Marco Mascitti1, Angela Tempesta2, Lucrezia Togni1, Saverio Capodiferro2, Giuseppe Troiano3, Corrado Rubini4, Eugenio Maiorano5, Andrea Santarelli1,6, Gianfranco Favia2, Luisa Limongelli2. 1. Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy. 2. Interdisciplinary Department of Medicine, Section of Odontostomatology, University of Bari Aldo Moro, Bari, Italy. 3. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. 4. Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy. 5. Department of Emergency and Organ Transplantation, Section of Pathological Anatomy, University of Bari Aldo Moro, Bari, Italy. 6. Dentistry Clinic, National Institute of Health and Science of Aging, IRCCS INRCA, Ancona, Italy.
Abstract
OBJECTIVES: The frequency of oral squamous cell carcinoma in young adults has increased in the last decades, and there are conflicting results in literature about its prognosis in young subjects. The aim of this study was to analyse the clinical and pathological features of oral squamous cell carcinoma in a cohort of young adults in order to investigate the presence of new independent prognostic markers. MATERIALS AND METHODS: Only HPV-negative young patients (under 40-year-old) affected by oral squamous cell carcinoma were considered in this study. Clinical and pathological data were collected. Patients were re-staged according to the 8th edition of AJCC. RESULTS: Overall, 66 patients were considered in this study. Perineural invasion significant correlated with both 7th and 8th edition of AJCC, and lymphovascular invasion (p-value < .05). The multivariate survival analysis showed that patients with perineural invasion had a significant worse prognosis (HR = 6.384 95% C.I. 1.304-31.252; p-value = .022). CONCLUSIONS: Perineural invasion emerged as an independent prognostic factor for disease-specific survival in young patients with oral squamous cell carcinoma. Furthermore, the evaluation of this parameter is simple, inexpensive and can be used to augment the risk stratification of oral cancer based on the 8th edition of AJCC.
OBJECTIVES: The frequency of oral squamous cell carcinoma in young adults has increased in the last decades, and there are conflicting results in literature about its prognosis in young subjects. The aim of this study was to analyse the clinical and pathological features of oral squamous cell carcinoma in a cohort of young adults in order to investigate the presence of new independent prognostic markers. MATERIALS AND METHODS: Only HPV-negative young patients (under 40-year-old) affected by oral squamous cell carcinoma were considered in this study. Clinical and pathological data were collected. Patients were re-staged according to the 8th edition of AJCC. RESULTS: Overall, 66 patients were considered in this study. Perineural invasion significant correlated with both 7th and 8th edition of AJCC, and lymphovascular invasion (p-value < .05). The multivariate survival analysis showed that patients with perineural invasion had a significant worse prognosis (HR = 6.384 95% C.I. 1.304-31.252; p-value = .022). CONCLUSIONS: Perineural invasion emerged as an independent prognostic factor for disease-specific survival in young patients with oral squamous cell carcinoma. Furthermore, the evaluation of this parameter is simple, inexpensive and can be used to augment the risk stratification of oral cancer based on the 8th edition of AJCC.
Authors: Eder da Silva Dolens; Mauricio Rocha Dourado; Alhadi Almangush; Tuula A Salo; Clarissa Araujo Gurgel Rocha; Sabrina Daniela da Silva; Peter A Brennan; Ricardo D Coletta Journal: Front Oncol Date: 2021-11-10 Impact factor: 6.244
Authors: Alessia Di Rito; Francesco Fiorica; Roberta Carbonara; Francesca Di Pressa; Federica Bertolini; Francesco Mannavola; Frank Lohr; Angela Sardaro; Elisa D'Angelo Journal: Cancers (Basel) Date: 2022-07-29 Impact factor: 6.575
Authors: Marco Mascitti; Lucrezia Togni; Corrado Rubini; Giuseppe Troiano; Lorenzo Lo Muzio; Andrea Santarelli Journal: Histol Histopathol Date: 2020-09-28 Impact factor: 2.303