Combination therapy (eg, hydroxychloroquine and azithromycin) may have synergistic effects on QT prolongation. , In a retrospective cohort study of 1438 COVID-19 patients hospitalized in metropolitan New York (ie, a disease epicenter), cardiac arrest was more frequent in patients who received hydroxychloroquine with azithromycin than in patients who received neither drug. The adjusted hazard ratio for in-hospital mortality for treatment with hydroxychloroquine alone was 1.08, for azithromycin alone was 0.56, and for combined hydroxychloroquine and azithromycin was 1.35. However, none of these hazard ratios were statistically significant. The observational design of this study may limit interpretation of these findings. In the absence of clear efficacy data, treatment options should be individualized taking into account their proarrhythmic potential for torsade de pointes, which may be enhanced by concomitant administration of other QT-prolonging drugs (eg, antiarrhythmics, psychotropics, etc).

Table 3

Effect on QTc and proarrhythmia of experimental pharmacological therapies for COVID-19

	QTc prolongation	TdP risk
Chloroquine37, 38, 39, 40	Moderate ↑	Low risk of TdP
Hydroxychloroquine41	Moderate ↑	Low risk of TdP
Azithromycin42, 43, 44, 45, 46, 47, 48	Moderate ↑	Very low risk of TdP
Lopinavir/ritonavir37	Moderate ↑	Low risk of TdP
Tocilizumab49	Mild ↑ or ↓	NR
Fingolimod	Mild ↑	NR
Remdesivir	NR	NR
Interferon alfacon-1	NR	NR
Ribavirin	NR	NR
Methylprednisolone	NR	NR

NR = not reported; TdP = torsade de pointes.

In COVID-19 patients receiving prior antiarrhythmic therapy, there should be a thorough consideration of risk vs benefit before initiating any QT-prolonging COVID-19 therapies, especially considering their unproven value. For instance, although some recent observational studies highlight adverse effects of hydroxychloroquine in treating this infectious disease, its use is likely to persist outside of randomized trials because of its affordability and global availability compared with, for example, remdesivir. If one of these drugs is judged to be critical, monitoring should be initiated. If life-threatening arrhythmias (VT/VF) occur, the benefit of antiarrhythmic drugs, notably amiodarone, outweighs the potential harm of hydroxychloroquine or other QT-prolonging drugs targeting COVID-19, and in these cases antiarrhythmic drugs should be prioritized and used as deemed necessary. Most importantly, all modifiable predisposing factors for QTc prolongation (electrolyte disturbances, drug-to-drug interaction) that may enhance arrhythmia susceptibility should be corrected, and the small subset of individuals with an underlying genetic predisposition such as congenital long QT syndrome (in whom QTc-prolonging medications are contraindicated) should be identified. Additionally, caution must be exercised in case of subclinical or manifest myocarditis that may increase the vulnerability to proarrhythmias associated with QT-prolonging drugs.

If drugs that exert a QT-prolonging effect are to be initiated in an inpatient setting, a baseline 12-lead ECG should be acquired. Following review of the QTc, patients can be stratified into low-risk group (QTc of <500 ms or <550 ms in the setting of wide baseline QRS) or high-risk group (baseline QTc of ≥500 ms or ≥550 ms in the setting of wide baseline QRS, or patients who are started on combination therapies), guiding selection of telemetered vs nonmonitored beds. Low-risk patients treated with QT-prolonging agents may be monitored using MCT (or another available wearable) with twice-a-day transmission of QTc measurements and any urgent alerts. High-risk patients would require more continuous monitoring and follow-up QTc measurements using telemetry preferably (but if unavailable, other remote monitoring devices). A second QTc assessment via telemetry or other remote devices after 2 doses may be helpful in identifying “QTc reactors”—patients who have an exaggerated response to QT-prolonging agents. An increase in QTc by ≥60 ms or to QTc ≥500 ms on any follow-up QT assessment is considered significant and should prompt a reassessment of risks vs benefits of continuing the drug.

In the outpatient setting, a recent statement from the US Food & Drug Administration (FDA) “cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems.” (This does not affect FDA-approved uses for malaria, lupus, and rheumatoid arthritis.) Exceptions to this practice are acknowledged to occur in some regions, as these drugs have been used outside the United States without regulatory warnings. Under these conditions, or when these drugs are maintained after hospital discharge, consumer mobile ECG devices capable of generating QTc measurements may be used. If the QTc increases significantly, physicians can consider a change or discontinuation of medication via the phone or virtual medical services.

Electrocardiographic monitoring during clinical trials

Several double- and multi-arm blind randomized controlled trials are underway worldwide for COVID-19 outpatients utilizing different medications that may prolong the QT interval.52, 53, 54, 55, 56 These drugs are being tested either alone or in various combinations and are being compared with one another, with differential dosing regimens and/or placebo. These drugs are also being tested for postexposure prophylaxis in high-risk groups.

Mobile health using smartphone-based portable ECG devices as QTc monitoring tools is an innovative and economical solution to conduct monitoring in outpatient trials. For instance, in 1 trial evaluating hydroxychloroquine and azithromycin (hydroxychloroquine alone and hydroxychloroquine/azithromycin combination) against a placebo, participants receive remote training to acquire a 6-lead ECG at baseline and then at specified follow-up intervals through the trial period (Figure 1 ). These ECGs are transmitted to a remote QTc monitoring site, where the QTc is assessed and monitored over the treatment period.

Figure 1

Electrocardiogram (ECG) acquisition and transmission using a smartphone-based portable ECG monitor.

The future: Digital medicine catalyzed by the pandemic

The COVID-19 public health emergency has forced changes to traditional norms of health care access and delivery across all continents. It has accelerated adoption of telemedicine and all aspects of digital health, regarded as a positive development. Today’s new reality will likely define medicine going forward. Many monitoring and diagnostic testing aspects of both inpatient and outpatient care will be increasingly served by digital medicine tools.

The need for contactless monitoring for inpatients triaged to intensive care unit, telemetry, or nonconventional environments, as well as for outpatients needing continued management, has triggered novel implementation of digital health monitoring tools. Some centers have created algorithms based on predictive analytics of electronic medical record (EMR) data. Centralized monitoring or mobile continuous monitoring has improved patient outcomes, reduced manpower needs, and is being utilized more commonly. The use of wearables such as watches, smartphones, and smart beds (with elimination of cables and skin electrodes) for in-hospital telemetry is a novel approach. This type of wireless monitoring may be continued after discharge, permitting prolonged surveillance of rhythm and other physiological parameters. Bracelet technologies may transmit multiple parameters (eg, heart rate, sleep, oxygen desaturation index, and blood pressure) via a smartphone link to centralized hubs. These technologies provide a solution for intensive monitoring extending beyond the hospital environment.

Outpatient management has been revolutionized since the start of the pandemic. Social distancing measures and restricted clinic access have driven the rapid adoption of telehealth mechanisms to continue management of non-COVID-19 patients. Virtual visits that have been used for decades to reach isolated communities, but less commonly utilized in advanced health systems, have now become the mainstay of ambulatory care across all subspecialties. The initial experience appears to have been positive for both patients and caregivers. Heart rhythm professionals are fortunate to have a choice of wireless technologies to relay monitored information to maintain connection. Wearable and smartphone-based devices allow convenient real-time monitoring for arrhythmias on a long-term basis due to the comfort associated with their small size and ease of use while reducing patient and health care worker exposure. Remote CIED monitoring has existed for decades. It is strongly endorsed by professional societies, but in practice only a fraction of its diagnostic and therapeutic capabilities has been utilized—until now. Since the start of the pandemic, utilization of wireless communication with CIEDs has grown exponentially, permanently altering the future of device follow-up. Patient outcomes may be improved with intensive device-based monitoring compared with traditional in-clinic evaluations at regular intervals. Recent data indicate that in-person CIED evaluation can be extended safely to at least biennially when daily digital connectivity is maintained. Remote monitoring has the potential advantage of detecting and alerting caregivers (and in the future—patients directly) about important parameter changes, enabling earlier patient hospitalization, even during a presymptomatic phase.

Connectivity permits longitudinal follow-up, with advantages ranging from individual disease management to assessment of the penetration of recommended therapies into communities. , The ability for CIED remote monitoring data to be streamed to or accessed by multiple providers can facilitate communication and cooperative treatment and should be encouraged. This will require approval by patients, regulators, and manufacturers. Lessons learned from implantable devices can be applied widely in telemedicine. Regulatory bodies have been responsive, for example, approving smartphone-based QT interval measurement and telehealth services across state lines in the United States. The pandemic experience should serve as an impetus to expedite the resolution of persistent challenges, such as validation of digital technologies, infrastructure for data management (and mechanism for relay to patients and caregivers), interoperability with EMR, application of predictive analytics, cybersecurity (and with it the capability for limited forms of remote CIED programming), and reimbursement.64, 65, 66

In summary, the crisis precipitated by the pandemic has catalyzed the adoption of remote patient management across many specialties and for heart rhythm professionals, in particular. This practice is here to stay—it will persist even if other less arrhythmogenic treatment strategies evolve for COVID-19 and after the pandemic has passed. This is an opportunity to embed and grow remote services in everyday medical practice worldwide.

Appendix 1

Author disclosure table

Writing group member	Employment	Honoraria/speaking/consulting	Speakers’ bureau	Research∗	Fellowship support∗	Ownership/partnership/principal/majority stockholder	Stock or stock options	Intellectual property/royalties	Other
Niraj Varma, MA, MD, PhD, FACC, FRCP (Chair)	Cleveland Clinic, Cleveland, Ohio	1: BIOTRONIK; 1: EP Solutions; 1: Medtronic; 1: MicroPort	None	1: Boston Scientific;2: Abbott	None	None	None	None	None
Nassir F. Marrouche, MD, FHRS (Vice-Chair)	Tulane University School of Medicine, New Orleans, Louisiana	0: Biosense Webster; 0: BIOTRONIK; 0: Cardiac Design; 0: Medtronic;1: Preventice	None	0: Abbott; 0: Boston Scientific; 0: GE Healthcare;5: Biosense Webster	None	None	None	None	None
Luis Aguinaga, MD, MBA, PhD, FESC, FACC	Centro Privado de Cardiología, Tucuman, Argentina	None	None	None	None	None	None	None	None
Christine M. Albert, MD, MPH, FHRS, FACC	Cedars-Sinai Medical Center, Los Angeles, California	1: Roche Diagnostics	None	5: Abbott; 5: NIH; 5: Roche Diagnostics	None	None	None	None	None
Elena Arbelo, MD, MSci, PhD	Arrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Institut d’Investigacións Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain	1: Biosense Webster	None	None	None	None	None	None	None
Jong-Il Choi, MD, PhD, MHS	Korea University Medical Center, Seoul, Republic of Korea	None	None	None	None	None	None	None	None
Mina K. Chung, MD, FHRS, FACC	Cleveland Clinic, Cleveland, Ohio	2: ABIM	None	5: AHA; 5: NIH	None	None	None	1: Elsevier; 1: UpToDate	0: ACC (EP Section Leadership Council member); 0: AHA (Chair, ECG & Arrhythmias Committee; Member, Clinical Cardiology Leadership Committee; Member, Committee on Scientific Sessions Programming); 0: Amarin (Data monitoring committee member); 0: BIOTRONIK (EPIC Alliance steering committee member);2: AHA (Associate Editor, Circulation: Arrhythmia and Electrophysiology)
Giulio Conte, MD, PhD	Cardiocentro, Lugano, Switzerland	None	None	5: Boston Scientific; 5: Swiss National Science Foundation	None	None	None	None	None
Lilas Dagher, MD	Tulane University School of Medicine, New Orleans, Louisiana	None	None	None	None	None	None	None	None
Laurence M. Epstein, MD, FACC	Northwell Health, North Shore University Hospital, Manhasset, New York	1: Abbott;2: Medtronic; 2: Spectranetics Corporation	None	None	None	None	None	None	2: Boston Scientific (Clinical Events Committee)
Hamid Ghanbari, MD, FACC	University of Michigan, Ann Arbor, Michigan	2: Preventice	None	1: BIOTRONIK; 1: Boston Scientific; 1: Medtronic; 1: Toyota	None	None	None	None	1: Preventice (Travel/Entertainment)
Janet K. Han, MD, FHRS, FACC	VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California	1: Abbott; 1: Medtronic	None	None	None	None	None	None	None
Hein Heidbuchel, MD, PhD, FESC, FEHRA	Antwerp University and University Hospital, Antwerp, Belgium	None	None	None	None	None	None	None	None
He Huang, MD, FACC, FESC, FEHRA	Renmin Hospital of Wuhan University, Wuhan, China	None	None	None	None	None	None	None	None
Dhanunjaya R. Lakkireddy, MD, FHRS, FACC	Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, Kansas	1: BIOTRONIK;2: Abbott	1: Abiomed; 1: Biosense Webster; 1: Boston Scientific;2: Janssen	None	None	None	None	None	None
Tachapong Ngarmukos, MD, FAPHRS, FACC	Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand	1: Abbott; 1: Bayer; 1: BiosenseWebster; 1: BIOTRONIK; 1: Boehringer Ingelheim; 1: Boston Scientific; 1: Daiichi Sankyo; 1: Medtronic; 1: Pfizer	None	None	None	None	None	None	None
Andrea M. Russo, MD, FHRS, FACC	Cooper Medical School of Rowan University, Camden, New Jersey	None	None	1: MediLynx;2: Boehringer Ingelheim; 2: Boston Scientific	None	None	None	1: UpToDate	0: ABIM (Member, ABIM Cardiovascular Board); 0: Apple Inc. (Steering Committee Apple Heart Study); 0: Boston Scientific (Steering Committee, Research)
Eduardo B. Saad, MD, PhD, FHRS, FESC	Hospital Pró-Cardíaco, Rio de Janeiro, Brazil	1: Biosense Webster	None	None	None	None	None	None	1: Abbott (Travel/Entertainment)
Luis C. Saenz Morales, MD	CardioInfantil Foundation, Cardiac Institute, Bogota, Colombia	None	None	None	None	None	None	None	None
Kristin E. Sandau, PhD, RN	Bethel University, St. Paul, Minnesota	1: Japanese Association of Cardiovascular Nursing	None	None	None	None	None	None	1: Patient Safety Authority
Arun Raghav M. Sridhar, MD, MPH, FACC	University of Washington, Seattle, Washington	None	None	None	None	None	None	None	None
Eric C. Stecker, MD, MPH, FACC	Oregon Health & Science University, Portland, Oregon	None	None	4: AHA	None	None	None	None	None
Paul D. Varosy, MD, FHRS, FACC	VA Eastern Colorado Health Care System and University of Colorado, Aurora, Colorado	None	None	4: NIH	None	None	None	None	0: ACC (Committee Chair); 0: AHA (Committee Member); 0: NCDR (Committee Chair/Member)

Number value: 0 = $0; 1 = ≤$10,000; 2 = >$10,000 to ≤$25,000; 3 = >$25,000 to ≤$50,000; 4 = >$50,000 to ≤$100,000; 5 = >$100,000.

ABIM = American Board of Internal Medicine; ACC = American College of Cardiology; AHA = American Heart Association; NCDR = National Cardiovascular Data Registry; NIH = National Institutes of Health.

Research and fellowship support are classed as programmatic support. Sources of programmatic support are disclosed but are not regarded as a relevant relationship with industry for writing group members or reviewers.