Yang Chun Chen1,2, Qing Qing Wang3, Yue Hui Wang3, Hui Lin Zhuo4, Ruo Zhu Dai4. 1. Department of Nuclear Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China. fudanzhsh@ymail.com. 2. Medical College, Huaqiao University, South Anji Road 1028#, Fengze District, Quanzhou, 362000, China. fudanzhsh@ymail.com. 3. Department of Nuclear Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China. 4. Department of Cardiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, China.
Abstract
BACKGROUND: An open-label, single-center, randomized controlled prospective trial was performed to assess the efficiency and safety of an insulin loading procedure to obtain high-quality cardiac 18F-FDG PET/CT images for patients with coronary artery disease (CAD). METHODS: Between November 22, 2018 and August 15, 2019, 60 patients with CAD scheduled for cardiac 18F-FDG PET/CT imaging in our department were randomly allocated in a 1:1 ratio to receive an insulin or standardized glucose loading procedure for cardiac 18F-FDG imaging. The primary outcome was the ratio of interpretable images (high-quality images defined as myocardium-to-liver ratios ≥ 1). The secondary outcome was the patient preparation time (time interval between administration of insulin/glucose and 18F-FDG injection). Hypoglycemia events were recorded. RESULTS: The ratio of interpretable cardiac PET images in the insulin loading group surpassed the glucose loading group (30/30 vs. 25/30, P = 0.026). Preparation time was 71±2 min shorter for the insulin loading group than for the glucose loading group (P < 0.01). Two and six hypoglycemia cases occurred in the insulin and glucose loading groups, respectively. CONCLUSION: The insulin loading protocol was a quicker, more efficient, and safer preparation for gaining high-quality cardiac 18F-FDG images.
BACKGROUND: An open-label, single-center, randomized controlled prospective trial was performed to assess the efficiency and safety of an insulin loading procedure to obtain high-quality cardiac 18F-FDG PET/CT images for patients with coronary artery disease (CAD). METHODS: Between November 22, 2018 and August 15, 2019, 60 patients with CAD scheduled for cardiac 18F-FDG PET/CT imaging in our department were randomly allocated in a 1:1 ratio to receive an insulin or standardized glucose loading procedure for cardiac 18F-FDG imaging. The primary outcome was the ratio of interpretable images (high-quality images defined as myocardium-to-liver ratios ≥ 1). The secondary outcome was the patient preparation time (time interval between administration of insulin/glucose and 18F-FDG injection). Hypoglycemia events were recorded. RESULTS: The ratio of interpretable cardiac PET images in the insulin loading group surpassed the glucose loading group (30/30 vs. 25/30, P = 0.026). Preparation time was 71±2 min shorter for the insulin loading group than for the glucose loading group (P < 0.01). Two and six hypoglycemia cases occurred in the insulin and glucose loading groups, respectively. CONCLUSION: The insulin loading protocol was a quicker, more efficient, and safer preparation for gaining high-quality cardiac 18F-FDG images.
Authors: Arend F L Schinkel; Jeroen J Bax; Roelf Valkema; Abdou Elhendy; Ron T van Domburg; Eleni C Vourvouri; Manolis A Bountioukos; Eric P Krenning; Jos R T C Roelandt; Don Poldermans Journal: J Nucl Med Date: 2003-06 Impact factor: 10.057
Authors: Susanne Markendorf; Dominik C Benz; Michael Messerli; Marvin Grossmann; Andreas A Giannopoulos; Dimitri Patriki; Tobias A Fuchs; Christoph Gräni; Aju P Pazhenkottil; Ronny R Buechel; Philipp A Kaufmann; Oliver Gaemperli Journal: J Nucl Cardiol Date: 2019-08-09 Impact factor: 5.952